Results 51 to 60 of about 954,120 (303)

Computational analysis of noncoding RNAs [PDF]

, 2012
Noncoding RNAs have emerged as important key players in the cell. Understanding their surprisingly diverse range of functions is challenging for experimental and computational biology. Here, we review computational methods to analyze noncoding RNAs.
David A. Hendrix, Will, Sebastian, Washietl, Stefan, John L. Rinn, Hendrix, David A., Bonnie Berger, Loyal A. Goff, Stefan Washietl, Manolis Kellis, Sebastian Will, Kellis, Manolis, Goff, Loyal, Rinn, John L., Berger, Bonnie   +13 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The molecular dynamics of long noncoding RNA control of transcription in PTEN and its pseudogene

, 2017
Significance In recent years, noncoding RNA transcripts have been found to interact with genes and modulate their ability to be transcribed and made into protein.
Lister, Nicholas, Grander, Dan, Nicholas Lister, Ataide, Sandro F, Galina Shevchenko, Dan Grander, Per Johnsson, Groen, Jessica, Jessica Groen, Walshe, James L, Linda Vidarsdóttir, Shevchenko, Galina, Johnsson, Per, Morris, Kevin V, Kevin V. Morris, James L. Walshe, Sandro F. Ataide, Vidarsdottir, Linda, Lister, N, Walshe, JL, Johnsson, P,, Grander, D, Groen, J, Vidarsdottir, L, Morris, KV, Ataide, SF, Shevchenko, G   +26 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

m¹A and m⁶A RNA Methylations as Druggable Targets in Cancer

Pharmaceuticals
Epitranscriptomic modifications, particularly RNA methylations, have emerged as regulators of gene expression, with their dysregulation acting as a key factor in tumorigenesis and metastatic progression.
Yasemin Gazaloğlu, Buket Sağlam-Şen, Bünyamin Akgül   +2 more
doaj   +1 more source

Integrated Analysis of Gut Microbiome and Lipid Metabolism in Mice Infected with Carbapenem-Resistant Enterobacteriaceae

Metabolites, 2022
The disturbance in gut microbiota composition and metabolism has been implicated in the process of pathogenic bacteria infection. However, the characteristics of the microbiota and the metabolic interaction of commensals–host during pathogen invasion ...
Ning Zhang, Yuanyuan Peng, Linjing Zhao, Peng He, Jiamin Zhu, Yumin Liu, Xijian Liu, Xiaohui Liu, Guoying Deng, Zhong Zhang, Meiqing Feng   +10 more
doaj   +1 more source

Assessment of the Cardiac Noncoding Transcriptome by Single-Cell RNA Sequencing Identifies FIXER, a Conserved Profibrogenic Long Noncoding RNA. [PDF]

, 2023
BACKGROUND Cardiac fibroblasts have crucial roles in the heart. In particular, fibroblasts differentiate into myofibroblasts in the damaged myocardium, contributing to scar formation and interstitial fibrosis.
Bernasconi, R., Wigger, Leonore, Plaisance, Isabelle, Alexandre Sarre, Leonore Wigger, Pedrazzini, Thierry, Plaisance, I., Sarre, A., Wyss, Tania, Wyss, T., Panagiotis Chouvardas, Arantxa González, Pulido Quetglas, C., Aghagolzadeh, Parisa, Mohamed Nemir, Nemir, Mohamed, Bernasconi, Riccardo, Tania Wyss, Sarre, Alexandre, Wigger, L., Treibel, Thomas A, Riccardo Bernasconi, Pedrazzini, T., Thierry Pedrazzini, Nemir, M., González, Arantxa, Rory Johnson, Johnson, R., Pulido Quetglas, Carlos, Isabelle Plaisance, Chouvardas, P., Chouvardas, Panagiotis, Johnson, Rory, Thomas A. Treibel, Aghagolzadeh, P., Carlos Pulido Quetglas, Parisa Aghagolzadeh, González, A., Treibel, T.A.   +38 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Identification and Analysis of Human Sex-biased MicroRNAs

Genomics, Proteomics & Bioinformatics, 2018
Sex differences are widely observed under various circumstances ranging from physiological processes to therapeutic responses, and a myriad of sex-biased genes have been identified.
Chunmei Cui, Weili Yang, Jiangcheng Shi, Yong Zhou, Jichun Yang, Qinghua Cui, Yuan Zhou   +6 more
doaj   +1 more source