Results 51 to 60 of about 48,578 (287)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Interconnection structure preservation design for a type of port‐controlled hamiltonian systems—A parametric approach

IET Control Theory & Applications, 2021
It is a very important issue to minimise the change of the interconnect structure matrix when stabilising a port‐controlled Hamiltonian (PCH) system.
Tianyi Zhao, Guangren Duan
doaj   +1 more source

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

Boundary controllability of nonlinear stochastic fractional systems in Hilbert spaces

International Journal of Applied Mathematics and Computer Science, 2018
Sufficient conditions for the controllability of nonlinear stochastic fractional boundary control systems are established. The equivalent integral equations are derived for both linear and nonlinear systems, and the control function is given in terms of ...
Lizzy Rajendran Mabel, Balachandran Krishnan   +1 more
doaj   +1 more source

Study on stability and scalability of vehicular platoon with a bidirectional ring interconnection

IET Intelligent Transport Systems, 2021
This paper studies the stability and scalability of the platoon where multiple vehicles move in a closed roadway and are coupled in a bidirectional ring. Each vehicle regulates its longitudinal motion based on bidirectional asymmetric control with triple
Junying Zhang, Xindi Ma, Yong Wang
doaj   +1 more source

Diffusion Tractography Biomarker for Epilepsy Severity in Children With Drug‐Resistant Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To develop a novel deep‐learning model of clinical DWI tractography that can accurately predict the general assessment of epilepsy severity (GASE) in pediatric drug‐resistant epilepsy (DRE) and test if it can screen diverse neurocognitive impairments identified through neuropsychological assessments.
Jeong‐Won Jeong, Min‐Hee Lee, Hiroshi Uda, Yoon Ho Hwang, Michael Behen, Aimee Luat, Csaba Juhász, Eishi Asano   +7 more
wiley   +1 more source

Multi-Machine Power System Transient Stability Enhancement Utilizing a Fractional Order-Based Nonlinear Stabilizer

Fractal and Fractional, 2023
Given the intricate nature of contemporary energy systems, addressing the control and stability analysis of these systems necessitates the consideration of highly large-scale models. Transient stability analysis stands as a crucial challenge in enhancing
Arman Fathollahi, Björn Andresen
doaj   +1 more source

The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aim Multiple sclerosis is an autoimmune demyelination disease that is seen especially in the young population and has a progressive course, causing motor, sensory, and cognitive deficits. In the literature, the pathogenesis of MS disease and the interconnection between the immune and central nervous system in the disease have not been fully ...
Gamze Ansen, Ali Behram Salar, Abdulkadir Ermis, Erkingul Birday, Lutfu Hanoglu, Bayram Ufuk Sakul   +5 more
wiley   +1 more source

Finite‐time convergence for bilateral teleoperation systems with disturbance and time‐varying delays

IET Control Theory & Applications, 2021
This paper addresses the robust finite‐time sliding mode control algorithms for nonlinear bilateral teleoperators in the presence of variable time delays and disturbances.
Phuong Nam Dao, Van Tinh Nguyen, Yen‐Chen Liu   +2 more
doaj   +1 more source

Reduced Muscular Carnosine in Proximal Myotonic Myopathy—A Pilot 1H‐MRS Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Myotonic dystrophy type 2 (proximal myotonic myopathy, PROMM) is a progressive multisystem disorder with muscular symptoms (proximal weakness, pain, myotonia) and systemic manifestations such as diabetes mellitus, cataracts, and cardiac arrhythmias.
Alexander Gussew, Maryam Kargaran, Maik Rothe, Andreas Deistung, Dietrich Stoevesandt, Walter A. Wohlgemuth, David Strube, Thomas Kendzierski, Anna Katharina Kölsch, Maurits Gerhard Abraham Heuschen, Markus Otto, Alexander Mensch   +11 more
wiley   +1 more source