Results 51 to 60 of about 64,377 (317)

Optimal control strategies for a two-item production-maintenance system with deterioration

open access: yesResults in Control and Optimization
In this work, the problem of optimal control for a two-item production-maintenance system with deterioration is considered. An inventory system process performance can be evaluated by analyzing the proportion of good units produced as the end product ...
S. Sowmica, M. Suvinthra
doaj   +1 more source

Practical stability of time‐varying positive systems with time delay

open access: yesIET Control Theory & Applications, 2021
This paper considers the problem of practical stability for time‐varying positive systems with time delay. For both non‐linear time‐varying positive systems and linear time‐varying positive (LTVP) systems with time delay, sufficient conditions on ...
Ruonan Li, Ping Zhao
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Nonlinear control theory and chaotic dynamical systems [PDF]

open access: yesProceedings of the IEEE 1991 National Aerospace and Electronics Conference NAECON 1991, 2002
The author treats the role of multiparameters in the existence of solutions of highly coupled nonlinear dynamical systems and numerical computation of solutions. An attempt is made to develop methods applicable to control of highly coupled nonlinear dynamical systems containing multiparameters which may have a chaotic behavior.
openaire   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Adaptive backstepping complementary sliding mode control with parameter estimation and dead‐zone modification for PMLSM servo system

open access: yesIET Power Electronics, 2021
An adaptive backstepping complementary sliding mode control (ABCSMC) with dead‐zone parameter modification applicable to the permanent magnet linear synchronous motor is proposed in order to achieve high‐performance servo control fields.
Hongyan Jin, Ximei Zhao, Tianhe Wang
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Finite-Time Incremental Passivity and Output Tracking Control for Switched Nonlinear Systems

open access: yesIEEE Access, 2020
This paper studies the finite-time incremental passivity of switched nonlinear systems. Then, the established theory is applied to solve the finite-time output tracking control problem of switched nonlinear systems.
Shuo Liu, Hongbo Pang
doaj   +1 more source

Interconnection structure preservation design for a type of port‐controlled hamiltonian systems—A parametric approach

open access: yesIET Control Theory & Applications, 2021
It is a very important issue to minimise the change of the interconnect structure matrix when stabilising a port‐controlled Hamiltonian (PCH) system.
Tianyi Zhao, Guangren Duan
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

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