Results 111 to 120 of about 627,327 (211)

On the Evolution of Nonribosomal Peptide Synthetase Gene Clusters in Cyanobacteria [PDF]

, 2007
Cyanobacteria from genera Anabaena, Microcystis and Planktothrix produce a wide selection of nonribosomal peptides, e.g. microcystins and cyanopeptolins.
Tooming-Klunderud, Ave
core  

Mechanistic Insights Into the Biosynthesis of Pseurotin A in Aspergillus fumigatus

Small Structures
The biosynthesis of pseurotin A, a fungal metabolite with antibiotic and immunosuppressive properties, involves a group of enzymes, including a polyketide‐nonribosomal peptide synthase (PKS‐NRPS), PsoA, and a bifunctional enzyme, PsoF. PsoA consists of a
Lei Sun, Zi‐Long You, Rui‐Qing Lyu, Zhao‐Bin Wang, Ming Ma, Lin Bai   +5 more
doaj   +1 more source

Macrolactonization catalyzed by the terminal thioesterase domain of the nonribosomal peptide synthetase responsible for lichenysin biosynthesis

, 2005
The excised terminal thioesterase of the lichenysin nonribosomal peptide synthetase was found to be a highly efficient and versatile enzyme. Its activity strictly requires the R configuration of the β-hydroxy fatty acid and the side chains of aspartate-5
Yang, Yanzhen, Cao, Shuyong, Guo, Zhihong, Ng, Na Lee Joyce   +3 more
core   +1 more source

Suppression of linear side products by macromolecular crowding in nonribosomal enterobactin biosynthesis

, 2008
Nonribosomal enterobactin synthetase of Escherichia coli was found to prematurely release a large amount of linear precursors in an in vitro reconstitution.
Zheng, Suilan, Guo, Zhihong, Jiang, Ming, Guo, Zu Feng   +3 more
core   +1 more source

Cell-free protein synthesis for nonribosomal peptide synthetic biology

Frontiers in Natural Products
Peptide natural products have a wide range of useful applications as pesticides, veterinary agents, pharmaceuticals, and bioproducts. To discover new natural products, manipulate them for analog generation, and to harness the potential of these bioactive
Tien T. Sword, Ghaeath S. K. Abbas, Constance B. Bailey   +2 more
doaj   +1 more source

The Nonribosomal Peptide Synthetase Enzyme DdaD Tethers N_β-Fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-Ketoglutarate-Dependent Epoxidation by DdaC during Dapdiamide Antibiotic Biosynthesis

, 2016
The Nonribosomal Peptide Synthetase Enzyme DdaD Tethers Nβ-Fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-Ketoglutarate-Dependent Epoxidation by DdaC during Dapdiamide Antibiotic ...
J. Martin Bollinger (450755), Stefanie B. Bumpus (2135821), Megan L. Matthews (2232757), Neil L. Kelleher (548328), Christopher T. Walsh (1265718), Marie A. Hollenhorst (2199637)   +5 more
core   +1 more source

A portable pathway specific transcription factor-promoter circuit enables heterologous production of fungal nonribosomal peptides

Most fungal nonribosomal peptide synthetase (NRPS) biosynthetic gene clusters remain transcriptionally silent, severely restricting the discovery of bioactive peptide metabolites. Standard constitutive promoters fail to support robust expression of large.
Zedong Ren, Jie Fan, Peng-Lin Wei, Jinwei Ren, Wenbing Yin, Yuanyuan Li, Shengquan Zhang   +6 more
core   +1 more source

Suppression of Linear Side Products by Macromolecular Crowding in Nonribosomal Enterobactin Biosynthesis

, 2016
Nonribosomal enterobactin synthetase of Escherichia coli was found to prematurely release a large amount of linear precursors in an in vitro reconstitution.
Ming Jiang (11433), Zhihong Guo (404198), Zu-Feng Guo (2185165), Suilan Zheng (2389246)   +3 more
core   +1 more source

Recent advances in engineering nonribosomal peptide assembly lines.

, 2016
Covering: up to July 2015Nonribosomal peptides are amongst the most widespread and structurally diverse secondary metabolites in nature with many possessing bioactivity that can be exploited for therapeutic applications.
Winn, Michael, Micklefield, J, Fyans, Joanna, Zhuo, Ying   +3 more
core   +1 more source

Biosynthesis of the putative siderophore erythrochelin requires unprecedented crosstalk between separate nonribosomal peptide gene clusters

, 2010
The genome of the erythromycin-producing bacterium Saccharopolyspora erythraea contains many orphan secondary metabolite gene clusters including two (nrps3 and nrps5) predicted to govern biosynthesis of nonribosomal peptide-based siderophores.
Lazos, Orestis, Sidebottom, Philip J., Slusarczyk, Adrian L., Cortés, Jesus, Tosin, Manuela, Leadlay, P. F., Boakes, Steven   +6 more
core   +1 more source