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The Nonsense-Mediated Decay RNA Surveillance Pathway
Annual Review of Biochemistry, 2007Nonsense-mediated mRNA decay (NMD) is a quality-control mechanism that selectively degrades mRNAs harboring premature termination (nonsense) codons. If translated, these mRNAs can produce truncated proteins with dominant-negative or deleterious gain-of-function activities. In this review, we describe the molecular mechanism of NMD.
Yao-Fu, Chang +2 more
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Nonsense-mediated mRNA decay: terminating erroneous gene expression
Current Opinion in Cell Biology, 2004Nonsense-mediated mRNA decay is a surveillance pathway that reduces errors in gene expression by eliminating aberrant mRNAs that encode incomplete polypeptides. Recent experiments suggest a working model whereby premature and normal translation termination events are distinct as a consequence of the spatial relationship between the termination codon ...
Kristian E, Baker, Roy, Parker
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Biochemical Society Transactions, 2008
Translation and mRNA decay are coupled processes; the link is most obvious in the case of NMD (nonsense-mediated mRNA decay). NMD is a mechanism that drastically reduces the level of mRNA harbouring PTCs (premature translation termination codons). The defining event in NMD is premature translation termination and the key question is: what distinguishes
Jikai, Wen, Saverio, Brogna
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Translation and mRNA decay are coupled processes; the link is most obvious in the case of NMD (nonsense-mediated mRNA decay). NMD is a mechanism that drastically reduces the level of mRNA harbouring PTCs (premature translation termination codons). The defining event in NMD is premature translation termination and the key question is: what distinguishes
Jikai, Wen, Saverio, Brogna
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Nonsense-mediated mRNA decay (NMD) mechanisms
Nature Structural & Molecular Biology, 2009Nonsense-mediated mRNA decay (NMD) is a translation-coupled mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In mammalian cells, NMD is also linked to pre-mRNA splicing, as in many instances strong mRNA reduction occurs only when the PTC is located upstream of an intron.
Saverio, Brogna, Jikai, Wen
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Nonsense-mediated decay approaches the clinic
Nature Genetics, 2004Nonsense-mediated decay (NMD) eliminates mRNAs containing premature termination codons and thus helps limit the synthesis of abnormal proteins. New results uncover a broader role of NMD as a pathway that also affects the expression of wild-type genes and alternative-splice products.
Jill A, Holbrook +3 more
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Regulation of nonsense‐mediated mRNA decay
WIREs RNA, 2012AbstractNonsense‐mediated mRNA decay (NMD) is a highly conserved pathway that was originally identified as a RNA surveillance mechanism that degrades aberrant mRNAs harboring premature termination (nonsense) codons. Recently, it was discovered that NMD also regulates normal gene expression.
Lulu, Huang, Miles F, Wilkinson
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Nonsense mediated RNA decay and evolutionary capacitance
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2016Nonsense mediated RNA decay (NMD) is well-known as an RNA quality control mechanism that sequesters a substantial portion of RNA from expression by targeting it for degradation. However, a number of recent studies across a range of organisms indicate a broader role for NMD in gene regulation and transcriptome homeostasis.
Vivek Kumar, Raxwal, Karel, Riha
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Nonsense-mediated mRNA Decay in Yeast
1994Publisher Summary This chapter describes the mRNA-destabilizing phenomenon as nonsense-mediated mRNA decay, and reviews the cis-acting sequences and trans-acting factors that comprise this pathway in the yeast Saccharomyces cerevisiae. The observation that premature translation termination can promote rapid mRNA decay is just one in a large set of ...
Peltz, Stuart W. +3 more
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Aberrant termination triggers nonsense-mediated mRNA decay
Biochemical Society Transactions, 2006NMD (nonsense-mediated mRNA decay) is a cellular quality-control mechanism in which an otherwise stable mRNA is destabilized by the presence of a premature termination codon. We have defined the set of endogenous NMD substrates, demonstrated that they are available for NMD at every round of translation, and showed that premature termination and normal ...
Amrani, Nadia +9 more
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Nonsense-mediated mRNA decay in Saccharomyces cerevisiae
Gene, 2001Cell survival depends on the precise and correct production of polypeptides. Eukaryotic cells have evolved conserved proofreading mechanisms to get rid of incomplete and potentially deleterious proteins. The nonsense-mediated mRNA decay (NMD) pathway is an example of a surveillance mechanism that monitors premature translation termination and promotes ...
C I, González +3 more
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