Results 221 to 230 of about 59,267 (253)
Some of the next articles are maybe not open access.
Nonsense-Mediated mRNA Decay and Cystic Fibrosis
2011Approximately one-third of the alleles causing genetic diseases carry premature termination codons (PTCs). Therapeutic approaches for mutations generating in-frame PTCs are aimed at promoting translational readthrough of the PTC, to enable the synthesis and expression of full-length functional proteins.
Liat, Linde, Batsheva, Kerem
openaire +2 more sources
Incomplete nonsense-mediated mRNA decay in Giardia lamblia
International Journal for Parasitology, 2008Messenger RNAs containing premature translation stop codons are degraded by a nonsense-mediated mRNA decay (NMD) system. The NMD pathway is present in yeast, plants and mammals and is thought to protect cells from production of nonfunctional proteins by rapidly degrading mutant mRNAs.
Yi-Hsiu, Chen +2 more
openaire +2 more sources
An UPF3-based nonsense-mediated decay in Paramecium
Research in Microbiology, 2014Nonsense-mediated decay recognises mRNAs containing premature termination codons. One of its components, UPF3, is a molecular link bridging through its binding to the exon junction complex nonsense-mediated decay and splicing. In protists UPF3 has not been identified yet.
Julia Contreras +3 more
openaire +2 more sources
Nonsense‐mediated decay of human LDL receptor mRNA
Scandinavian Journal of Clinical and Laboratory Investigation, 2009The objective of this project was to determine whether nonsense mutation in the low density lipoprotein receptor (LDLR) induces nonsense-mediated mRNA decay (NMD).Four known nonsense mutations (W23X, S78X, E207X and W541X) in the LDLR gene, which are found in Norwegian familial hypercholesterolaemia (FH) patients, were investigated. Epstein-Barr virus (
Øystein Lunde, Holla +4 more
openaire +2 more sources
How Retroviruses Escape the Nonsense-Mediated mRNA Decay
AIDS Research and Human Retroviruses, 2015Many posttranscriptional processes are known to regulate gene expression and some of them can act as an antiviral barrier. The nonsense-mediated mRNA decay (NMD) was first identified as an mRNA quality control pathway that triggers rapid decay of mRNA containing premature stop codons due to mutations.
Vincent, Mocquet +2 more
openaire +2 more sources
Autism and Nonsense Mediated Decay (NMD)
Journal of Neurology and Neuroscience, 2015Autism is a complex childhood developmental disability that causes problems with social interaction and communication [1]. “Infantile Autism” was first diagnosed and classified by Kanner [2] and for nearly 50 years was viewed as relatively rare, low incidence condition.
openaire +1 more source
CYP3A5 mRNA Degradation by Nonsense-Mediated mRNA Decay
Molecular Pharmacology, 2005The total CYP3A5 mRNA level is significantly greater in carriers of the CYP3A5*1 allele than in CYP3A5*3 homozygotes. Most of the CYP3A5*3 mRNA includes an intronic sequence (exon 3B) containing premature termination codons (PTCs) between exons 3 and 4.
Florent, Busi, Thierry, Cresteil
openaire +2 more sources
Nonsense-mediated RNA decay: an emerging modulator of malignancy
Nature Reviews Cancer, 2022Kun Tan, Miles F Wilkinson
exaly
Quality and quantity control of gene expression by nonsense-mediated mRNA decay
Nature Reviews Molecular Cell Biology, 2019Tatsuaki Kurosaki +2 more
exaly
Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes
Nature Reviews Molecular Cell Biology, 2015Søren Lykke-Andersen +1 more
exaly