Results 221 to 230 of about 50,057 (258)

A faux 3′-UTR promotes aberrant termination and triggers nonsense- mediated mRNA decay

Nature, 2004
N. Amrani, R. Ganesan, S. Kervestin, D. A. Mangus, S. Ghosh, A. Jacobson   +5 more
semanticscholar   +3 more sources

Nonsense-mediated mRNA decay

Biochemical Society Transactions, 2008
Translation and mRNA decay are coupled processes; the link is most obvious in the case of NMD (nonsense-mediated mRNA decay). NMD is a mechanism that drastically reduces the level of mRNA harbouring PTCs (premature translation termination codons). The defining event in NMD is premature translation termination and the key question is: what distinguishes
Jikai, Wen, Saverio, Brogna
openaire   +2 more sources

Regulation of nonsense‐mediated mRNA decay

WIREs RNA, 2012
AbstractNonsense‐mediated mRNA decay (NMD) is a highly conserved pathway that was originally identified as a RNA surveillance mechanism that degrades aberrant mRNAs harboring premature termination (nonsense) codons. Recently, it was discovered that NMD also regulates normal gene expression.
Lulu, Huang, Miles F, Wilkinson
openaire   +2 more sources

CYP3A5 mRNA Degradation by Nonsense-Mediated mRNA Decay

Molecular Pharmacology, 2005
The total CYP3A5 mRNA level is significantly greater in carriers of the CYP3A5*1 allele than in CYP3A5*3 homozygotes. Most of the CYP3A5*3 mRNA includes an intronic sequence (exon 3B) containing premature termination codons (PTCs) between exons 3 and 4.
Florent, Busi, Thierry, Cresteil
openaire   +2 more sources

Aberrant termination triggers nonsense-mediated mRNA decay

Biochemical Society Transactions, 2006
NMD (nonsense-mediated mRNA decay) is a cellular quality-control mechanism in which an otherwise stable mRNA is destabilized by the presence of a premature termination codon. We have defined the set of endogenous NMD substrates, demonstrated that they are available for NMD at every round of translation, and showed that premature termination and normal ...
Amrani, Nadia, Dong, Shuyun, He, Feng, Ganesan, Robin, Ghosh, Shubhendu, Kervestin, Stephanie, Li, Chunfang, Mangus, David A., Spatrick, Phyllis, Jacobson, Allan   +9 more
openaire   +3 more sources

Nonsense-Mediated mRNA Decay: Mechanistic Insights and Physiological Significance

Molecular Biotechnology, 2023
Nonsense-mediated mRNA decay (NMD) is an evolutionarily conserved surveillance mechanism across eukaryotes and also regulates the expression of physiological transcripts, thus involved in gene regulation. It essentially ensures recognition and removal of aberrant transcripts.
I. Patro, Annapurna Sahoo, Bilash Ranjan Nayak, Rutupurna Das, Sanjoy Majumder, G. K. Panigrahi   +5 more
semanticscholar   +3 more sources

Nonsense-mediated mRNA Decay in Yeast

1994
Publisher Summary This chapter describes the mRNA-destabilizing phenomenon as nonsense-mediated mRNA decay, and reviews the cis-acting sequences and trans-acting factors that comprise this pathway in the yeast Saccharomyces cerevisiae. The observation that premature translation termination can promote rapid mRNA decay is just one in a large set of ...
Peltz, Stuart W., He, Feng, Welch, Ellen Marie, Jacobson, Allan   +3 more
openaire   +3 more sources

Nonsense-mediated mRNA decay in Saccharomyces cerevisiae

Gene, 2001
Cell survival depends on the precise and correct production of polypeptides. Eukaryotic cells have evolved conserved proofreading mechanisms to get rid of incomplete and potentially deleterious proteins. The nonsense-mediated mRNA decay (NMD) pathway is an example of a surveillance mechanism that monitors premature translation termination and promotes ...
C I, González, A, Bhattacharya, W, Wang, S W, Peltz   +3 more
openaire   +2 more sources

Incomplete nonsense-mediated mRNA decay in Giardia lamblia

International Journal for Parasitology, 2008
Messenger RNAs containing premature translation stop codons are degraded by a nonsense-mediated mRNA decay (NMD) system. The NMD pathway is present in yeast, plants and mammals and is thought to protect cells from production of nonfunctional proteins by rapidly degrading mutant mRNAs.
Yi-Hsiu, Chen, Li-Hsin, Su, Chin-Hung, Sun   +2 more
openaire   +2 more sources

Nonsense-Mediated mRNA Decay and Cystic Fibrosis

2011
Approximately one-third of the alleles causing genetic diseases carry premature termination codons (PTCs). Therapeutic approaches for mutations generating in-frame PTCs are aimed at promoting translational readthrough of the PTC, to enable the synthesis and expression of full-length functional proteins.
Liat, Linde, Batsheva, Kerem
openaire   +2 more sources