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Nonsense‐mediated decay of human LDL receptor mRNA
Scandinavian Journal of Clinical and Laboratory Investigation, 2009The objective of this project was to determine whether nonsense mutation in the low density lipoprotein receptor (LDLR) induces nonsense-mediated mRNA decay (NMD).Four known nonsense mutations (W23X, S78X, E207X and W541X) in the LDLR gene, which are found in Norwegian familial hypercholesterolaemia (FH) patients, were investigated. Epstein-Barr virus (
Øystein Lunde, Holla +4 more
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How Retroviruses Escape the Nonsense-Mediated mRNA Decay
AIDS Research and Human Retroviruses, 2015Many posttranscriptional processes are known to regulate gene expression and some of them can act as an antiviral barrier. The nonsense-mediated mRNA decay (NMD) was first identified as an mRNA quality control pathway that triggers rapid decay of mRNA containing premature stop codons due to mutations.
Vincent, Mocquet +2 more
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Unique Aspects of Plant Nonsense-Mediated mRNA Decay
Trends in Plant Science, 2015Nonsense-mediated mRNA Decay (NMD) is a eukaryotic quality-control mechanism that governs the stability of both aberrant and normal transcripts. Although plant and mammalian NMD share great similarity, they differ in certain mechanistic and regulatory aspects. Whereas SMG6 (from Caenorhabditis elegans 'suppressor with morphogenetic effect on genitalia')
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A new function for nonsense-mediated mRNA-decay factors
Trends in Genetics, 2005mRNAs often contain premature-termination (nonsense) codons as a result of mutations and RNA splicing errors. These nonsense codons cause rapid decay of the mRNAs that contain them, a phenomenon called nonsense-mediated mRNA decay (NMD). This response is thought to be a quality-control mechanism that protects cells from truncated dominant-negative ...
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Nonsense-mediated mRNA decay: molecular insights and mechanistic variations across species.
Current Opinion in Cell Biology, 2005E. Conti, E. Izaurralde
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Nonsense-mediated RNA decay: an emerging modulator of malignancy
Nature Reviews Cancer, 2022Kun Tan, Miles F Wilkinson
exaly
The Branched Nature of the Nonsense-Mediated mRNA Decay Pathway
Trends in Genetics, 2021Zhongxia Yi, Guramrit Singh
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Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells.
Current Opinion in Cell Biology, 2005F. Lejeune, L. Maquat
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Alternative splicing resulting in nonsense-mediated mRNA decay: what is the meaning of nonsense?
TIBS -Trends in Biochemical Sciences. Regular ed, 2008Nicholas J. McGlincy +1 more
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