Results 161 to 170 of about 13,111 (197)

Mechanism of zinc ejection by disulfiram in nonstructural protein 5A

Physical Chemistry Chemical Physics, 2021
Hepatitis C virus (HCV) is a notorious member of the Flaviviridae family of enveloped, positive-strand RNA viruses.
Ashfaq Ur Rehman, Guodong Zhen, Bozitao Zhong, Duan Ni, Jiayi Li, Abdul Nasir, Moustafa T. Gabr, Humaira Rafiq, Abdul Wadood, Shaoyong Lu, Jian Zhang, Hai-Feng Chen   +11 more
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Analysis for codon usage bias in membrane anchor of nonstructural protein 5A from BVDV

Journal of Basic Microbiology, 2023
AbstractThe nonstructural protein 5A (NS5A) of the bovine viral diarrhea virus (BVDV) is a monotopic membrane protein. This protein can anchor to the cell membrane by an in‐plane amphipathic ⍺‐helix, which participates in the viral replication complex.
Mingyang Gao, Xuanye Yang, Yuhu Wu, Jinqian Wang, Xinyan Hu, Zhongren Ma, Jian‐hua Zhou   +6 more
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Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator

Journal of Virology, 1997
The hepatitis C virus (HCV) nonstructural region 5A (NS5A) protein, without its 146 amino-terminal amino acids and fused to the DNA-binding domain of GAL4, strongly activates transcription in yeast and human hepatoma cells. Transcriptional activation by the HCV NS5A protein may play a role in viral replication and hepatocarcinogenesis.
N, Kato, K H, Lan, S K, Ono-Nita, Y, Shiratori, M, Omata   +4 more
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Characterization of monoclonal antibodies against the nonstructural 5A protein of hepatitis C virus

Archives of Virology, 2009
The nonstructural 5A (NS5A) protein of hepatitis C virus (HCV) is a multifunctional protein that leads to pleiotropic responses, in part by regulating cell growth and cellular signaling pathways. Here, we produced monoclonal antibodies (mAbs) directed against the HCV NS5A protein.
Sang Min, Kang, Hyun-Jung, Jun, Yun-Sook, Lim, Soo-Ho, Choi, Soon B, Hwang   +4 more
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Positive effect of the hepatitis C virus nonstructural 5A protein on viral multiplication

Archives of Virology, 2004
Hepatitis C virus infection (HCV), is a major cause of liver disease worldwide, and are frequently resistant to the interferon alpha treatment. The nonstructural (NS) 5A protein of HCV has been proposed to be involved in this resistance. Additional studies have pointed out a role for NS5A in several other cellular interactions as well as an important ...
D, Bonte, C, François, S, Castelain, C, Wychowski, J, Dubuisson, E F, Meurs, G, Duverlie   +6 more
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SUMOylation of nonstructural 5A protein regulates hepatitis C virus replication

Journal of Viral Hepatitis, 2014
SummaryViruses exploit cellular SUMOylation machinery to favour their own propagation. We show that NS5A is a target protein of small ubiquitin‐like modifier (SUMO) and is SUMOylated at lysine residue 348. We demonstrated that SUMOylation increased protein stability of NS5A by inhibiting ubiquitylation, and SUMOylation was also required for protein ...
H S, Lee, Y S, Lim, E M, Park, S H, Baek, S B, Hwang   +4 more
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Characterization and application of monoclonal antibodies to bovine viral diarrhea virus nonstructural protein 5A

Archives of Virology, 2009
Bovine viral diarrhea virus (BVDV) nonstructural protein 5A (NS5A) is one the least studied of the BVDV proteins. Therefore, to develop a tool for unraveling the functions performed by BVDV NS5A, monoclonal antibodies (MAbs) were generated by fusion of myeloma cells with spleen cells from mice immunized with recombinant E.
Muhammad Atif, Zahoor, Daisuke, Yamane, Yassir Mahgoub, Mohamed, Kyousuke, Kobayashi, Kentaro, Kato, Yukinobu, Tohya, Hiroomi, Akashi   +6 more
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Viperin inhibits classical swine fever virus replication by interacting with viral nonstructural 5A protein

Journal of Medical Virology, 2019
AbstractClassical swine fever virus (CSFV) is a single‐stranded RNA flavivirus that can cause serious diseases in porcine species, including symptoms of infarction, systemic hemorrhage, high fever, or depression. Viperin is an important interferon‐inducible antiviral gene that has been shown to inhibit CSFV, but the exact mechanisms by which it is able
Chunmei Xu, Luping Feng, Peige Chen, Anqi Li, Shuang Guo, Xianqin Jiao, Chengyu Zhang, Yunze Zhao, Xiangyang Jin, Kai Zhong, Yujie Guo, Heshui Zhu, Liqiang Han, Guoyu Yang, Heping Li, Yueying Wang   +15 more
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Differential Effect of Interferon on Hepatitis C Virus 1b Quasispecies in the Nonstructural Protein 5A Gene

The Journal of Infectious Diseases, 1999
A close correlation was reported between amino acid mutations in the nonstructural protein 5A (interferon [IFN] sensitivity-determining region [ISDR]) of hepatitis C virus (HCV)-1b and the response to IFN therapy. The dynamic change of ISDR quasispecies during IFN treatment was investigated in 22 patients.
I, Sakuma, N, Enomoto, M, Kurosaki, N, Izumi, F, Marumo, C, Sato   +5 more
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Identification of cellular targets of Hepatitis C Virus Nonstructural Protein 5A.

2005
Hepatitis C virus (HCV) is a small RNA virus that causes severe liver pathogenesis in humans. It encodes for 3 structural and at least 7 non- structural proteins. The non-structural protein 5A (NS5A) has been implicated in the deregulation of host cell signal transduction, interfering with signaling pathways that regulate cell growth, cell ...
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