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Nonstructural 5A protein of hepatitis C virus regulates heat shock protein 72 for its own propagation

Journal of Viral Hepatitis, 2011
Summary.  We identified heat shock protein 72 (Hsp72) as a host factor that was differentially expressed in cells expressing nonstructural 5A (NS5A) protein. To investigate how NS5A modulates Hsp72 in hepatitis C virus (HCV) life cycle, we examined the role of Hsp72 in HCV replication and virus production. NS5A specifically interacted with Hsp72.
Y S, Lim   +5 more
openaire   +2 more sources

HCV Inhibition Mediated Through the Nonstructural Protein 5A (NS5A) Replication Complex

2012
Abstract Chronic infection by hepatitis C virus (HCV) results in increased risk for cirrhosis and hepatocellular carcinoma. Current treatments of HCV infection use inhibitors of HCV NS3 protease in combination with pegylated interferon α and ribavirin resulting in approximately 70% cure rates.
Robert Hamatake   +2 more
openaire   +1 more source

Structural insights into viral RNA capping and plasma membrane targeting by Chikungunya virus nonstructural protein 1

Cell Host and Microbe, 2021
Yee-Song Law   +2 more
exaly  

Structural basis for IFN antagonism by human respiratory syncytial virus nonstructural protein 2

Proceedings of the National Academy of Sciences of the United States of America, 2021
Jingjing Pei   +2 more
exaly  

Interactions with phospholipids and membrane remodeling by nonstructural protein 5A of hepatitis C virus

Zeitschrift für Gastroenterologie, 2021
AV Bulankina   +10 more
openaire   +1 more source

Anti-dengue virus nonstructural protein 1 antibodies contribute to platelet phagocytosis by macrophages

Thrombosis and Haemostasis, 2016
Chiou-Feng Lin   +2 more
exaly  

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