Results 171 to 180 of about 18,126 (202)

Positive effect of the hepatitis C virus nonstructural 5A protein on viral multiplication

Archives of Virology, 2004
Hepatitis C virus infection (HCV), is a major cause of liver disease worldwide, and are frequently resistant to the interferon alpha treatment. The nonstructural (NS) 5A protein of HCV has been proposed to be involved in this resistance. Additional studies have pointed out a role for NS5A in several other cellular interactions as well as an important ...
D, Bonte, C, François, S, Castelain, C, Wychowski, J, Dubuisson, E F, Meurs, G, Duverlie   +6 more
openaire   +2 more sources

Characterization of monoclonal antibodies against the nonstructural 5A protein of hepatitis C virus

Archives of Virology, 2009
The nonstructural 5A (NS5A) protein of hepatitis C virus (HCV) is a multifunctional protein that leads to pleiotropic responses, in part by regulating cell growth and cellular signaling pathways. Here, we produced monoclonal antibodies (mAbs) directed against the HCV NS5A protein.
Sang Min, Kang, Hyun-Jung, Jun, Yun-Sook, Lim, Soo-Ho, Choi, Soon B, Hwang   +4 more
openaire   +2 more sources

Viperin inhibits classical swine fever virus replication by interacting with viral nonstructural 5A protein

Journal of Medical Virology, 2019
AbstractClassical swine fever virus (CSFV) is a single‐stranded RNA flavivirus that can cause serious diseases in porcine species, including symptoms of infarction, systemic hemorrhage, high fever, or depression. Viperin is an important interferon‐inducible antiviral gene that has been shown to inhibit CSFV, but the exact mechanisms by which it is able
Chunmei Xu, Luping Feng, Peige Chen, Anqi Li, Shuang Guo, Xianqin Jiao, Chengyu Zhang, Yunze Zhao, Xiangyang Jin, Kai Zhong, Yujie Guo, Heshui Zhu, Liqiang Han, Guoyu Yang, Heping Li, Yueying Wang   +15 more
openaire   +2 more sources

HCV Inhibition Mediated Through the Nonstructural Protein 5A (NS5A) Replication Complex

2012
Abstract Chronic infection by hepatitis C virus (HCV) results in increased risk for cirrhosis and hepatocellular carcinoma. Current treatments of HCV infection use inhibitors of HCV NS3 protease in combination with pegylated interferon α and ribavirin resulting in approximately 70% cure rates.
Robert Hamatake, Andrew Maynard, Wieslaw M. Kazmierski   +2 more
openaire   +1 more source

Characterization and application of monoclonal antibodies to bovine viral diarrhea virus nonstructural protein 5A

Archives of Virology, 2009
Bovine viral diarrhea virus (BVDV) nonstructural protein 5A (NS5A) is one the least studied of the BVDV proteins. Therefore, to develop a tool for unraveling the functions performed by BVDV NS5A, monoclonal antibodies (MAbs) were generated by fusion of myeloma cells with spleen cells from mice immunized with recombinant E.
Muhammad Atif, Zahoor, Daisuke, Yamane, Yassir Mahgoub, Mohamed, Kyousuke, Kobayashi, Kentaro, Kato, Yukinobu, Tohya, Hiroomi, Akashi   +6 more
openaire   +2 more sources

The successful immune response against hepatitis C nonstructural protein 5A (NS5A) requires heterologous DNA/protein immunization

Vaccine, 2010
The aim of this study was to evaluate the immunogenicity of NS5A protein of human hepatitis C virus (HCV) when delivered as naked DNA (NS5A DNA), or recombinant protein (rNS5A). DBA/2J mice received NS5A DNA, rNS5A, or NS5A DNA/rNS5A in different prime-boost combinations with a peptidoglycan Immunomax((R)).
Olga V, Masalova, Ekaterina I, Lesnova, Alexei V, Pichugin, Tatiana M, Melnikova, Vadim V, Grabovetsky, Natalia V, Petrakova, Olga A, Smirnova, Alexander V, Ivanov, Alexei D, Zaberezhny, Ravshan I, Ataullakhanov, Maria G, Isaguliants, Alla A, Kushch   +11 more
openaire   +2 more sources

Nonstructural 5A protein of hepatitis C virus regulates heat shock protein 72 for its own propagation

Journal of Viral Hepatitis, 2011
Summary.  We identified heat shock protein 72 (Hsp72) as a host factor that was differentially expressed in cells expressing nonstructural 5A (NS5A) protein. To investigate how NS5A modulates Hsp72 in hepatitis C virus (HCV) life cycle, we examined the role of Hsp72 in HCV replication and virus production. NS5A specifically interacted with Hsp72.
Y S, Lim, K S, Shin, S H, Oh, S M, Kang, S J, Won, S B, Hwang   +5 more
openaire   +2 more sources

Hepatitis C virus nonstructural protein-5A activates sterol regulatory element-binding protein-1c through transcription factor Sp1

Biochemical and Biophysical Research Communications, 2010
Steatosis is an important clinical manifestation of hepatitis C virus (HCV) infection. The molecular mechanisms of HCV-associated steatosis are not well understood. Sterol regulatory element-binding protein-1c (SREBP-1c) is a key transcription factor which activates the transcription of lipogenic genes.
Zhonghua, Xiang, Ling, Qiao, Yan, Zhou, Lorne A, Babiuk, Qiang, Liu   +4 more
openaire   +2 more sources

Structural insights into viral RNA capping and plasma membrane targeting by Chikungunya virus nonstructural protein 1

Cell Host and Microbe, 2021
zhang kuo, Yee-Song Law, Michelle Law
exaly  

Structural basis for IFN antagonism by human respiratory syncytial virus nonstructural protein 2

Proceedings of the National Academy of Sciences of the United States of America, 2021
Jingjing Pei, Nicole D Wagner, Srirupa Chatterjee   +2 more
exaly