Results 111 to 120 of about 1,587,098 (210)

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, Volume 13, Issue 54, 28 September 2026.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Identification and characterization of a novel non-structural protein of bluetongue virus [PDF]

, 2011
Bluetongue virus (BTV) is the causative agent of a major disease of livestock (bluetongue). For over two decades, it has been widely accepted that the 10 segments of the dsRNA genome of BTV encode for 7 structural and 3 non-structural proteins.
Rixon, F., Palmarini, M., Ratinier Maxime, Ratinier, Maxime, Golder, Matthew, Nunes, S.F., Alessia Armezzani, Sandro Filipe Nunes, Kathryn Allan, Allan Kathryn, Allan, K., Rixon, Frazer, Golder, M., Allan, Kathryn, Nunes Sandro Filipe, Frazer Rixon, Bayoumy, Amr, Shaw, A., Matthew Golder, Franzoni, G., Caporale Marco, Giulia Franzoni, Golder Matthew, Nunes, Sandro Filipe, Bayoumy Amr, Shaw, Andrew, Amr Bayoumy, Palmarini Massimo, Armezzani, A., Shaw Andrew, Palmarini, Massimo, Ratinier, M., Armezzani, Alessia, Franzoni Giulia, Franzoni, Giulia, Maxime Ratinier, Andrew Shaw, Rixon Frazer, Marco Caporale, Massimo Palmarini, Armezzani Alessia, Bayoumy, A., Caporale, Marco, Caporale, M.   +43 more
core   +1 more source

Magnetic Bead‐Based Ligand Fishing Identifies SARS‐CoV‐2 Main Protease Inhibitors From Reynoutria japonica

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
A magnetic bead‐based ligand fishing workflow using immobilized SARS‐CoV‐2 Mpro was coupled with UPLC‐Q‐Exactive‐Orbitrap‐MS/MS to screen potential Mpro‐binding constituents directly from a crude Reynoutria japonica extract. Eight compounds were captured and annotated, of which six showed concentration‐dependent Mpro inhibition, with resveratrol ...
Yujing Huang, Chenjing Tian, Zhipeng Gu, Jinlian Liang, Duntao Zu, Jianni Yang, Wanrong Zhang, Nina Ren, Junxia Zheng   +8 more
wiley   +1 more source

Functional studies on the rotavirus non-structural proteins NSP5 and NSP6 [PDF]

The rotavirus replication cycle has not been fully characterised, one vital stage of virus replication involves large cytoplasmic occlusion bodies termed viroplasms.
Rainsford, Edward
core  

The Significance of cGAS‐STING Signaling in Response to Oncogenic Viruses

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT The cyclic GMP‐AMP synthase (cGAS)‐stimulator of interferon genes (STING) signaling pathway, as a key DNA sensor, plays a significant role in the regulation of innate immune responses. This pathway can be activated by sensing abnormal DNA, and is of great significance for resisting the invasion of pathogenic microorganisms and maintaining ...
Limei Guo, Li Li, Fang Wang, Wen Liu, Yan Zhang   +4 more
wiley   +1 more source

Subcellular location and protein interactions of the infectious bronchitis virus gene 3 and 5 accessory proteins [PDF]

The avian coronavirus infectious bronchitis virus (IBV) expresses four nonstructural, non-gene 1 proteins (3a, 3b, 5a and 5b) which have been shown to be dispensable for virus replication in cell culture.
Davies, Marc Tudor
core  

Functional Analysis of Viral Nonstructural and Structural Proteins [PDF]

, 1989
The genera Alphavirus and Flavivirus contain enveloped RNA viruses which are similar in size, morphology, and RNA content, and were once considered to belong to the same family, the Togaviridae.
Hahn, Young Shin Lim
core   +1 more source

Culture‐Negative Septic Pulmonary Embolism Secondary to Lower‐Limb Cellulitis Following Recent Dengue Fever Complicated by Hydropneumothorax: A Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Secondary bacterial infection and septic pulmonary embolism should be considered in patients recovering from dengue fever who develop focal soft‐tissue infection, respiratory symptoms, or markedly elevated inflammatory markers. Characteristic radiological findings may establish the diagnosis even when blood cultures are negative and infective ...
Faiza Arif, Mariyah Saqib Qureshi, Sajjad Khan, Malaika Usman, Umama Rehman, Aiyna Usman, Bilal Wazir Khan, Kashif Yousaf   +7 more
wiley   +1 more source

Molecular basis for cytolytic T-lymphocyte recognition of the murine cytomegalovirus immediate-early protein pp89 [PDF]

, 1988
The murine cytomegalovirus protein pp89, which is encoded by gene ieI, is a nonstructural regulatory protein expressed in the immediate-early phase of the viral replication cycle and located mainly in the nucleus of infected cells.
Reddehase, Matthias J., Del Val, Margarita, Koszinowski, Ulrich H., Schickedanz, Jörg, Volkmer, Hansjürgen, Messerle, Martin, Jonjic, Stipan, Rothbard, Jonathan B.   +7 more
core   +1 more source

Molecularly imprinted polymers based electrochemical sensors for biomarker detection in biofluids

InfoScience, Volume 3, Issue 3, September 2026.
This review systematically summarizes the evolution of molecularly imprinted polymer electrochemical sensors from bulk structures to advanced nano‐imprinted architectures. It decouples the complex matrix effects of clinical biofluids and evaluates interfacial engineering strategies for anti‐biofouling.
Tianrui Zhu, Guobao Yao, Haoming Jiang, Yuan Gao, Yinchao Zhao, Hao Shen, Dequn Wu, Qifeng Lu   +7 more
wiley   +1 more source