Results 121 to 130 of about 1,587,098 (210)

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 9, September 2026.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Dengue Virus Molecular Targets and Antiviral Drug Development: Advances, Challenges and Therapeutic Perspectives

ChemistrySelect, Volume 11, Issue 33, 1 September 2026.
This narrative review analyzes DENV molecular targets, including structural proteins (C, prM/M, E), non‐structural components (NS1NS5), and host factors, alongside small‐molecule candidates in preclinical and clinical phases. Owing to high structural conservation, the NS2B‐NS3 protease and NS5 (RdRp/MTase) remain primary drug discovery focuses, while ...
Aryane Lucia da Silva Aguiar De Oliveira, José Arion Da Silva Moura, Pedro César de Souza, Marcelo Arthur Dias da Costa Santana, Matheus Vinicius Guimarães de Melo, Douglas Carvalho Francisco Viana, Marina Galdino Da Rocha Pitta, Isabella Luiza Ralph de Oliveira, Maira Galdino Da Rocha Pitta   +8 more
wiley   +1 more source

The characterization and processing of the nonstructural proteins of Sindbis virus [PDF]

, 1990
NOTE: Text or symbols not renderable in plain ASCII are indicated by [...]. Abstract is included in .pdf document. SHORT ABSTRACT: The nonstructural proteins of Sindbis virus, the type alphavirus of the family Togaviridae, are produced by proteolytic ...
Hardy, Winters Reef
core   +1 more source

Alphavirus replicase and regulatory RNA elements in host interactions and viral vector engineering

Journal of Virology
Alphavirus-derived vector systems have been used for heterologous gene expression for nearly four decades, providing foundational insights into RNA virus replication, host interactions, and genome engineering.
Dan T. Boghici, Danni Yong, Silvia M. Vidal, GuanQun Liu   +3 more
doaj   +1 more source

Molecular insights and translational opportunities to enhance heat tolerance in rice

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract Heat stress is an increasingly serious threat to rice (Oryza sativa L.) productivity, yet the genetic and regulatory architecture underlying thermotolerance remain poorly resolved and fragmented across studies. Earlier research focused on individual pathways or specific developmental stages; however, recent advances now support an integrated ...
Prabhat Rana, Chanderkant Chaudhary, Rajat Pruthi, Mansi Sharma, Bhupinderjeet Singh, Ravi Kiran Reddy Kondi, Mallesham Bulle, Prasanta K. Subudhi   +7 more
wiley   +1 more source

Diagnosis and management of equine metabolic syndrome

Equine Veterinary Education, Volume 38, Issue 9, Page 471-480, September 2026.
Summary Equine metabolic syndrome (EMS) is a prevalent endocrine disorder that increases the risk of hyperinsulinaemia‐associated laminitis (HAL), the most common and clinically significant form of laminitis. The central pathological feature of EMS is insulin dysregulation (ID), which encompasses basal or postprandial hyperinsulinaemia and tissue ...
F. R. Bertin
wiley   +1 more source

Partial N-terminal amino acid sequences of three nonstructural proteins of two flaviviruses

, 1986
Partial N-terminal amino acid sequences for the three largest nonstructural proteins of two flaviviruses, yellow fever virus and St. Louis encephalitis virus, have been obtained.
Schlesinger, Jacob J., Ruedi Aebersold, Strauss, James H., Dennis W. Trent, David B. Teplow, Aebersold, Ruedi, Pata, Janice, Vorndam, A. Vance, Rice, Charles M., James H. Strauss, Michael W. Brandriss, Charles M. Rice, John R. Bell, Trent, Dennis W., Brandriss, Michael W., Janice Pata, Bell, John R., Teplow, David B., A. Vance Vorndam, Jacob J. Schlesinger   +19 more
core   +1 more source

H5N1 Clade 2.3.4.4b Infections in Domestic Cats During an Avian Influenza Outbreak in Italy: Implications for One Health Surveillance

Influenza and Other Respiratory Viruses, Volume 20, Issue 9, September 2026.
ABSTRACT Background H5Nx goose/Guangdong (Gs/GD) lineage highly pathogenic avian influenza (HPAI) viruses pose a significant public health threat due to their global spread, mutation accumulation, and expanding host range. The descendant clade 2.3.4.4b has been causing widespread infections in birds and increasing spillover events in mammals.
Giulia D'Annunzio, Ana Moreno, Giovanni Tosi, Patrizia Bassi, Alessio Bortolami, Giuseppe Diegoli, Alessandra Drago, Alice Fusaro, Luca Gelmini, Lucia Rita Gibelli, Tiziana Lazzarotto, Elisabetta Lilliu, Luisa Loli Piccolomini, Andrea Maroni, Enrica Martini, Giulio Matteo, Giovanna Mattei, Luisa Vera Muscatello, Isabella Monne, Elisa Palumbo, Giorgia Prezzemolo, Valentina Ravaioli, Davide Resi, Luigi Ruocco, Michele Ottavio Sabatino, Enrico Savegnago, Marco Sordilli, Calogero Terregino, Clara Tolini, Giuseppe Merialdi   +29 more
wiley   +1 more source

Conjugation's Toolkit: the Roles of Nonstructural Proteins in Bacterial Sex. [PDF]

J Bacteriol, 2023
Cooke MB, Herman C.
europepmc   +1 more source

Flavivirus nonstructural proteins and replication complexes as antiviral drug targets. [PDF]

Curr Opin Virol, 2023
van den Elsen K, Chew BLA, Ho JS, Luo D.
europepmc   +1 more source