Results 51 to 60 of about 19,166 (219)

Gaining insights into MmpL3: combining structural and computational approaches to unlock transport and inhibitor‐binding mechanisms

Acta Crystallographica Section D, Volume 82, Issue 5, Page 550-570, May 2026.
This study investigates the mycobacterial membrane protein MmpL3, a key target for new antituberculosis drugs, by combining high‐resolution crystallography and computational simulations. It reveals how the inhibitor UPAR‐1109 binds to MmpL3, providing detailed insights into the function and flexibility of the protein and supporting the rational design ...
Satoshi Murakami, Domenico Marson, Eiki Yamashita, Bruno Broshka, Ui Okada, Maho Aoki, Giannamaria Annunziato, Erik Laurini, Emanuele Carosati, Marco Pieroni   +9 more
wiley   +1 more source

Bronchiectasis:a case-based approach to investigation and management [PDF]

, 2018
Bronchiectasis is a chronic respiratory disease characterised by a syndrome of productive cough and recurrent respiratory infections due to permanent dilatation of the bronchi.
Agarwal, Agarwal, Bonaiti, Cartier, Chu, Cole, Erasmus, Farrell, Greenberger, Gremmo, Hosie, James D. Chalmers, Martina Contarini, Mirsaeidi, Neeld, Nicolini, Shapiro, Simon Finch   +17 more
core   +3 more sources

Nontuberculous Mycobacteria-Overview

Microbiology Spectrum, 2017
ABSTRACT Nontuberculous mycobacteria (NTM) are emerging pathogens that affect both immunocompromised and immunocompetent patients. The development of molecular methods has allowed the characterization of new species and the identification of NTM to the precise species and subspecies levels.
openaire   +2 more sources

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, Volume 15, Issue 14, 10 April 2026.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Isolation Prevalence of Pulmonary Nontuberculous Mycobacteria in Ontario in 2007

Canadian Respiratory Journal, 2011
BACKGROUND: The reported prevalence of pulmonary nontuberculous mycobacteria (NTM) infections is increasing.
Mohammed Al Houqani, Frances Jamieson, Pamela Chedore, Mauli Mehta, Kevin May, Theodore K Marras   +5 more
doaj   +1 more source

Nontuberculous Mycobacteria, Botswana, 2011–2014

Emerging Infectious Diseases, 2019
We documented a 6-fold increase in the frequency of nontuberculous mycobacteria isolated from clinical samples in Botswana during 2011–2014. Because antituberculosis treatment is often initiated only on the basis of acid-fast bacilli smear-positive ...
Bontle Mbeha, Madisa Mine, Modisa Sekhamo Motswaledi, John Dewar   +3 more
doaj   +1 more source

Catheter‐related blood stream infection caused by Mycobacterium chelonae in a child with myeloid leukemia associated with Down syndrome

Clinical Case Reports, 2021
Rapidly growing nontuberculous mycobacteria should be considered if GPRs gram‐positive rods are detected in blood cultures 2‐3 days after the blood sample collection.
Tomoko Fujikawa, Suguru Uemura, Yuya Aoto, Yoshinori Nambu, China Nagano, Naoko Nakatani, Nanako Nino, Nobuyuki Yamamoto, Takeshi Mori, Noriyuki Nishimura, Kazumoto Iijima   +10 more
doaj   +1 more source

Chronic breast abscess due to Mycobacterium fortuitum: a case report [PDF]

, 2011
Introduction Mycobacterium fortuitum is a rapidly growing group of nontuberculous mycobacteria more common in patients with genetic or acquired causes of immune deficiency.
Dibendu Betal, Fiona A MacNeill
core   +2 more sources

Serial and Parallel Testing Strategies for Johne's Disease: Effects on Milk Production Traits and Milk Income on New Zealand Dairy Cattle

New Zealand Journal of Agricultural Research, Volume 69, Issue 2, April 2026.
The suboptimal accuracy of current diagnostic tests necessitates alternative testing strategies to improve the detection of Johne's disease. We studied parallel and serial testing strategies to quantify the association between milk production and Johne's disease status. For this, two commercial Johne's disease Enzyme‐Linked Immunosorbent Assay, ELISAs,
Venkatesh K. M., Nicolas Lopez‐Villalobos, Sandeep K. Gupta, Garry B. Udy, Richard Laven, Venkata Sayoji Rao Dukkipati   +5 more
wiley   +1 more source

The Changing Pattern of Nontuberculous Mycobacterial Disease

Canadian Journal of Infectious Diseases, 2003
Nontuberculous mycobacteria are human opportunistic pathogens whose source of infection is the environment. These include both slow-growing (eg, Mycobacterium kansasii and Mycobacterium avium) and rapid-growing (eg, Mycobacterium abscessus and ...
Joseph O Falkinham
doaj   +1 more source