Results 181 to 190 of about 3,775 (250)
[Molecular-biochemical mechanisms of the effects of nootropic agents].
Biulleten' eksperimental'noi biologii i meditsiny, 1990 It is a known fact that prophylactic hypodermic injection of non-typical lithonite tranquillizer in the day's dose of 30 mg/kg during 10 days prevents the exhaustion of antioxidant system of the body, normalizes qualitative and quantitative correlation of separate fractions of phospholipids, stabilizes the permeability of erythrocytic membranes and ...
Kresiun Vi, Rozhkovskiĭ IaV
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Electroencephalographic model for measuring the antihypoxic properties of nootropic agents in rats
Pharmacological Research Communications, 1988 A Nencioni, Giulio Galliani
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[The original novel nootropic and neuroprotective agent noopept].
Eksperimental'naia i klinicheskaia farmakologiia, 2003The paper describes pharmacological properties of the new nootropic drug noopept created using an original approach based on the imitation of a nonpeptide nootrope structure by means of the short-peptide design. In particular, the structure of pyracetam was designed using dipeptide nootropes.
R U, Ostrovskaia +3 more
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Current Trends in the Animal Models for Screening of Nootropic Agents: A Systematic Review
Current Reviews in Clinical and Experimental Pharmacology, 2023Background:Deficits in cognitive functions are observed in various diseases. The term “nootropics” refers to the compounds that increase mental functions, including memory, motivation, concentration and attention. Given the complexity and vastness of the processes involved in cognition, developing an appropriate animal model for the screening of ...
Seema Jain, Shubhima Grover
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Investigations on the binding properties of the nootropic agent pyroglutamic acid.
Drugs under experimental and clinical research, 1990The two stereoisomers of pyroglutamic acid (PCA), a nootropic or cognition-enhancing agent, and classic reference compounds were investigated for their ability to interact with 27 neurotransmitter receptors and drug binding sites prepared from selected areas of the central nervous system and labelled with high affinity and selectivity with specific ...
D, Barone, G, Spignoli
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[Effect of nootropic agents on impulse activity of cerebral cortex neurons].
Eksperimental'naia i klinicheskaia farmakologiia, 2002The effect of nootropes (semax, mexidol, and GVS-111) on the activity of individual neurons in various cerebral cortex regions was studied by microelectrode and microionophoresis techniques in cats immobilized by myorelaxants. It was established that the inhibiting effect of mexidol upon neurons in more than half of cases is prevented or significantly ...
V V, Iasnetsov +6 more
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Modern approach to development of nootropic agents based on γ-aminobutyric acid (review)
Pharmaceutical Chemistry Journal, 1981 V. M. Kopelevich +2 more
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Senile dementia of the Alzheimer type treated with aniracetam: a new nootropic agent
Psychopharmacology, 1987Forty-four patients with senile dementia of the Alzheimer type were randomly allocated into double-blind treatment with either aniracetam (RO 13-5057) 1 g or placebo daily for 3 months. Neurological examinations were made before and after treatment and psychometric tests were performed before and after 1 month's and after 3 month's treatment. Treatment
L B, Sourander +4 more
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Pharmacokinetics of a nootropic agent, BMY-21502, and its metabolites in beagle dogs
European Journal of Drug Metabolism and Pharmacokinetics, 1998A preliminary investigation into the pharmacokinetics of BMY-21502, a nootropic agent, and two of its metabolites, BMY-42191 and BMY-40440, was performed in 4 beagle dogs. Following oral dosing of a solution of BMY-21502 (0.61 mmoles), plasma samples were obtained for 24 h and analyzed for the three analytes by a validated HPLC assay.
N, Srinivas, S, Kaul
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[Analytic evaluation of potential nootropic agents].
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 2004The paper deals with analytical evaluation of newly prepared substances, derivatives of N-(4-alkoxy-phenyl)-2-(2-oxo-azepan-1-yl)-acetamide. The substances are a homological series (methyl- to hexyl-). The purity of the substances was verified by thin-layer adsorption chromatography, and the principal physical characteristics--melting point and ...
R, Opatrilová, P, Sokolová
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