Results 161 to 170 of about 2,327 (198)

Pharmacokinetics of a nootropic agent, BMY-21502, and its metabolites in beagle dogs

European Journal of Drug Metabolism and Pharmacokinetics, 1998
A preliminary investigation into the pharmacokinetics of BMY-21502, a nootropic agent, and two of its metabolites, BMY-42191 and BMY-40440, was performed in 4 beagle dogs. Following oral dosing of a solution of BMY-21502 (0.61 mmoles), plasma samples were obtained for 24 h and analyzed for the three analytes by a validated HPLC assay.
N, Srinivas, S, Kaul
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Senile dementia of the Alzheimer type treated with aniracetam: a new nootropic agent

Psychopharmacology, 1987
Forty-four patients with senile dementia of the Alzheimer type were randomly allocated into double-blind treatment with either aniracetam (RO 13-5057) 1 g or placebo daily for 3 months. Neurological examinations were made before and after treatment and psychometric tests were performed before and after 1 month's and after 3 month's treatment. Treatment
L B, Sourander, R, Portin, P, Mölsä, A, Lahdes, U K, Rinne   +4 more
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[Analytic evaluation of potential nootropic agents].

Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 2004
The paper deals with analytical evaluation of newly prepared substances, derivatives of N-(4-alkoxy-phenyl)-2-(2-oxo-azepan-1-yl)-acetamide. The substances are a homological series (methyl- to hexyl-). The purity of the substances was verified by thin-layer adsorption chromatography, and the principal physical characteristics--melting point and ...
R, Opatrilová, P, Sokolová
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[Facilitation of evoked transcallosal responses by nootropic agents].

Biomedica biochimica acta, 1985
The effect of nootropic drugs was investigated by studying their influences on transcallosal responses in rats. Piracetam, meclofenoxate, vinpocetin, pyritinol, orotic acid and dihydroergotoxine as well as its components dihydroergocornine and dihydroergocrytpine enhance in a dose dependent manner the amplitudes of transcallosal responses.
U, Kirsch, J, Schmidt
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[Effect of nootropic agents on impulse activity of cerebral cortex neurons].

Eksperimental'naia i klinicheskaia farmakologiia, 2002
The effect of nootropes (semax, mexidol, and GVS-111) on the activity of individual neurons in various cerebral cortex regions was studied by microelectrode and microionophoresis techniques in cats immobilized by myorelaxants. It was established that the inhibiting effect of mexidol upon neurons in more than half of cases is prevented or significantly ...
V V, Iasnetsov, V A, Pravdivtsev, I N, Krylova, S B, Kozlov, N A, Provornova, Iu V, Ivanov, V V, Iasnetsov   +6 more
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[Molecular-biochemical mechanisms of the effects of nootropic agents].

Biulleten' eksperimental'noi biologii i meditsiny, 1990
It is a known fact that prophylactic hypodermic injection of non-typical lithonite tranquillizer in the day's dose of 30 mg/kg during 10 days prevents the exhaustion of antioxidant system of the body, normalizes qualitative and quantitative correlation of separate fractions of phospholipids, stabilizes the permeability of erythrocytic membranes and ...
V I, Kresiun, Ia V, Rozhkovskiĭ
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Memory effects of the combination of medazepam with nootropic agents.

Acta physiologica et pharmacologica Bulgarica, 1989
Experiments were made on rats using step-through passive avoidance method to study the effect of the benzodiazepine medazepam (Mz) on the retention of the memory traces during tests on the 3rd hour, 24th hour and 7th day after training, as well as the influencing of this effect by the nootropic agents meclofenoxate (Mf), aniracetam (Anc) and Euclidan ...
S, Rousseva, V V, Petkov, V D, Petkov, T A, Voronina, L N, Nerobkova, I A, Ivanova, V, Stoyanova   +6 more
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X-ray, NMR and theoretical studies of the structure and conformation of the nootropic agent tenilsetam

European Journal of Medicinal Chemistry, 1991
Abstract The conformational properties of the nootropic agent Tenilsetam (3-(2-thienyl)-2-piperazinone) have been assessed in the solid, liquid and isolated state by X-ray diffraction, NMR spectroscopy ( 1 H, 13 C) and quantum chemical calculations (MO semi-quantitative PM-3 method), respectively.
AMATO, Maria Emanuela, BANDOLI G, GRASSI, Antonio, MARLETTA A, NICOLINI M, PERLY B.   +5 more
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Effect of a new nootropic agent, CGS 5649B, on cognition, function, and behavior in dementia

Journal of General Internal Medicine, 1993
To determine the efficacy of CGS 5649B, the authors conducted a series of randomized, double-masked, single-subject studies using pairs of treatment periods, each pair including four weeks of active drug administration and four weeks of placebo administration.
D W, Molloy, G H, Guyatt, T, Standish, A, Willan, W, McIlroy, J, D'Souza, G, Brown, C, Mondadori   +7 more
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Antidepressant activities of WEB 1881, a new nootropic agent.

Polish journal of pharmacology and pharmacy, 1990
The central action, particularly potential antidepressant activity of WEB 1881, a new nootropic drug related to piracetam, was investigated in rats and mice. WEB 1881 antagonizes the reserpine- and apomorphine-induced hypothermia, potentiates the behavioral effect of DOPA and dihydroxyphenylserine, as well as the TRH-induced hyperthermia. Piracetam was
J, Maj, Z, Rogóz, G, Skuza, H, Sowińska, G, Nowak   +4 more
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