Results 11 to 20 of about 3,775 (250)

Design, Synthesis, and Preliminary Pharmacological Evaluation of 1,4-Diazabicyclo[4.3.0]nonan-9-ones as a New Class of Highly Potent Nootropic Agents [PDF]

, 2000
Dina Manetti, Carla Ghelardini, Alessandro Bartolini, Cristina Bellucci, Silvia Dei, Nicoletta Galeotti, Fulvio Gualtieri, María Novella Romanelli, Serena Scapecchi, Elisabetta Teodori   +9 more
openalex   +4 more sources

Flavonoid Derivatives as Potential Cholinesterase Inhibitors in Scopolamine-Induced Amnesic Mice: An In Vitro, In Vivo and Integrated Computational Approach

Brain Sciences, 2022
Flavonoids are one of the most exciting types of phenolic compounds with a wide range of bioactive benefits. A series of flavone derivatives (F1–F5) were previously synthesized from substituted O-hydroxy acetophenone and substituted chloro-benzaldehydes.
Fakhria A. Al-Joufi, Syed Wadood Ali Shah, Mohammad Shoaib, Mehreen Ghias, Shafiullah, Atif Ali Khan Khalil, Syed Babar Jamal, Syed Muhammad Hassan Shah, Muhammad Zahoor   +8 more
doaj   +1 more source

Novel Sunifiram-carbamate hybrids as potential dual acetylcholinesterase inhibitor and NMDAR co-agonist: simulation-guided analogue design and pharmacological screening

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
An efficient method for synthesising NMDAR co-agonist Sunifiram (DM235), in addition to Sunifram-carbamate and anthranilamide hybrids, has been developed in high yields via protecting group-free stepwise unsymmetric diacylation of piperazine using N ...
Khalid A. Agha, Nader E. Abo-Dya, Abdul Rashid Issahaku, Clement Agoni, Mahmoud E. S. Soliman, Eatedal H. Abdel-Aal, Zakaria K. Abdel-Samii, Tarek S. Ibrahim   +7 more
doaj   +1 more source

The use of Thiocetam in the complex therapy of combat-related brain contusion

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2023
Each patient presents a unique set of characteristics and challenges when it comes to acute cerebral ischemia resulting from craniocerebral injury.
I. F. Bielenichev, K. Yu. Nerianov, V. I. Chernii, D. A. Sereda, L. I. Kucherenko, N. V. Derevianko, К. І. Kandybei   +6 more
doaj   +1 more source

Comparative analysis of nootropic means of consumption in Ukraine, Estonia and Norway

Фармацевтичний журнал, 2020
Cerebrovascular disease develops in neurodegenerative, vascular or cerebrovascular diseases of the brain. For their treatment, nootropic agents have neurotrophic, neuroprotective effects, increase brain energy exchange and cerebral circulation.
O. V. Tkachova, L. V. Iakovlieva, Ya. O. Butko   +2 more
doaj   +1 more source

Experimental substantiation of the expediency of the combined use of piracetam and metformin for pharmacological correction of cognitive disorders in conditions of prolonged hyperglycemia

Medičnì Perspektivi, 2020
Chronic hyperglycemia, insulin resistance, endothelial dysfunction, and disturbance of the integrity of the blood-brain barrier are considered as strategically important links in the development of cognitive deficits in diabetic encephalopathy.
А. E. Lievykh, N. S. Bondarenko, S. N. Dronov, V. I. Mamchur, I. V. Tverdokhlib, V. I. Zhyliuk   +5 more
doaj   +1 more source

Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach

Pharmaceutics, 2020
In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter
Xavier Buol, Koen Robeyns, Camila Caro Garrido, Nikolay Tumanov, Laurent Collard, Johan Wouters, Tom Leyssens   +6 more
doaj   +1 more source

Phytotherapeutic Approaches to the Prevention of Age-Related Changes and the Extension of Active Longevity

Molecules, 2022
Maintaining quality of life with an increase in life expectancy is considered one of the global problems of our time. This review explores the possibility of using natural plant compounds with antioxidant, anti-inflammatory, anti-glycation, and anti ...
Olga Babich, Viktoria Larina, Svetlana Ivanova, Andrei Tarasov, Maria Povydysh, Anastasiya Orlova, Jovana Strugar, Stanislav Sukhikh   +7 more
doaj   +1 more source

Relative Efficacy of Piracetam, Modafinil and Citicoline on Cognitive Function in an Animal Model [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Nootropic drugs or cognitive enhancers are pharmacological agents that improve cognitive function and memory by various mechanisms. Drugs like piracetam, modafinil and citicoline have been used as nootropic agents.
Farrukh Ahmad, Veena Nayak, Chaitanya Malalur, Rinz Mathew, Amruta Tripathy, Kurady Laxminarayana Bairy   +5 more
doaj   +1 more source

Sports Supplement Analysis Survey for the Prevalence of WADA Prohibited Substances in the Australian Online Marketplace. [PDF]

Drug Test Anal
A survey of 200 sports supplements purchased online in Australia and analysed for WADA Prohibited Substances. Athlete education regarding the use of sports supplements remains a high priority as 35% of the products contained WADA Prohibited Substances. ABSTRACT Sports supplements are used extensively by people involved in competitive sports. However, a
Barker L, Cawley A, Speers N, Knowler K, Chilman K.   +4 more
europepmc   +2 more sources