Results 11 to 20 of about 5,409,842 (383)

Efflux pump inhibitory potential of indole derivatives as an arsenal against norA over-expressing Staphylococcus aureus

Microbiology Spectrum, 2023
NorA, an extensively studied efflux pump in Staphylococcus aureus, has been connected to fluoroquinolone, antiseptic, and disinfection resistance. Several studies have also emphasized how efflux pumps, including NorA, function as the first line of ...
Nishtha Chandal, Rushikesh Tambat, Ritu Kalia, Gautam Kumar, Nisha Mahey, Sanjay Jachak, Hemraj Nandanwar   +6 more
doaj   +2 more sources

Computational Insights and In Vitro Validation of Antibacterial Potential of Shikimate Pathway-Derived Phenolic Acids as NorA Efflux Pump Inhibitors

Molecules, 2022
The expression of the efflux pump systems is the most important mechanism of antibiotic resistance in bacteria, as it contributes to reduced concentration and the subsequent inactivity of administered antibiotics.
Karishma Singh, Roger M. Coopoosamy, Njabulo J. Gumede, Saheed Sabiu   +3 more
doaj   +2 more sources

Prenylated isoflavonoids from Fabaceae against the NorA efflux pump in Staphylococcus aureus

Scientific Reports, 2023
Overexpression of NorA efflux pumps plays a pivotal role in the multidrug-resistance mechanism in S. aureus. Here, we investigated the activities of prenylated isoflavonoids, present in the legume plant family (Fabaceae), as natural efflux pump ...
Marina Ika Irianti, Jean-Paul Vincken, Sarah van Dinteren, Ellen ter Beest, Klaas Martinus Pos, Carla Araya-Cloutier   +5 more
doaj   +2 more sources

Effect of Vitamin K₃ Inhibiting the Function of NorA Efflux Pump and Its Gene Expression on Staphylococcus aureus

Membranes, 2020
Resistance to antibiotics has made diseases that previously healed easily become more difficult to treat. Staphylococcus aureus is an important cause of hospital-acquired infections and multi-drug resistant.
Saulo R. Tintino, Veruska C. A. de Souza, Julia M. A. da Silva, Cícera Datiane de M. Oliveira-Tintino, Pedro S. Pereira, Tereza C. Leal-Balbino, Antonio Pereira-Neves, José P. Siqueira-Junior, José G. M. da Costa, Fabíola F. G. Rodrigues, Irwin R. A. Menezes, Gabriel C. A. da Hora, Maria C. P. Lima, Henrique D. M. Coutinho, Valdir Q. Balbino   +14 more
doaj   +2 more sources

Increased Expression of Efflux Pump norA Drives the Rapid Evolutionary Trajectory from Tolerance to Resistance against Ciprofloxacin in Staphylococcus aureus

Antimicrobial Agents and Chemotherapy, 2022
The intensively intermittent use of antibiotics promotes the rapid evolution of tolerance, which may lead to resistance acquisition in the following evolutionary trajectory. In addition to directly exporting antibiotics as an instant resistance strategy,
Xiaohui Yu, Zehua Hao, P L Liu, M. M. Liu, Lixiu Zhao, Xin Zhao   +5 more
openalex   +3 more sources

NorA and Tet38 efflux pumps enable <i>Staphylococcus aureus</i> survival in the cystic fibrosis airway environment, resistance to antibiotics, and coinfection with <i>Pseudomonas aeruginosa</i>. [PDF]

Antimicrob Agents Chemother
Efflux pumps play multiple roles in bacterial physiology, environmental adaptation, and antibiotic resistance. Early cystic fibrosis (CF) airway infections start with Staphylococcus aureus (SA), often later followed by Pseudomonas aeruginosa (PA ...
Truong-Bolduc QC, Wang Y, Lawton BG, Zweifach JJ, McDevitt GM, El Abdellaoui Y, Brown Harding H, Yonker LM, Rahme LG, Vyas JM, Hooper DC.   +10 more
europepmc   +2 more sources

Fighting Antimicrobial Resistance: Insights on How the Staphylococcus aureus NorA Efflux Pump Recognizes 2-Phenylquinoline Inhibitors by Supervised Molecular Dynamics (SuMD) and Molecular Docking Simulations

Journal of Chemical Information and Modeling, 2023
The superbug Staphylococcus aureus (S. aureus) exhibits several resistance mechanisms, including efflux pumps, that strongly contribute to antimicrobial resistance. In particular, the NorA efflux pump activity is associated with S.
Deborah Palazzotti, Tommaso Felicetti, S. Sabatini, S. Moro, M. Barreca, M. Sturlese, Andrea Astolfi   +6 more
semanticscholar   +1 more source

Valencene, Nootkatone and Their Liposomal Nanoformulations as Potential Inhibitors of NorA, Tet(K), MsrA, and MepA Efflux Pumps in Staphylococcus aureus Strains

Pharmaceutics, 2023
Valencene and nootkatone are aromatic sesquiterpenes with known biological activities, such as antimicrobial, antioxidant, anti-inflammatory, and antitumor.
C. D. M. Oliveira-Tintino, Jorge Ederson Gonçalves Santana, Gabriel Gonçalves Alencar, Gustavo Miguel Siqueira, Sheila Alves Gonçalves, S. Tintino, I. Menezes, J. P. V. Rodrigues, Vanessa Barbosa Pinheiro Gonçalves, Roberto Nicolete, J. Ribeiro-Filho, T. G. da Silva, H. Coutinho   +12 more
semanticscholar   +1 more source

Machine learning-based Sr isoscape of southern Sardinia: A tool for bio-geographic studies at the Phoenician-Punic site of Nora

PLoS ONE, 2023
Since prehistoric times, the island of Sardinia—in the western Mediterranean—has played a leading role in the dynamics of human population and mobility, in the circulation of raw materials and artefacts, idioms and customs, of technologies and ideas that
Melania Gigante, Alessandro Mazzariol, J. Bonetto, Elena Armaroli, A. Cipriani, F. Lugli   +5 more
semanticscholar   +1 more source

Resveratrol as an Inhibitor of the NorA Efflux Pump and Resistance Modulator in Staphylococcus aureus

Antibiotics, 2023
Staphylococcus aureus can exhibit resistance to various antibiotics. Among its resistance mechanisms, the active efflux of antibiotics can be seen as relevant.
Madalena Santos, Raquel Santos, Pedro F. Soeiro, S. Silvestre, Susana Ferreira   +4 more
semanticscholar   +1 more source