Results 31 to 40 of about 876,870 (204)

Molecular features of prenylated (iso)flavonoids from Fabaceae in relation to their potential NorA inhibition in Staphylococcus aureus

open access: yesFrontiers in Pharmacology
BackgroundThe overexpression of the NorA efflux pump is known to be an important factor in the antimicrobial resistance mechanism of Staphylococcus aureus. Therefore, NorA inhibition can help disarm this pathogen and tackle antimicrobial resistance.
Marina Ika Irianti   +5 more
doaj   +1 more source

Deutsche Arbeitsmarktregionen – Neuabgrenzung nach den Kreisgebietsreformen 2007–2011

open access: yesRaumforschung und Raumordnung, 2012
Studies in Regional Economics require functional regions as statistical units. Regional labour markets are characterized by close commuter links in the regional labour markets and high seclusion towards other regional labour markets. From time to time a
Reinhold Kosfeld, Alexander Werner
doaj   +1 more source

Cardiac bridging integrator 1 gene therapy rescues chronic non-ischemic heart failure in minipigs

open access: yesnpj Regenerative Medicine
Heart failure (HF) is a major cause of mortality and morbidity worldwide, yet with limited therapeutic options. Cardiac bridging integrator 1 (cBIN1), a cardiomyocyte transverse-tubule (t-tubule) scaffolding protein which organizes the calcium handling ...
Jing Li   +12 more
doaj   +1 more source

AAV9-cBIN1 gene therapy rescues chronic heart failure due to ischemic cardiomyopathy in a canine model

open access: yesCommunications Medicine
Background Ischemic cardiomyopathy and resultant heart failure (HF) is a significant cause of morbidity and mortality worldwide. Downregulation of cardiac bridging integrator 1 (cBIN1), a membrane scaffolding protein responsible for organizing t-tubules ...
Muhammad S. Khan   +16 more
doaj   +1 more source

Effect of Vitamin K3 Inhibiting the Function of NorA Efflux Pump and Its Gene Expression on Staphylococcus aureus

open access: yesMembranes, 2020
Resistance to antibiotics has made diseases that previously healed easily become more difficult to treat. Staphylococcus aureus is an important cause of hospital-acquired infections and multi-drug resistant.
Saulo R. Tintino   +14 more
doaj   +1 more source

Interview with Nora Lafi

open access: yes, 2020
Interview with PD Dr. Nora LAfi, fellow of the KFG "Religion and Urbanity: Reciprocal Formations" (DFG, FOR 2779)
Christ, Martin
core  

Interview with Nora Woody

open access: yes, 2003
Nora Woody offers her insight on the artist and craftmanship of Arval ...
Woody, Nora
core   +2 more sources

Prenylated isoflavonoids from Fabaceae against the NorA efflux pump in Staphylococcus aureus

open access: yesScientific Reports, 2023
Overexpression of NorA efflux pumps plays a pivotal role in the multidrug-resistance mechanism in S. aureus. Here, we investigated the activities of prenylated isoflavonoids, present in the legume plant family (Fabaceae), as natural efflux pump ...
Marina Ika Irianti   +5 more
doaj   +1 more source

6-gingerol enhances ciprofloxacin efficacy by inhibiting NorA efflux pump in Staphylococcus aureus

open access: yesThe Microbe
The drug efflux mechanism adopted by Staphylococcus aureus helps it in its survival under antibiotic pressure. The efflux pump NorA, a member of the MFS superfamily, effluxes out fluoroquinolones, biocides, quaternary ammonium compounds, and anti ...
Shashikanta Sau   +4 more
doaj   +1 more source

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