Results 11 to 20 of about 5,649,103 (354)

Efflux pump inhibitory potential of indole derivatives as an arsenal against norA over-expressing Staphylococcus aureus

Microbiology Spectrum, 2023
NorA, an extensively studied efflux pump in Staphylococcus aureus, has been connected to fluoroquinolone, antiseptic, and disinfection resistance. Several studies have also emphasized how efflux pumps, including NorA, function as the first line of ...
Nishtha Chandal, Rushikesh Tambat, Ritu Kalia, Gautam Kumar, Nisha Mahey, Sanjay Jachak, Hemraj Nandanwar   +6 more
doaj   +2 more sources

Computational Insights and In Vitro Validation of Antibacterial Potential of Shikimate Pathway-Derived Phenolic Acids as NorA Efflux Pump Inhibitors

Molecules, 2022
The expression of the efflux pump systems is the most important mechanism of antibiotic resistance in bacteria, as it contributes to reduced concentration and the subsequent inactivity of administered antibiotics.
Karishma Singh, Roger M. Coopoosamy, Njabulo J. Gumede, Saheed Sabiu   +3 more
doaj   +2 more sources

Effect of Vitamin K₃ Inhibiting the Function of NorA Efflux Pump and Its Gene Expression on Staphylococcus aureus

Membranes, 2020
Resistance to antibiotics has made diseases that previously healed easily become more difficult to treat. Staphylococcus aureus is an important cause of hospital-acquired infections and multi-drug resistant.
Saulo R. Tintino, Veruska C. A. de Souza, Julia M. A. da Silva, Cícera Datiane de M. Oliveira-Tintino, Pedro S. Pereira, Tereza C. Leal-Balbino, Antonio Pereira-Neves, José P. Siqueira-Junior, José G. M. da Costa, Fabíola F. G. Rodrigues, Irwin R. A. Menezes, Gabriel C. A. da Hora, Maria C. P. Lima, Henrique D. M. Coutinho, Valdir Q. Balbino   +14 more
doaj   +2 more sources

Safe-NORA: Safe Reinforcement Learning-based Mobile Network Resource Allocation for Diverse User Demands

International Conference on Information and Knowledge Management, 2023
As mobile communication technologies advance, mobile networks become increasingly complex, and user requirements become increasingly diverse. To satisfy the diverse demands of users while improving the overall performance of the network system, the ...
Wenzhen Huang, Tong Li, Yuting Cao, Zhentong Lyu, Yanping Liang, Li Yu, Depeng Jin, Junge Zhang, Yong Li   +8 more
semanticscholar   +1 more source

Valencene, Nootkatone and Their Liposomal Nanoformulations as Potential Inhibitors of NorA, Tet(K), MsrA, and MepA Efflux Pumps in Staphylococcus aureus Strains

Pharmaceutics, 2023
Valencene and nootkatone are aromatic sesquiterpenes with known biological activities, such as antimicrobial, antioxidant, anti-inflammatory, and antitumor.
C. D. M. Oliveira-Tintino, Jorge Ederson Gonçalves Santana, Gabriel Gonçalves Alencar, Gustavo Miguel Siqueira, S. A. Gonçalves, S. Tintino, I. Menezes, J. P. V. Rodrigues, Vanessa Barbosa Pinheiro Gonçalves, Roberto Nicolete, J. Ribeiro-Filho, T. G. da Silva, H. Coutinho   +12 more
semanticscholar   +1 more source

Fighting Antimicrobial Resistance: Insights on How the Staphylococcus aureus NorA Efflux Pump Recognizes 2-Phenylquinoline Inhibitors by Supervised Molecular Dynamics (SuMD) and Molecular Docking Simulations

Journal of Chemical Information and Modeling, 2023
The superbug Staphylococcus aureus (S. aureus) exhibits several resistance mechanisms, including efflux pumps, that strongly contribute to antimicrobial resistance. In particular, the NorA efflux pump activity is associated with S.
Deborah Palazzotti, Tommaso Felicetti, S. Sabatini, S. Moro, M. Barreca, M. Sturlese, Andrea Astolfi   +6 more
semanticscholar   +1 more source

Prenylated isoflavonoids from Fabaceae against the NorA efflux pump in Staphylococcus aureus

Scientific Reports, 2023
Overexpression of NorA efflux pumps plays a pivotal role in the multidrug-resistance mechanism in S. aureus . Here, we investigated the activities of prenylated isoflavonoids, present in the legume plant family (Fabaceae), as natural efflux pump ...
Marina Ika Irianti, J. Vincken, Sarah van Dinteren, Ellen ter Beest, K. M. Pos, Carla Araya-Cloutier   +5 more
semanticscholar   +1 more source

Inhibition of the norA gene expression and the NorA efflux pump by the tannic acid

Scientific Reports, 2023
The NorA efflux pump of Staphylococcus aureus is known to play a major role in the development of resistance against quinolone drugs by reducing their concentration inside target pathogens.
S. Tintino, P. Wilairatana, Veruska Cíntia Alexandrino de Souza, Julia Mariana Assis da Silva, P. S. Pereira, Cícera Datiane de Morais Oliveira-Tintino, Y. D. de Matos, J. Júnior, V. de Queiroz Balbino, J. P. Siqueira-Júnior, I. Menezes, A. Siyadatpanah, H. D. M. Coutinho, T. C. L. Balbino   +13 more
semanticscholar   +1 more source

Tackling multidrug-resistant Staphylococcus aureus by natural products and their analogues acting as NorA efflux pump inhibitors.

Bioorganic & Medicinal Chemistry, 2023
Staphylococcus aureus (S. aureus) is a pathogen responsible for various community and hospital-acquired infections with life-threatening complications like bacteraemia, endocarditis, meningitis, liver abscess, and spinal cord epidural abscess ...
Gautam Kumar, Asha Kiran Tudu
semanticscholar   +1 more source

Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus

Nature Chemical Biology, 2022
Membrane protein efflux pumps confer antibiotic resistance by extruding structurally distinct compounds and lowering their intracellular concentration.
D. Brawley, David B. Sauer, Jianping Li, Xuhui Zheng, A. Koide, Ganesh Suresh Jedhe, Tiffany Suwatthee, Jinmei Song, Zheng Liu, P. Arora, S. Koide, V. Torres, Da-Neng Wang, N. Traaseth   +13 more
semanticscholar   +1 more source