Results 111 to 120 of about 7,845 (216)

Recent optical approaches for anatomical and functional dissection of neuron–astrocyte circuitry

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend This review summarises novel optical approaches to deciphering structural and functional wiring diagrams of neuron–astrocyte circuits in the brain. There are three groups: the anatomical proximity assay, transsynaptic viral tracing and the functional connection assay. The FRET‐based neuron–astrocyte proximity assay allows mapping
Yoshiki Hatashita, Takafumi Inoue
wiley   +1 more source

Chemogenetic Control of Striatal Astrocytes Improves Parkinsonian Motor Deficits in Mice

open access: yesGlia, Volume 73, Issue 6, Page 1188-1202, June 2025.
Main Points Dopamine depletion reduces locomotion‐induced calcium activity in dorsal striatal astrocytes. Chemogenetic activation facilitates astrocyte locomotion responses and improves motor behavior in dopamine lesioned animals. ABSTRACT Parkinson's disease (PD) is characterized by the degeneration of dopaminergic nigrostriatal inputs, which causes ...
Wesley R. Evans   +7 more
wiley   +1 more source

Tonic Inhibition of Allergic Itch Signaling by the Descending Noradrenergic System in Mice

open access: yesJournal of Pharmacological Sciences, 2011
We investigated whether the descending noradrenergic system regulates allergic itch. Mosquito allergy of the hind paw elicited biting, an itch-related response, in sensitized mice.
Yoshikazu Gotoh   +3 more
doaj  

Case Series of Patients With FGFR1‐Related Pheochromocytoma and Paraganglioma With a Focus on Biochemical, Imaging Signatures and Treatment Options

open access: yesClinical Endocrinology, Volume 102, Issue 6, Page 626-634, June 2025.
ABSTRACT Pheochromocytoma and paraganglioma (together PPGL) are tumours with a high degree of heritability. Genetic landscape is divided into three clusters, cluster 1 (Krebs/pseudohypoxia signalling pathway), cluster 2 (kinase signalling pathway) and cluster 3 (Wnt signalling pathway).
Sakshi Jhawar   +5 more
wiley   +1 more source

THE EFFECTS OF NORADRENERGIC DENERVATION ON MUSCARINIC RECEPTORS OF SMOOTH MUSCLE [PDF]

open access: green, 1982
Thomas M. Bennett   +2 more
openalex   +1 more source

Pharmacokinetic Modeling and Model‐Based Hypothesis Generation for Dose Optimization of Clonidine in Neonates With Neonatal Opioid Withdrawal Syndrome

open access: yesClinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1254-1263, May 2025.
The No‐POPPY study (NCT03396588), a double‐blind, randomized trial compared morphine with clonidine therapy for neonatal opioid withdrawal syndrome (NOWS) and found that the duration of treatment was similar across groups. This is significant because perinatal use of morphine has the potential for neurodevelopmental consequences.
Fei Tang   +4 more
wiley   +1 more source

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