Results 131 to 140 of about 74,045 (223)

Pharmacologic MRI Brain Imaging Studies of Serotonin 5‐HT1 Receptor Agonists in Awake Mice

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Serotonin (5‐hydroxytryptamine, 5‐HT) type‐1 G protein‐coupled receptors are expressed throughout the central nervous system. 5‐HT1AR activation is the putative mechanism of approved drugs for generalized anxiety disorder and major depressive disorder and is being studied in the treatment of autism and neurological disorders.
Brittany M. Brems, Erin E. Sullivan, Ryan P. McGlynn, Praveen Kulkarni, Craig F. Ferris, Raymond G. Booth   +5 more
wiley   +1 more source

Early‐life Giardia infection and behavioural dysregulation in two dogs: A case‐based exploration of the gut microbiome–brain axis

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract This case report describes two dogs exhibiting severe behavioural problems, both diagnosed with early‐life giardiasis and raised in environments lacking adequate maternal care and socialisation. Both dogs experienced chronic gastrointestinal and dermatological issues, as well as prolonged early‐life stress, which likely contributed to ...
Daniëlle Hartman, Claudia M. Vinke, Silvia M. A. Gardeweg, Ineke R. van Herwijnen   +3 more
wiley   +1 more source

Enteric Nervous System Damage by Food Contaminants: A Pathway to Neurodegeneration?

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT The enteric nervous system (ENS), a key component of the gut–brain axis, has emerged as a critical player in the pathogenesis of Parkinson's disease (PD). It is the first neural system exposed to food contaminants (FCs)—a diverse group of ubiquitous toxic compounds fortuitously present in food derived from production, processing, storage, or ...
Helena Ramos, Ana Margarida Araújo, Isabel M. P. L. V. O. Ferreira, Miguel A. Faria   +3 more
wiley   +1 more source

Locus coeruleus MRI contrast is associated with cortical thickness in older adults

, 2020
Bachman, S., Dahl, M., Düzel, S., Garcia Forlim, C., Kühn, S., Lindenberger, U., Mather, M., Werkle-Bergner, M.   +7 more
core   +1 more source

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, Volume 183, Issue 10, Page 2177-2196, May 2026.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Effects of tapentadol on pain, motor symptoms and cognitive functions in Parkinson\u2019s disease [PDF]

, 2018
Background: Pain is a common and undertreated non-motor symptom in patients with Parkinson\u2019s disease (PD). Opioids have been seldom used in PD because they could worsen cognitive and motor functions.
Freo, Ulderico, Furnari, Maurizio, Ori, Carlo   +2 more
core  

Targeting the noradrenergic‐metabolic axis: A new strategy for sugar‐induced depression subtypes

British Journal of Pharmacology, Volume 183, Issue 9, Page 2099-2122, May 2026.
Abstract Background and Purpose Lifestyle is closely related to major depressive disorder (MDD). Given the growing focus on the impact of diet on mental health, this study examined how dietary habits affect the pathophysiology of MDD. Experimental Approach Health check‐up data were analysed. Mice received sucrose under chronic unpredictable mild stress
Takatoshi Sakata, Kazuo Kunisawa, Masaya Hasegawa, Yumiko Seto, Aoi Ogawa, Hitomi Kurahashi, Yasuko Yamamoto, Masao Takemura, Hidetoshi Matunami, Tomoya Sugai, Noriki Kutsumura, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri   +13 more
wiley   +1 more source

Matsupexole: A novel nonergot dopamine receptor agonist with sustained efficacy in a rat model of Parkinson's disease and limited off‐target activity

British Journal of Pharmacology, Volume 183, Issue 10, Page 2518-2532, May 2026.
Background and Purpose Dopamine receptor agonists, particularly targeting the dopamine D2L receptor (D2LR), have been used to treat Parkinson's disease (PD). However, valvular heart disease and somnolence, mainly caused by activating the serotonin 5‐HT2B receptor (5‐HT2BR) and dopamine D3 receptor (D3R), respectively, currently challenge their clinical
Takayuki Suzuki, Fumiki Oana, Masaki Oota, Yuma Handa, Osamu Kaminuma   +4 more
wiley   +1 more source

Who can safely discontinue lifelong follow‐up among patients with sporadic pheochromocytoma and paraganglioma?

Journal of Internal Medicine, Volume 299, Issue 5, Page 615-627, May 2026.
Abstract Background Current guidelines recommend at least 10 years of follow‐up for all pheochromocytoma and paraganglioma (PPGL) patients and lifelong monitoring for high‐risk individuals. Nonetheless, data identifying patients who may not require routine lifelong follow‐up are scarce. Methods Among 999 patients with PPGL, 703 who were non‐metastatic,
Min Jeong Park, Seung Shin Park, Won Woong Kim, Su‐Jin Kim, Yu‐Mi Lee, Kyu Eun Lee, Tae‐Yon Sung, Jae‐Kyung Won, Dong Eun Song, Jung‐Min Koh, Sara Talvacchio, Tamara Prodanov, Hussam Alkaissi, Karel Pacak, Seung Hun Lee, Jung Hee Kim   +15 more
wiley   +1 more source

Sleep Alters the Velocity of Physiological Brain Pulsations in Humans

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Sleep alters I/CSF oscillatory flow, driven by increased respiratory (29%) and vasomotor pulsation (21%) velocities, while cardiovascular pulsations decreased by (22%). Velocity is quantified using optical flow analysis of MREG data. Spectral power increases alongside these pulsations (spatial correlation, r = 0.35 and r = 0.39, respectively ...
Ahmed Elabasy, Heta Helakari, Tommi Väyrynen, Zalán Rajna, Niko Huotari, Lauri Raitamaa, Ville Isokoski, Matti Järvelä, Mika Kaakinen, Johanna Piispala, Mika Kallio, Vesa Korhonen, Tapio Seppänen, Vesa Kiviniemi   +13 more
wiley   +1 more source