Results 141 to 150 of about 74,045 (223)

Impact of early locus coeruleus lesions in the TgF344 Alzheimer's disease rat model

Alzheimer's &Dementia, Volume 22, Issue 4, -Not available-.
Abstract INTRODUCTION In murine models of Alzheimer's disease (AD), lesioning the locus coeruleus–norepinephrine (LC‐NE) system with DSP‐4 exacerbates AD‐like neuropathology and cognitive impairment. However, the impact of LC lesions during prodromal stages is poorly characterized. METHODS TgF344‐AD and wild‐type rats received monthly injections of DSP‐
Alexia E. Marriott, Jason P. Schroeder, Anu Korukonda, Brittany S. Pate, Katharine E. McCann, David Weinshenker, Michael A. Kelberman   +6 more
wiley   +1 more source

Editorial: Anatomy of Upper Airway and Neuronal Control of Pharyngeal Muscles in Obstructive Sleep Apnea

Frontiers in Neurology, 2019
Victor B. Fenik, Victor B. Fenik, Thomas Penzel, Atul Malhotra   +3 more
doaj   +1 more source

Attenuated pupillary response during visual search in preclinical Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 4, -Not available-.
Abstract INTRODUCTION The locus coeruleus is among the earliest brain regions affected by tau pathology in Alzheimer's disease (AD), but the functional impact is difficult to measure in vivo. Task‐evoked pupil dilation provides an index of locus coeruleus–norepinephrine function that might be altered in cognitively normal older adults with underlying ...
Elena K. Festa, William C. Heindel, Camille A. Marangi, Britney Escobedo, Douglas R. Galasko, David P. Salmon, Jingjing Zou, Diane M. Jacobs   +7 more
wiley   +1 more source

Locus coeruleus degeneration is associated with cortical tau deposition and cognitive decline in older adults at familial risk of Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION The locus coeruleus (LC) is among the first sites of tau pathology in Alzheimer's disease (AD) and may seed neocortical tau. METHODS We used longitudinal neuromelanin‐sensitive MRI to assess LC integrity in vivo in a cohort of cognitively unimpaired older adults with familial risk of AD in relation to tau and amyloid positron ...
Alfie Wearn, Kate M. Onuska, Hayley R. C. Shanks, Rahul Gaurav, Stéphane Lehéricy, Giulia Baracchini, Colleen Hughes, Jennifer Tremblay‐Mercier, Sridar Narayanan, John Breitner, Judes Poirier, Taylor W. Schmitz, Gary R. Turner, R. Nathan Spreng, for the PREVENT‐AD Research Group   +14 more
wiley   +1 more source

Drug‐Induced Raynaud's Phenomenon and Underlying Mechanism: A Disproportionality Analysis From the World Health Organization Pharmacovigilance Database

Arthritis &Rheumatology, Volume 78, Issue 4, Page 985-992, April 2026.
Objectives The aim of this study is to generate hypotheses about unknown drugs associated with the onset or worsening of Raynaud's phenomenon (RP) and to explore their potential pathophysiologic mechanisms through a mixed disproportionality/clustering analysis from the World Health Organization (WHO) pharmacovigilance database.
Alex Hlavaty, Loubna Dari, Jean‐Luc Cracowski, Matthieu Roustit, Charles Khouri   +4 more
wiley   +1 more source

Global and Regional Vigilance: Are There Two Types of Local Sleep?

Brain and Behavior, Volume 16, Issue 4, April 2026.
The term local sleep as it is used in the literature is confusing and probably consists of two types of brain states. The first one originates from increased activity in certain cortical areas during waking, resulting in increased activity in the slow‐waves range in that same area during subsequent NREM sleep. The second one consists of local states in
Tom Deboer
wiley   +1 more source

Sleep‐Dependent Clearance of Brain Metabolites via the Glymphatic System: Implications for Alzheimer's Pathophysiology

Brain and Behavior, Volume 16, Issue 4, April 2026.
Slow‐wave sleep promotes glymphatic transport through coordinated norepinephrine dynamics, vasomotion, and polarized AQP4‐dependent fluid exchange, thereby facilitating clearance of amyloid‐beta and tau. In contrast, sleep disruption, aging, vascular dysfunction, and AQP4 abnormalities impair this system and may accelerate Alzheimer‐related pathology ...
Farshad Zare, Gulnora Shakhmurova, Jasur Rizaev, Aseel Smerat, Rosull Saadoon Abbood, Vinay Patil, Manoj Kumar‐Mishra   +6 more
wiley   +1 more source

Decreased Myocardial 123I‐MIBG Uptake Without Sympathetic Denervation: An Autopsy Report of Autoimmune Autonomic Ganglionopathy

Brain and Behavior, Volume 16, Issue 4, April 2026.
Autopsy findings in autoimmune autonomic ganglionopathy (AAG) revealed preserved thoracic sympathetic ganglia, intact cardiac sympathetic fibers, and preserved enteric plexuses, providing pathological support for AAG as a channelopathy. Abstract Introduction Autoimmune autonomic ganglionopathy (AAG) is a rare disorder characterized by widespread ...
Daisuke Taniguchi, Kenya Nishioka, Yuta Ishiguro, Tsuyoshi Furuya, Takashi Ogawa, Kazunori Kajino, Yoshiaki Furukawa, Nobutaka Hattori   +7 more
wiley   +1 more source

Noradrenergic inhibition of definitive POMC neurons through direct and indirect mechanisms. [PDF]

J Neuroendocrinol
Norepinephrine and the α2‐adrenoceptor agonist UK 14,304 robustly inhibit definitive arcuate POMC neurons. Direct inhibition is mediated by ADRA2A‐dependent activation of potassium conductances, while additional indirect mechanisms also contribute. In vivo, inducible POMC‐specific Adra2a deletion minimally affects energy balance and modestly impairs ...
Lavoie O, Turmel A, Khouma A, Minbashi Moeini M, Liu C, Michael NJ, Caron A.   +6 more
europepmc   +2 more sources

Antinociceptive Effect of Cinnamaldehyde in Male Mice: Investigation of the Mechanisms of Action Through In Silico and In Vivo Approaches

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
ABSTRACT Cinnamaldehyde (CA), a major component of Cinnamomum spp. essential oils, has recognized bioactivity, including possible analgesic effects. However, its acute antinociceptive mechanisms remain unclear. This study assessed the influence of CA (15, 30, and 60 mg/kg, p.o.) on locomotor and exploratory behaviors via rotarod and open field tests in
Renaly I. de A. Rêgo, Hugo F. O. Pires, Arthur L. Dias, Maria Caroline R. B. Remigio, Humberto H. N. de Andrade, Pablo R. da Silva, Natália F. de Sousa, Luciana Scotti, Marcus T. Scotti, Mirian G. S. S. Salvadori, Ricardo D. de Castro   +10 more
wiley   +1 more source