Results 141 to 150 of about 62,748 (289)

Combination Pharmacotherapies for Obesity—Current Evidence and Future Directions

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
Combination pharmacotherapy for obesity can enhance weight loss by targeting complementary neuroendocrine and metabolic pathways. Such benefits are largely additive but limited by tolerability, cost and access. This review outlines practical clinical archetypes and a research agenda for safer, more precise and durable combination strategies across ...
A. B. M. Kamrul‐Hasan, Arnav Kalra, Nitin Kapoor, Deep Dutta, Kunal Mahajan, Robin Maskey, Syed Abbas Raza   +6 more
wiley   +1 more source

Catecholaminergic Contributions to Inhibitory Control Following Physical Fatigue: Behavioral and Neurophysiological Findings

European Journal of Sport Science, Volume 26, Issue 9, September 2026.
ABSTRACT Acute physical fatigue can impair cognitive control, yet its underlying neurochemical mechanisms remain unclear. This study investigated whether catecholaminergic modulation influences behavioral and neural markers of inhibitory control following physical fatigue.
Y. Laurisa Arenales Arauz, Nina Omejc, Maria Alejandra Diaz, Jelle Habay, Bram Vanderborght, Kevin De Pauw, Bart Roelands, Uros Marusic   +7 more
wiley   +1 more source

Female Mice Show Stronger Time-of-Day Modulation of Astrocytic Ca²⁺ Activity in the Sleep-Regulatory Ventrolateral Preoptic Nucleus. [PDF]

Glia
VLPO astrocytes exhibit sex‐specific Ca2+ dynamics across the nycthemeral cycle. Males show faster Ca2+ kinetics, while females display increased amplitude, frequency, and network coupling at Zeitgeber Time (ZT)‐14. Sex is a key variable in astrocyte‐based sleep regulation mechanisms.
Bellier FC, Zonca L, Holcman D, Chauveau F, Rouach N, Rancillac A.   +5 more
europepmc   +2 more sources

Icariside II in Neurological Disorders: Mechanistic Insights Into Alzheimer's Disease, Cerebral Ischemia and Parkinson's Disease

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
The graphical abstract represents the underlying neuroprotective potential of ICS II against Alzheimer's disease, Cerebral ischemia and Parkinson disease. ICS II downregulates ROS production, inflammation, mitochondrial dysfunction and apoptosis along with regulating their key signalling pathways.
Ashutosh Solanki, Khushi Sharma, Jagrati Jain, Niraj Kumar Singh, Praveen T. Krishnamurthy   +4 more
wiley   +1 more source

The Noradrenergic Brain in Parkinson's Disease. [PDF]

Curr Neurol Neurosci Rep
Pasquini J, Palermo G, Pavese N, Ceravolo R.   +3 more
europepmc   +1 more source

Development and Clinical Utility of Machine Learning Models for Prediction of Same‐Day Discharge in Outpatient Hip and Knee Replacement: A Prognostic Study

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 8, September 2026.
ABSTRACT Background Hip and knee replacement are common procedures with an increasing focus on same‐day surgery. However, capacity constraints limit the number of eligible patients actually being scheduled for same‐day discharge, calling for further selection of those with the highest likelihood of same‐day discharge.
Christoffer C. Jørgensen, Jakob B. Frederiksen, Henrik Kehlet, Martin Lindberg‐Larsen, Kirill Gromov, Claus Varnum, Thomas Jakobsen, Manuel Josef Bieder, Mikkel Rathsach Andersen, Søren Overgaard, Torben B. Hansen, Troels Petersen   +11 more
wiley   +1 more source

Neurotransmitter Systems Underlying Freezing of Gait (FOG) in Parkinson's Disease. [PDF]

Eur J Neurosci
Cho M, Cho JW, Yoo D, Park J, Kwon DY, Koh SB, Park JH, Youn J.   +7 more
europepmc   +1 more source

Candidate Right Locus Coeruleus‐Centered Symptom Pathways in Young Major Depressive Disorder: A Multimodal Magnetic Resonance Imaging Study

Human Brain Mapping, Volume 47, Issue 12, August 15, 2026.
In young major depressive disorder, substantia nigra and locus coeruleus qMRI phenotypes were linked to functional network organization and depressive severity through right locus coeruleus‐centered connectivity pathways. ABSTRACT Major depressive disorder (MDD) involves network‐level abnormalities that may reflect dysfunction in catecholaminergic ...
Zesong Yuan, Jing Wang, Danian Li, Baohua Cheng, Yingpeng Kuang, Rongyu Zhang, Nana Luo, Shijun Qiu, Yongsheng Chen, Yujie Liu   +9 more
wiley   +1 more source

Mechanisms of upper airway muscle control in sleep reveal therapeutic targets for obstructive sleep apnea. [PDF]

Am J Respir Cell Mol Biol
Horner RL, Wellman DA, Sands SA, Azarbarzin A, Taranto-Montemurro L.   +4 more
europepmc   +1 more source

Miniaturized Bidirectional Thermal Stimulation System Integrated With an Electrode Array for Recording Neural Activities

Advanced Science, Volume 13, Issue 44, 7 August 2026.
This study presents a miniaturized bidirectional thermal stimulation system integrated with an electrode array enabling real‐time, bidirectional modulation and simultaneous recording of neural activity through localized heating and cooling. By monolithic integration of the Peltier element and with a silicon neural probe, the innovative system allows ...
Zoia Naumkina, Kanghwan Kim, Wesley Charles Smith, Keuntae Kim, Shinwoo Lee, Jiwan Woo, Il‐Joo Cho   +6 more
wiley   +1 more source