Results 151 to 160 of about 10,132 (232)

Anti‐Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea

Chronic Diseases and Translational Medicine, Volume 12, Issue 2, Page 100-112, June 2026.
Cellular and molecular mechanisms of obesity‐related obstructive sleep apnea (OSA). ADMA: asymmetric dimethyrarginine, NLRP3: nucleotide‐binding domain, leucine‐rich repeat family, Pyrin domain containing 3, TLR: toll‐like receptors, IL‐1β: interleukin‐1β, IL‐6: interleukin‐6; LPS: lipopolysacharide, ROS: reactive oxygen species, TNF‐α.
Anish Preshy, Cornelius J. Fernandez, Mohammad Hamid Nedai, Joseph M. Pappachan   +3 more
wiley   +1 more source

In Situ Hybridization Chain Reaction and Immunohistochemical Labeling of the Octopamine Production Pathway in the Central Nervous System of Lymnaea stagnalis

Journal of Comparative Neurology, Volume 534, Issue 6, June 2026.
Octopaminergic neurons in the central nervous system of Lymnaea stagnalis were mapped using three complementary markers: mRNA, enzyme, and neurotransmitter. While substantial overlap was observed, discrepancies revealed neuroanatomical complexities, reinforcing the value of combining HCR and IHC for a more robust interpretation of neurotransmitter ...
Victoria Tweedie‐Pitre, Yulia Reunova, Russell C. Wyeth   +2 more
wiley   +1 more source

Comparative functions of the central noradrenergic, dopaminergic and cholinergic systems

, 1987
Comparative functions of the central noradrenergic, dopaminergic and cholinergic ...
T ROBBINS (18244786)
core  

Progress of Immunotherapies in Parkinson's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Parkinson's disease (PD) is caused by an immune disorder triggered by α‐synuclein, leading to a persistent neuroinflammatory cycle that drives the disease from non‐motor symptoms to the motor stage. Second, it presents active and passive immunotherapy strategies targeting α‐synuclein and their potential in slowing down the disease progression.
Yong Peng, Xu‐hui Kang, Shun‐yu Yao, Xiuli Zhang, Sugimoto Kazuo, Jia Liu, Miao‐qiao Du, Lan‐xin Lin, Dai‐yi Jiang, Quan Chen, Hong Jin   +10 more
wiley   +1 more source

Integrating Pharmacovigilance Data Mining and Mendelian Randomization to Identify Risk Profiles and Causal Targets of Opioid‐Induced Delirium

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Opioids like methadone and oxycodone pose a high risk for delirium, particularly in older adults and females. By integrating pharmacovigilance data and Mendelian randomization, we identify key genes (COMT, MYD88, CYP1B1) that influence delirium risk.
Xuetai Chen, Yuting Liu, Mingxuan Zhu, Xingman Chen, Fengyun Liu, Jiahao Jin, Zhiguo Jiang, Bin Qian, Feng Li   +8 more
wiley   +1 more source

Exercise Intervention for REM Sleep Behavior Disorder in Parkinson's Disease: Mechanisms and Implications for Neurorehabilitation

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This review systematically explores exercise as a multi‐target intervention for RBD, highlighting its mechanisms of action and regulatory effects on key pathophysiological processes. ABSTRACT Backgrounds REM sleep behavior disorder (RBD) is a prodromal non‐motor symptom of Parkinson's disease (PD) and other α‐synucleinopathies, affecting approximately ...
Xinhui Qiu, Zihui Wang, Ruixue Xu, Yiying Hu, Weidong Le   +4 more
wiley   +1 more source

Ocular Adverse Events Associated With Antidepressants: A Large‐Scale Data Analysis From the FAERS Database

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This decadal FAERS study (2015–2024) identifies 62,020 ocular adverse events (AEs) across 39 antidepressants, highlighting ocular neuromuscular disorders as a key risk. NDDIs show the strongest associations, while SSRIs exhibit the broadest signal spectrum.
Yiming Peng, Yichen Cao, Hanhan Liu, Junlong Ma, Guoping Yang   +4 more
wiley   +1 more source

Investigation of brainstem noradrenergic pathways that modulate nociception.

, 1996
Investigation of brainstem noradrenergic pathways that modulate ...
Gordon Copeland. Newsom (7966061)
core  

Evaluating Anesthetics for Improving Scientific Research and Welfare Using Larval Zebrafish

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Using physiological and behavioral assays, we quantified the effectiveness and appropriateness of six commonly used fish anesthetics on zebrafish embryos. Different anesthetics performed better under different contexts. Figure prepared using BioRender.com.
Sylvia Dimitriadou, Mhairi Miller, Ali Pilehvar, Lynne U. Sneddon, Jessica L. Bamsey, Damilola Hogan‐Bassey, Maciej Trznadel, Jonathan S. Ball, Aya Takesono, Courtney Hillman, Hannah Rickard, Grace Popplewell, Jenna Corcoran, Tetsuhiro Kudoh, Charles R. Tyler, Matthew J. Winter   +15 more
wiley   +1 more source

Unstable slow oscillations couple with epileptogenic fast‐rhythm bistability in sleep‐related epilepsy: A stereoelectroencephalographic study

Epilepsia, Volume 67, Issue 6, Page 2924-2939, June 2026.
We examined the functional relationship between large‐scale δ‐band phase synchrony and local epileptogenic β–γ‐band amplitude bistability during NREM sleep. Increased synchrony and strong bistability characterized the epileptogenic zone, with strongest effects during N2 sleep, when seizures most frequently occur.
Gaia Burlando, Chiara Belforte, Felix Siebenhühner, Luca Di Tullio, Lorenzo Chiarella, Vladislav Myrov, Frédéric Zubler, Monica Roascio, Francesco Cardinale, Satu Palva, J. Matias Palva, Laura Tassi, Lino Nobili, Gabriele Arnulfo, Sheng H. Wang   +14 more
wiley   +1 more source