Results 151 to 160 of about 62,748 (289)

Central noradrenergic deficiency in post-infectious chronic fatigue: neurobehavioral correlates. [PDF]

Brain Commun
Aregawi L, Walitt B, Sullivan P, Norato G, Benjamin RN, Goldstein DS.   +5 more
europepmc   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, Volume 13, Issue 48, 28 August 2026.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

BOLD fMRI activations and LC contrast associated with successful episodic memory in healthy older adults and MCI

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION We examined whether locus coeruleus (LC) contrast, an indirect proxy for neuronal density and structural health, was related to delayed episodic memory in healthy older adults (OAs) and those with mild cognitive impairment (MCI) and its association with encoding‐related brain activity, controlling for emotional salience.
Lucia Penalba‐Sánchez, Yeo‐Jin Yi, Elif Kurt, Grazia Daniela Femminella, Clare Loane, Millie Duckett, Alina Zhunussova, Nikolaus Weiskopf, Martina F Callaghan, Ray Dolan, Robert J Howard, Emrah Düzel, Dorothea Hämmerer   +12 more
wiley   +1 more source

Interaction between noradrenergic and cholinergic signaling in amygdala regulates anxiety- and depression-related behaviors in mice

Neuropsychopharmacology, 2018
Y. Mineur, Emma L M Cahuzac, Tenna N. Mose, Matthew Bentham, Margreet E. Plantenga, D. Thompson, M. Picciotto   +6 more
semanticscholar   +1 more source

Astrocyte reactivity modifies the effects of locus coeruleus norepinephrine‐related dysfunction on tau and its impact on cognition

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Animal models demonstrated that pharmacologically‐induced lesioning of the locus coeruleus (LC), the brain's primary source of norepinephrine, triggered astrocyte reactivity, exacerbating Alzheimer's disease (AD) pathology and cognitive deficits.
Prokopis C. Prokopiou, Maxime Van Egroo, Joost M. Riphagen, Marion Baillet, Nicholas J. Ashton, Shorena Janelidze, Reisa A. Sperling, Keith A. Johnson, Kaj Blennow, Oskar Hansson, Henrik Zetterberg, Heidi I. L. Jacobs   +11 more
wiley   +1 more source

Imbalance of Excitatory and Inhibitory Neurotransmitter Systems in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. [PDF]

Int J Mol Sci
Wirth KJ, Scheibenbogen C.
europepmc   +1 more source

Vulnerability of locus coeruleus connections to aging and Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION The locus coeruleus (LC) is important in coordinating communication between brain regions through its widespread connections. However, the organization of its connections, and its changes with aging and Alzheimer's disease (AD), remains unclear.
Blanca Zufiria‐Gerbolés, Daniel Vereb, Mite Mijalkov, Massimiliano Passaretti, Giovanni Volpe, Zhilei Xu, Thomas Hinault, Sara Garcia‐Ptacek, Joana B. Pereira, for the Alzheimer's Disease Neuroimaging Initiative   +9 more
wiley   +1 more source

Modelling cognitive outcomes in the UK Biobank: Education, noradrenaline and frontoparietal networks. [PDF]

PLoS One
Bravo-Merodio L, Olley-Williams JA, Russ D, Gkoutos G, Brosnan MB, Bellgrove MA, Chechlacz M.   +6 more
europepmc   +1 more source

Regional astrocyte dysregulation and altered glymphatic‐related markers in Alzheimer's disease frontal cortex

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Astrocyte dysfunction is central to Alzheimer's disease (AD), yet expression patterns of astrocytic markers remain poorly defined. We measured Aquaporin‐4 (AQP4) and glial fibrillary acidic protein (GFAP) in post‐mortem frontal cortex of AD patients and controls across BrainNet Europe (BNE) stages.
Harry Alexopoulos, Xanthippi P. Louka, Edoardo Rosario De Natale, Kelly Koutroubi, Lisa Cashmore, Maria T. Panayotacopoulou, Ioannis P. Trougakos, Heather Wilson, Marios Politis   +8 more
wiley   +1 more source

Roles of the Cholinergic and Adrenergic Systems in Vagus Nerve Stimulation for the Recovery of Motor Function in Patients with Stroke: Opportunities for Novel Treatments and Rehabilitation. [PDF]

Int J Mol Sci
Abdullahi A, Wong TWL, Ng SSM.
europepmc   +1 more source