Results 171 to 180 of about 62,748 (289)

Brain‐Wide Mapping and Synaptic Localization of C1QL3 Using a Novel Epitope‐Tagged Knock‐In Mouse

Journal of Comparative Neurology, Volume 534, Issue 8, August 2026.
C1QL3 is a secreted adhesion molecule that acts as a key regulator of synaptic structure and function. We generated and validated a novel epitope‐tagged knock‐in mouse line (C1ql32HA) in which two hemagglutinin (HA) epitopes were inserted near the N‐terminus of the endogenous C1QL3 protein.
William P. Armstrong IV, James M. Salvatore, Matthew J. Sticco, Keaven Caro, J. Wesley Maddox, Angie Huang, Brenna C. McAllister, Christopher B. O'Connell, Siu‐Pok Yee, Amy Lee, Susanne Ressl, David C. Martinelli, Alexander C. Jackson   +12 more
wiley   +1 more source

Synergetic effect of a DSP4-induced locus coeruleus lesion and systemic LPS exacerbates substantia nigra dopaminergic neuron loss. [PDF]

Sci Rep
Şimşek F, Papová D, Henriksson E, Olmedo-Díaz S, Blyberg M, El-Habta R, Virel A, Af Bjerkén S.   +7 more
europepmc   +1 more source

VMAT‐DAT‐Dopamine Regulatory System Involved in the Protective Effect of 3‐n‐Butylphthalide Against Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Proposed mechanism underlying NBP protection against ischemic stroke. NBP exerts neuroprotection against cerebral ischemic injury partially via upregulating the VMAT‐DAT‐dopamine cycle to improve synaptic dysfunction. Activation of D1R and adenosine A1Rs participates in the relevant downstream signalling cascades.
Xiao‐Ting Zhou, Qin Liu, Ming Chen, Ruo‐Xi Zhang, Yi‐Ling Su, Ding‐Feng Su, Ai‐Jun Liu   +6 more
wiley   +1 more source

Active Vaccination Strategies for Alzheimer's Disease: An Expanded Review

European Journal of Immunology, Volume 56, Issue 8, August 2026.
Overview of immunotherapeutic strategies targeting Alzheimer's disease (AD) pathology and their clinical implications. (Left) Key neuropathological hallmarks of AD, including extracellular amyloid‐beta (Aβ) aggregates and intraneuronal hyperphosphorylated Tau (phospho‐Tau), converge to produce synaptic failure, neuroinflammation and neuronal ...
Antonella Comitato, Antonino Neri, Andrea Cossarizza   +2 more
wiley   +1 more source

No effect of transcutaneous auricular vagus nerve stimulation on response inhibition. [PDF]

Front Hum Neurosci
Yamamoto S, Miyaguchi S, Shiga K, Yokota H, Inukai Y, Otsuru N, Onishi H.   +6 more
europepmc   +1 more source

The Link Between Exposure to Traumatic Stress and Chronic Pain: The Mediation Effect of Hyperarousal Is Moderated by Sensitivity to Pain Traumatization

European Journal of Pain, Volume 30, Issue 7, August 2026.
ABSTRACT Background Posttraumatic stress disorder (PTSD) is highly comorbid with chronic pain. Yet, the effects of PTSD's seemingly opposing characteristics—hyperarousal and dissociation—on chronic pain are unclear. This study examined a moderated mediation model, accordingly (a) traumatic stress is associated with higher risk for chronic pain, through
Noga Gur, Ruth Defrin, Yana Beitelman, Iftah Biran, Itay Goor‐Aryeh, Silviu Brill, Dorin Goldsmith, Eldad Katz, Nir Segev, Tali Ginsburg, Karni Ginzburg   +10 more
wiley   +1 more source

Selective vulnerability of monoaminergic neurons and network spread of alpha-synuclein jointly explain pathology progression in Parkinson's disease models. [PDF]

Neurobiol Dis
Teshome S, Torok J, Mezias C, Gupta A, Raj A.   +4 more
europepmc   +1 more source

A guide to neuromodulation in drug‐resistant epilepsy

Epileptic Disorders, Volume 28, Issue 4, Page 953-980, August 2026.
Abstract Neuromodulation is approved for the treatment of drug‐resistant epilepsy. It has been increasingly utilized over the past two decades with the approval of deep brain stimulation (DBS) and responsive neurostimulation (RNS) in addition to vagus nerve stimulation (VNS)—particularly in patients who are not deemed to be good resective surgical ...
Prachi Parikh, Irena Dolezawa, Manu Hegde, Lukas Imbach, Brian N. Lundstrom, Francesca Pizzo, Vikram R. Rao, Jaysingh Singh, Derek Southwell, Satsuke Watanabe, Birgit Frauscher   +10 more
wiley   +1 more source

Adrenergic receptor activation triggers stress-induced dystonia in a CACNA1A mutant mouse model. [PDF]

Front Neurosci
Bohne P, Grömmke M, Rybarski M, Nair T, Mark MD.   +4 more
europepmc   +1 more source

Neuromodulatory subcortical systems in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Alexander J. Ehrenberg, Neus Falgàs, Heidi I. L. Jacobs, Lea T. Grinberg, ISTAART NSS PIA Executive Committee Chairs, 2020–2028   +5 more
wiley   +1 more source