Results 171 to 180 of about 74,045 (223)

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai, Chongxiang Wang, Ping Jiang, Xiaopeng Mei   +3 more
wiley   +1 more source

Quantitative [¹⁸F]FDOPA PET/CT for the characterization of biochemical phenotypes in paraganglioma and pheochromocytoma. [PDF]

EJNMMI Rep
Dahlmann P, Onkes M, Kunte S, Auer MK, Disko U, Wang K, Lottspeich C, Stüfchen I, Schweizer JROL, Mansour N, Brendel M, Schmid-Tannwald C, Fischer A, Nölting S, Auernhammer CJ, Reincke M, Bidlingmaier M, Werner RA, Kroiss M, Völter F.   +19 more
europepmc   +1 more source

The Glymphatic System and Meningeal Lymphatics: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 4, April 2026.
Brain waste clearance relies on the anatomical and functional integration of the glymphatic system and meningeal lymphatic vessels. Cerebrospinal fluid influx into the brain parenchyma occurs along periarterial spaces, a process driven by polarized aquaporin‐4 (AQP4) water channels on astrocytic endfeet.
Hangzhe Sun, Haonan Fan, Yuhang Zhou, Haoliang Zhu, Yu Chen, Rui Zhang, Kankai Wang, Yuanbo Pan, Anke Zhang   +8 more
wiley   +1 more source

Neurotransmitter Dysregulation in Parkinson's Disease: Pathophysiological Insights and Therapeutic Perspectives. [PDF]

ACS Chem Neurosci
Aslan FS, Barut B, Ozturk S, Eyigurbuz T, Akyuz E.   +4 more
europepmc   +1 more source

Monoaminergic Networks of Cognitive and Behavioral Symptoms in Early Parkinson's Disease

Movement Disorders, Volume 41, Issue 4, Page 1004-1015, April 2026.
Abstract Background Parkinson's disease (PD) is associated with several behavioral and cognitive symptoms, the neurobiological background of which is not yet fully understood. Objectives The aim was to investigate the association between monoamine function and four specific nonmotor symptoms in early PD using the Parkinson's Progression Markers ...
Kalle J. Niemi, Valtteri Kaasinen, Rimona S. Weil, Juho Joutsa   +3 more
wiley   +1 more source

What is new in Freezing of Gait? [PDF]

J Neurol
Gülke E, Lewis SJG.
europepmc   +1 more source

OSA Endotyping as Targets for Treatment. How Far Have We Come?

Respirology, Volume 31, Issue 4, Page 339-351, April 2026.
ABSTRACT Obstructive sleep apnoea (OSA) is highly prevalent and is associated with significant impairments in quality of life and comorbidity. The most common treatment employed is continuous positive airway pressure (CPAP), especially in moderate and severe cases.
Walter T. McNicholas, Sara Op de Beeck, Pasquale Tondo, Johan Verbraecken, Maria R. Bonsignore   +4 more
wiley   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Beyond neurons: astrocytic ensembles stabilize memories after recall. [PDF]

Signal Transduct Target Ther
Bakr M, Salama M.
europepmc   +1 more source

Alpha‐2‐adrenoreceptor agonists as analgesic drugs in equine medicine

Equine Veterinary Education, Volume 38, Issue 4, Page 220-228, April 2026.
Summary Managing pain in horses is challenging despite the availability of nonsteroidal anti‐inflammatory drugs, local anaesthetics, opioids and α2‐adrenoreceptor agonists. While α2‐agonists are widely used for sedation and restraint, their analgesic properties remain underutilised.
J. A. E. Hubbell, J. Brandly, W. W. Muir III, J. Page, K. Hopster   +4 more
wiley   +1 more source