Results 181 to 190 of about 74,045 (223)

Postprandial Hypotension—Methods for the Evaluation and Management

Geriatrics &Gerontology International, Volume 26, Issue 4, April 2026.
Postprandial hypotension (PPH) is highly prevalent in older patients; however, its diagnosis remains challenging due to the absence of a consensus guideline for diagnostic criteria. Lifestyle modification is the first‐line management, taking into account the pathophysiology underlying PPH and the coexisting conditions of orthostatic hypotension and ...
Joji Ishikawa, Ayumi Toba, Shutaro Futami, Kazumasa Harada   +3 more
wiley   +1 more source

Activation of a locus coeruleus to ventral tegmental area noradrenergic pathway blunts binge-like ethanol intake and promotes aversive unconditioned responses in TH-ires-Cre mice. [PDF]

Neuropharmacology
Drinkuth CR, Dornellas APS, Navarro M, Thiele TE.   +3 more
europepmc   +1 more source

A Novel Mouse Model of Sympathoadrenal Catecholamine Deficiency by Ablation of the Tyrosine Hydroxylase Gene With Slc6a4‐Cre

Journal of Neurochemistry, Volume 170, Issue 4, April 2026.
Tyrosine hydroxylase (TH) is a rate‐limiting enzyme for catecholamine synthesis. In this study, we generated a novel Th gene conditional knockout mouse line by crossing Th‐flox mice with Slc6a4‐Cre mice. To our surprise, TH expression was largely lost in the adrenal medulla and sympathetic neurons in the conditional knockout mice.
Ryohei Ogawa, Ryo Fukumoto, Satoshi Hara, Nobuhiro Hayashi, Hiroshi Ichinose   +4 more
wiley   +1 more source

Efficacy and Spinal Noradrenergic Mechanisms of Contralateral Melittin Acupuncture Against Paclitaxel-Induced Peripheral Neuropathic Pain in Rats. [PDF]

J Pain Res
Li D, Xue F, Wu Y, Chang L, Song Y, Du X, Wu J, Liu Q, Wang T.   +8 more
europepmc   +1 more source

Frequency‐Dependent Effects of Transauricular Vagus Nerve Stimulation on Alleviating Visceral Hypersensitivity: Involvement of the Nesfatin‐1/CRF/CRF1R Pathway

Neurogastroenterology &Motility, Volume 38, Issue 4, April 2026.
taVNS alleviates visceral hypersensitivity in a frequency‐dependent manner (2 Hz most effective), potentially via the hypothalamic nesfatin‐1/CRF/CRF1R pathway. ABSTRACT Background Visceral hypersensitivity (VH) is acknowledged as a critical pathogenic mechanism underlying functional gastrointestinal disorders (FGIDs), which is influenced by ...
Wanli Xu, Ziqin Zhou, Shuai Zhou, Ruirui Zhao, Weijian Zhu, Huan Chen, Jingzhu Zhou, Zhaohui Zhang   +7 more
wiley   +1 more source

Electroacupuncture alleviates cognitive impairments in APP/PS1 mice via gastric vagal afferent-mediated activation of the nucleus tractus solitarius‒locus coeruleus noradrenergic circuit. [PDF]

Chin Med
Yu C, Li M, Shen F, Gao S, Wang J, He C, Wang L, Wu Y, Du Y.   +8 more
europepmc   +1 more source

Noradrenergic regulation of skeletal muscle oxygen pressures: Impact of heart failure with preserved ejection fraction and heat therapy

Experimental Physiology, Volume 111, Issue 4, Page 1875-1890, 1 April 2026.
Abstract Attenuation of sympathetic vasoconstriction during exercise (functional sympatholysis) contributes to skeletal muscle oxygen delivery–utilization matching. However, the extent to which muscle contractions impact noradrenergic regulation of interstitial oxygen pressures (PO2is${P_{{{\mathrm{O}}_2}}}_{{\mathrm{is}}}$; the driving force for blood–
Edward T. N. Calvo, Jacob M. Pontorno, Benjamin Zeidler, Taciane M. M. Pejon, Michael D. Belbis, Scott K. Ferguson, Craig J. Goergen, Timothy P. Gavin, Bruno T. Roseguini, Igor A. Fernandes, Daniel M. Hirai   +10 more
wiley   +1 more source

Locus Coeruleus MR Measured Signal Intensity in Fibromyalgia Relative to Healthy Controls. [PDF]

Eur J Pain
DeMayo MM, Cassidy CM, McCreary C, Trang T, Harris AD, McGirr A.   +5 more
europepmc   +1 more source

Isometric handgrip contraction increases tibialis anterior intrinsic motoneuron excitability in a dose‐dependent manner

Experimental Physiology, Volume 111, Issue 4, Page 2200-2213, 1 April 2026.
Abstract The contribution of persistent inward currents (PICs) to motoneuron firing in the lower limb typically increases after a remote handgrip contraction, believed to result from diffuse serotonergic input increases in spinal cord. We investigated whether handgrip contraction intensity, duration and/or impulse would affect PIC estimates in tibialis
Lucas Ugliara, Lucas B. R. Orssatto, Amilton Vieira, Gabriel S. Trajano   +3 more
wiley   +1 more source

Possible Role of Dopamine in the Enhancement of Intrahippocampal Arc Protein Expression Induced by Post-Learning Noradrenergic Stimulation of the Basolateral Amygdala. [PDF]

Int J Mol Sci
Peshev B, Atanasova D, Rashev P, Kortenska L, Mourdjeva M, Pupaki D, Efstratiou N, Dimitrov N, Tchekalarova J.   +8 more
europepmc   +1 more source