Dreaming of Better Treatments: Advances in Drug Development for Sleep Medicine and Chronotherapy
Journal of Sleep Research, EarlyView.ABSTRACT Throughout history, the development of new sleep medicines has been driven by progress in our understanding of the mechanisms underlying sleep. Ancient civilisations used their understanding of the sedative nature of natural herbs and compounds to induce sleep.
Brooke A. Prakash +5 more
wiley +1 more source
Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression. [PDF]
, 2011 Several studies have proposed that brain glutamate signaling abnormalities and glial pathology have a role in the etiology of major depressive disorder (MDD).
Akil, H +9 more
core
Present and Future of Central Disorders of Hypersomnolence
Journal of Sleep Research, EarlyView.ABSTRACT Central disorders of hypersomnolence (CDH) are rare neurological conditions lumped by excessive daytime sleepiness (EDS) as primary complaint mostly arising at young age, including narcolepsy type 1 (NT1), narcolepsy type 2 (NT2), idiopathic hypersomnia (IH), and Kleine‐Levin syndrome (KLS). Advances in clinical and translational research have
Francesco Biscarini +4 more
wiley +1 more source
Journal of Sleep Research, EarlyView.ABSTRACT Cannabinoids, particularly Δ9‐tetrahydrocannabinol (THC) and cannabidiol (CBD), have gained popularity as alternative sleep aids; however, their effects on sleep architecture and next‐day function remain poorly understood. Here, in a pilot trial, we examined the effects of a single oral dose containing 10 mg THC and 200 mg CBD (THC/CBD) on ...
Anastasia Suraev +17 more
wiley +1 more source
Enteric neuropathy and the vagus nerve: Therapeutic implications
Neurogastroenterology &Motility, EarlyView.Abstract Enteric neuropathies are characterized by abnormalities of gut innervation, which includes the enteric nervous system, inducing severe gut dysmotility among other dysfunctions. Most of the gastrointestinal tract is innervated by the vagus nerve, the efferent branches of which have close interconnections with the enteric nervous system and ...
Bruno Bonaz
wiley +1 more source
In Search of the Neurobiological Substrates for Social Playfulness in Mammalian Brains
, 2011 Play behavior is a fundamental and intrinsic neurobehavioral process in the mammalian brain. Using rough-and-tumble play in the juvenile rat as a model system to study mammalian playfulness, some of the relevant neurobiological substrates for this ...
Panksepp, Jaak, Siviy, Stephen M.
core +1 more source
Participation of Central Noradrenergic Neurons in Arterial Baroreceptor Reflexes in the Rabbit [PDF]
, 1971 John Chalmers, R. J. Wurtman
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The therapeutic role of exercise training during menopause for reducing vascular disease
Experimental Physiology, EarlyView.Abstract Menopause marks a major milestone in female reproductive ageing. It is characterized by the cessation of ovarian function and a concomitant decline in hormones such as oestradiol. Subsequently, females undergoing menopausal transition experience a progressive increase in cardiovascular and cerebrovascular disease risk.
Conan L. H. Shing +4 more
wiley +1 more source
MORPHINE ANALGESIA AND THE BULBOSPINAL NORADRENERGIC SYSTEM: INCREASE IN THE CONCENTRATION OF NORMETANEPHRINE IN THE SPINAL CORD OF THE RAT CAUSED BY ANALGESICS [PDF]
, 1974 Hirohito Shiomi, Hiroshi Takagi
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Impact of acute caffeine intake on local tolerance to cold before and after total sleep deprivation
Experimental Physiology, EarlyView.Abstract Total sleep deprivation (TSD) alters local cold tolerance and could thus increase the risk of cold injury. We evaluated the impact of acute caffeine intake, the main countermeasure to TSD‐related deleterious effects, on local cold tolerance before and after TSD.
Baptiste de Lorgeril +11 more
wiley +1 more source