Results 21 to 30 of about 1,089 (139)

Structure-Based Virtual Screening, Docking, ADMET, Molecular Dynamics, and MM-PBSA Calculations for the Discovery of Potential Natural SARS-CoV-2 Helicase Inhibitors from the Traditional Chinese Medicine

Journal of Chemistry, 2022
Continuing our antecedent work against COVID-19, a set of 5956 compounds of traditional Chinese medicine have been virtually screened for their potential against SARS-CoV-2 helicase (PDB ID: 5RMM).
Ahmed M. Metwaly, Alaa Elwan, Abdul-Aziz M. M. El-Attar, Sara T. Al-Rashood, Ibrahim H. Eissa   +4 more
doaj   +1 more source

Scientific Opinion on safety evaluation of Ephedra species for use in food

EFSA Journal, 2013
The ANS Panel provides a scientific opinion evaluating the safety in use of Ephedra herb and its preparations originating from Ephedra species when used in food, e.g. in food supplements.
EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)
doaj   +1 more source

(5S,6R)-5-Methyl-6-phenyl-4-propyl-1,3,4-oxadiazinane-2-thione

Acta Crystallographica Section E, 2009
The title molecule, C13H18N2OS, is an oxadiazinanthione derived from (1R,2S)-norephedrine. There are two molecules in the asymmetric. Both adopt roughly half-chair conformations; however, the 5-position carbon orients out of opposite faces of the ...
Joshua L. Kocher, Kate L. Edler, Barbara A. Bohling, George P. Nora, Carrie Stafford, Shawn R. Hitchcock, Gregory M. Ferrence   +6 more
doaj   +1 more source

Expressed sequence tag analysis of khat (Catha edulis) provides a putative molecular biochemical basis for the biosynthesis of phenylpropylamino alkaloids

Genetics and Molecular Biology, 2011
Khat (Catha edulis Forsk.) is a flowering perennial shrub cultivated for its neurostimulant properties resulting mainly from the occurrence of (S)-cathinone in young leaves.
Jillian M. Hagel, Raz Krizevski, Korey Kilpatrick, Yaron Sitrit, Frédéric Marsolais, Efraim Lewinsohn, Peter J. Facchini   +6 more
doaj   +1 more source

Process optimization for biosynthesis of pyruvate decarboxylase (PDC) and Neuberg’s ketol (PAC) from a novel Pichia cecembensis through response surface methodology

Annals of Microbiology, 2022
Purpose Phenylacetylcarbinol (PAC) is an intermediate for the synthesis of several active pharmaceutical ingredients (ephedrine, pseudoephedrine, norephedrine, etc.) used for the production of antiasthematics and decongestants.
Zareena Mushtaq, Hamid Mukhtar
doaj   +1 more source

Preparative HPLC for large scale isolation, and salting-out assisted liquid–liquid extraction based method for HPLC–DAD determination of khat (Catha edulis Forsk) alkaloids

Chemistry Central Journal, 2017
Background Khat (Catha edulis Forsk) is an evergreen shrub of the Celastraceae family. It is widely cultivated in Yemen and East Africa, where its fresh leaves are habitually chewed for their momentary pleasures and stimulation as amphetamine-like ...
Minaleshewa Atlabachew, Bhagwan Singh Chandravanshi, Mesfin Redi-Abshiro   +2 more
doaj   +1 more source

Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine [PDF]

, 2013
Background: Amphetamine and amphetamine derivatives are suggested to induce an immunosuppressive effect. However, knowledge of how amphetamines modulate intracellular signaling pathways in cells of the immune system is limited.
Anne Christine Johannessen, Aarstad, Hans Jørgen, Sulen, André, Johannessen, Anne Christine, Gjertsen, Bjørn Tore, Hans Jørgen Aarstad, Reikvam, Håkon, Erikstein, Bjarte Skoe, Øystein Bruserud, Håkon Reikvam, Bredholt, Therese, Ersvær, Elisabeth, Bjørn Tore Gjertsen, Vintermyr, Olav Karsten, Olav Karsten Vintermyr, André Sulen, Bjarte Skoe Erikstein, Bruserud, Øystein, Therese Bredholt, Elisabeth Ersvær   +19 more
core   +2 more sources

Commentary on: Attafi IM, Albeishy MY, Oraiby ME, Khardali IA, Shaikhain GA, Fageeh MM. Postmortem Distribution of Cathinone and Cathine in Human Biological Specimens in a Case of Death Associated wit

Arab Journal of Forensic Sciences & Forensic Medicine, 2019
The interpretation of post-mortem human tissue toxicology levels may be affected by the sampling site chosen. It is important to bear this in mind when looking at the psychoactive constituents of khat (Catha edulis Forsk) that have been consumed and have
John M. Corkery, Fabrizio Schifano, Amira Guirguis   +2 more
doaj   +1 more source

Microwave-Assisted Improved Synthesis of Oxazolidin-2-ones, Oxazolidine-2-thiones and Thiazolidine-2-thione Chiral Auxiliaries

Molecules, 2011
A microwave assisted method for the synthesis of some typical 4-substituted oxazolidinone chiral auxiliaries used in asymmetric synthesis is reported in this work.
Mario Ordóñez, Rosmarbel Morales-Nava, Mario Fernández-Zertuche   +2 more
doaj   +1 more source

Cation-exchange solid-phase and liquid-liquid extraction for the determination of khat alkaloids by reversed phase HPLC-DAD

Bulletin of the Chemical Society of Ethiopia, 2015
Leaves of khat (Catha edulis) are masticated to elicit their psycho-stimulating properties, resulting from the presence of the phenylpropylamino alkaloids.
M. Atlabachew, S. Combrinck, R. I. McCrindle   +2 more
doaj   +1 more source