Results 1 to 10 of about 1,089 (139)

Observation of Hyperpositive Non-Linear Effect in Asymmetric Organozinc Alkylation in Presence of N-Pyrrolidinyl Norephedrine. [PDF]

Molecules, 2022
Phenomena related to asymmetric amplification are considered to be key to understanding the emergence of homochirality in life. In asymmetric catalysis, theoretical and experimental models have been studied to understand such chiral amplification, in ...
Thierry T, Geiger Y, Bellemin-Laponnaz S.   +2 more
europepmc   +5 more sources

Correction: Thierry et al. Observation of Hyperpositive Non-Linear Effect in Asymmetric Organozinc Alkylation in Presence of N-Pyrrolidinyl Norephedrine. Molecules 2022, 27, 3780. [PDF]

Molecules
The authors wish to make the following correction to their paper [...]
Thierry T, Geiger Y, Bellemin-Laponnaz S.   +2 more
europepmc   +4 more sources

Enantioselective Quantification of Amphetamine and Metabolites in Serum Samples: Forensic Evaluation and Estimation of Consumption Time. [PDF]

Metabolites, 2021
In forensic toxicology, amphetamine intoxications represent one of the most common case groups and present difficult questions for toxicologists. Estimating the time of consumption and the current influence of the stimulant is particularly difficult when
Losacker M, Kraemer M, Philipsen A, Duecker K, Dreimueller N, Engelmann J, Roehrich J, Hess C.   +7 more
europepmc   +2 more sources

Cardiac effects of ephedrine, norephedrine, mescaline, and 3,4-methylenedioxymethamphetamine (MDMA) in mouse and human atrial preparations [PDF]

Naunyn-Schmiedeberg's Archives of Pharmacology, 2022
The use of recreational drugs like ephedrine, norephedrine, 3,4-methylenedioxymethamphetamine (MDMA), and mescaline can lead to intoxication and, at worst, to death.
Joachim Neumann, Ulrich Gergs, Britt Hofmann   +2 more
exaly   +2 more sources

In vitro and in vivo metabolism profiles of cathinone and pseudoephedrine: Discrimination between khat and pseudoephedrine uses. [PDF]

J Forensic Sci
Abstract In the present study, the metabolism of khat (Catha edulis) and pseudoephedrine was compared with the aim of identifying objective criteria that could be used to discriminate between them for forensic and doping‐control purposes. An in vitro study using human liver microsomes and an in vivo study using rat urine were performed under harmonized
Park JS, Yu JS, Kim Y, Kim HS, Cheong JC, Kim JY, Yoo HH.   +6 more
europepmc   +2 more sources

Analytical Challenges in Detecting New Psychoactive Substances in Anti-Doping: A Proof-of-Concept Involving Pentedrone Metabolite. [PDF]

Drug Test Anal
The paper describes an investigation related to the pentedrone norephedrine metabolite. The athlete's sample was analyzed using ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS). According to the literature, this metabolite may originate from pentedrone, α‐pyrrolidinopentiophenone (PVP), or N‐ethylpentedrone (NEP).
Kwiatkowska D, Peta B, Grucza K, Łabęcka A, Konarski P, Wojtkowiak K, Grela K, Sytniczuk A, Wicka M.   +8 more
europepmc   +2 more sources

Khat, a Cultural Chewing Drug: A Toxicokinetic and Toxicodynamic Summary. [PDF]

Toxins (Basel), 2022
Khat (Catha edulis) is a recreational, chewed herbal drug that has been used as a psychostimulant for centuries in East Africa and the Arabian Peninsula, namely in Somalia, Ethiopia, and Yemen.
Silva B, Soares J, Rocha-Pereira C, Mladěnka P, Remião F, On Behalf Of The Oemonom Researchers.   +5 more
europepmc   +2 more sources

Methamphetamine Enantiomers: From Chemical Synthesis to Biological Fate. [PDF]

Chirality
Methamphetamine is an amphetamine‐type stimulant characterized by a single stereogenic center, resulting in two enantiomers, (R)‐(−)‐methamphetamine and (S)‐(+)‐methamphetamine, with distinct biological and pharmacological profiles. These forms exhibit differences in central nervous system activity, metabolism, excretion, and overall physiological ...
do Espírito Santo LP, de Carvalho RL, Sad JA, Dos Santos PHC, Domingues RS, de Azevedo Cardoso G, Enes KB, Goulart GAC, de Castro Lourenço das Neves M, de Fátima Â.   +9 more
europepmc   +2 more sources

Synthesis of some quinazolinones inspired from the natural alkaloid L-norephedrine as EGFR inhibitors and radiosensitizers. [PDF]

J Enzyme Inhib Med Chem, 2021
A set of quinazolinones synthesized by the aid of L-norephedrine was assembled to generate novel analogues as potential anticancer and radiosensitizing agents.
Ghorab MM, Abdel-Kader MS, Alqahtani AS, Soliman AM.   +3 more
europepmc   +2 more sources

Yangke powder alleviates OVA-induced allergic asthma by inhibiting the PI3K/AKT/NF-κB signaling pathway. [PDF]

Chin Med
Background Asthma is a chronic inflammatory airway disease that remains inadequately controlled by existing conventional treatments. A traditional Chinese medicine (TCM) formula of Yangke powder (yǎng ké sǎn-YKS) has demonstrated potential in alleviating
Li X, Ding L, Li Z, Cao Z, Li M, Yin K, Song S, Cao L, Xia Q, Wang Z, Zhao D, Tong X, Li X, Wang Z.   +13 more
europepmc   +2 more sources