Results 11 to 20 of about 2,134 (194)

Analytical Challenges in Detecting New Psychoactive Substances in Anti-Doping: A Proof-of-Concept Involving Pentedrone Metabolite. [PDF]

Drug Test Anal
The paper describes an investigation related to the pentedrone norephedrine metabolite. The athlete's sample was analyzed using ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS). According to the literature, this metabolite may originate from pentedrone, α‐pyrrolidinopentiophenone (PVP), or N‐ethylpentedrone (NEP).
Kwiatkowska D, Peta B, Grucza K, Łabęcka A, Konarski P, Wojtkowiak K, Grela K, Sytniczuk A, Wicka M.   +8 more
europepmc   +2 more sources

Biosynthesis of Ephedrine Initiated by Pyridoxal Phosphate-Dependent Formation of Cathinone. [PDF]

Chembiochem
An alternative pathway to ephedra alkaloids via (S)–cathinone is investigated in plants. This pathway circumvents the formation of 1‐phenylpropane‐1,2‐dione as an intermediate, which has been part of the predominantly postulated biosynthetic pathway for the last decades. This alternative pathway involves an enzymatic pyridoxal phosphate (PLP)‐dependent
Witte K, Behrens A, Schwelm HM, Auwärter V, Müller M.   +4 more
europepmc   +2 more sources

Multidimensional Evaluation of Lisdexamfetamine: Pharmacology, Therapeutic Use, Toxicity and Forensic Implications. [PDF]

Basic Clin Pharmacol Toxicol
Structure of lisdexamfetamine dimesylate, its active metabolite d‐amphetamine and the essential amino acid l‐lysine, along with the mechanism of action and primary pharmacological and adverse effects associated with lisdexamfetamine dimesylate. TAAR1, trace amine‐associated receptor; VMAT, vesicular monoamine transporter; DAT, dopamine transporter; NAT,
Silva-Carvalho M, Barbosa DJ, Dias da Silva D, Dinis-Oliveira RJ.   +3 more
europepmc   +2 more sources

An Integrated Engineering Approach to Intensify the Biocatalytic Metaraminol Synthesis. [PDF]

ChemSusChem
The amine transaminase‐catalyzed amination of (R)‐3‐hydroxyphenylacetylcarbinol toward metaraminol involves severe side‐product formation, hampering high product titers. The application of a continuous extraction system together with an increased amine transaminase concentration and optimal enzyme formulation enhanced the overall metaraminol yield ...
Rothkranz B, Klos N, Graf von Westarp W, Hahn D, Classen T, Grabowski L, Gentile R, Kaiser J, Schott-Verdugo S, Gohlke H, Jupke A, Rother D.   +11 more
europepmc   +2 more sources

Combination of a UPO-Based Epoxidation With a Subsequent Ring-Opening Reaction for the Synthesis of Amino Alcohols. [PDF]

Chembiochem
The synthesis of aromatic amino alcohols via a combination of an unspecific peroxygenase‐catalysed reaction, oxyfunctionalization, and addition of selected nucleophiles and electrophiles in a highly atom‐efficient manner was investigated. This study presents the design to aim for an atom‐efficient chemo‐enzymatic synthesis route towards aromatic amino ...
Last S, Dietz N, Weissenborn MJ, von Langermann J.   +3 more
europepmc   +2 more sources

AkrinorTM, a Cafedrine/ Theodrenaline Mixture (20:1), Increases Force of Contraction of Human Atrial Myocardium But Does Not Constrict Internal Mammary Artery In Vitro

Frontiers in Pharmacology, 2017
Background: Intraoperative hypotension is a common problem and direct or indirect sympathomimetic drugs are frequently needed to stabilize blood pressure.
Benjamin Kloth, Benjamin Kloth, Simon Pecha, Simon Pecha, Eileen Moritz, Yvonne Schneeberger, Yvonne Schneeberger, Klaus-Dieter Söhren, Edzard Schwedhelm, Hermann Reichenspurner, Thomas Eschenhagen, Rainer H. Böger, Torsten Christ, Sebastian N. Stehr   +13 more
doaj   +1 more source

Biocatalysis as Useful Tool in Asymmetric Synthesis: An Assessment of Recently Granted Patents (2014–2019) [PDF]

, 2019
The broad interdisciplinary nature of biocatalysis fosters innovation, as different technical fields are interconnected and synergized. A way to depict that innovation is by conducting a survey on patent activities.
Alcántara, Andrés R., Domínguez de María, Pablo, Gonzalo Calvo, Gonzalo de   +2 more
core   +3 more sources

Quality by design‐guided development of a capillary electrophoresis method for the simultaneous chiral purity determination and impurity profiling of tamsulosin

Journal of Separation Science, Volume 46, Issue 24, December 2023., 2023
Analytical Quality by Design principles using the design of experiments were applied for the development of a capillary electrophoresis method for the determination of enantiomeric purity and chemically related impurities of tamsulosin. From initial scouting experiments, a dual cyclodextrin (CD) system composed of sulfated β‐CD and carboxymethyl‐α‐CD ...
Adriana Modroiu, Sulaiman Krait, Gabriel Hancu, Gerhard K. E. Scriba   +3 more
wiley   +1 more source

Evaluation of the effect of various drying techniques on the composition of the psychoactive phenylpropylamino alkaloids of khat (Catha edulis Forsk) chewing leaves

Bulletin of the Chemical Society of Ethiopia, 2013
The study demonstrated that by freezing or drying under different conditions, cathinone could be detected in the khat (Catha edulis Forsk) samples that have been harvested for more than four months.
S. Chigome, N. Torto, M. Redi-Abshiro, B.S. Chandravanshi, M. Atlabachew, B.O. Pule   +5 more
doaj   +1 more source

Khat chewing and associated factors among public secondary school students in Harar town, Eastern Ethiopia: a multicenter cross-sectional study

Frontiers in Psychiatry, 2023
BackgroundKhat is a huge, evergreen tree that grows at high altitudes throughout the Arabian Peninsula and in the region stretching from eastern to southern Africa.
Kabtamu Nigussie, Abraham Negash, Addisu Sertsu, Abiy Mulugeta, Aklilu Tamire, Obsan Kassa, Tilahun Abdeta, Jerman Dereje   +7 more
doaj   +1 more source