Results 11 to 20 of about 1,089 (139)

Multidimensional Evaluation of Lisdexamfetamine: Pharmacology, Therapeutic Use, Toxicity and Forensic Implications. [PDF]

Basic Clin Pharmacol Toxicol
Structure of lisdexamfetamine dimesylate, its active metabolite d‐amphetamine and the essential amino acid l‐lysine, along with the mechanism of action and primary pharmacological and adverse effects associated with lisdexamfetamine dimesylate. TAAR1, trace amine‐associated receptor; VMAT, vesicular monoamine transporter; DAT, dopamine transporter; NAT,
Silva-Carvalho M, Barbosa DJ, Dias da Silva D, Dinis-Oliveira RJ.   +3 more
europepmc   +2 more sources

Biosynthesis of Ephedrine Initiated by Pyridoxal Phosphate-Dependent Formation of Cathinone. [PDF]

Chembiochem
An alternative pathway to ephedra alkaloids via (S)–cathinone is investigated in plants. This pathway circumvents the formation of 1‐phenylpropane‐1,2‐dione as an intermediate, which has been part of the predominantly postulated biosynthetic pathway for the last decades. This alternative pathway involves an enzymatic pyridoxal phosphate (PLP)‐dependent
Witte K, Behrens A, Schwelm HM, Auwärter V, Müller M.   +4 more
europepmc   +2 more sources

An Integrated Engineering Approach to Intensify the Biocatalytic Metaraminol Synthesis. [PDF]

ChemSusChem
The amine transaminase‐catalyzed amination of (R)‐3‐hydroxyphenylacetylcarbinol toward metaraminol involves severe side‐product formation, hampering high product titers. The application of a continuous extraction system together with an increased amine transaminase concentration and optimal enzyme formulation enhanced the overall metaraminol yield ...
Rothkranz B, Klos N, Graf von Westarp W, Hahn D, Classen T, Grabowski L, Gentile R, Kaiser J, Schott-Verdugo S, Gohlke H, Jupke A, Rother D.   +11 more
europepmc   +2 more sources

A System-Level Mechanism of Anmyungambi Decoction for Obesity: A Network Pharmacological Approach

Biomolecules, 2021
Obesity is a low-grade systemic inflammatory disease involving adipocytokines. As though Anmyungambi decoction (AMGB) showed significant improvement on obesity in a clinical trial, the molecular mechanism of AMGB in obesity remains unknown. Therefore, we
Dongyeop Jang, Hayeong Jeong, Chang-Eop Kim, Jungtae Leem   +3 more
doaj   +1 more source

A Rapid and Feasible ¹H-NMR Quantification Method of Ephedrine Alkaloids in Ephedra Herbal Preparations

Molecules, 2021
A highly specific and sensitive proton nuclear magnetic resonance (1H-NMR) method has been developed for the quantification of ephedrine alkaloid derivatives in Ephedra herbal commercial prescriptions.
Hsin-Yi Hung, Shih-Min Lin, Chia-Ying Li, Sio-Hong Lam, Yu-Yi Chan, Meei-Jen Liou, Po-Chuen Shieh, Fu-An Chen, Ping-Chung Kuo, Tian-Shung Wu   +9 more
doaj   +1 more source

Production of Phenylacetylcarbinol via Biotransformation Using the Co-Culture of Candida tropicalis TISTR 5306 and Saccharomyces cerevisiae TISTR 5606 as the Biocatalyst

Journal of Fungi, 2023
Phenylacetylcarbinol (PAC) is a precursor for the synthesis of several pharmaceuticals, including ephedrine, pseudoephedrine, and norephedrine. PAC is commonly produced through biotransformation using microbial pyruvate decarboxylase (PDC) in the form of
Anbarasu Kumar, Charin Techapun, Sumeth Sommanee, Chatchadaporn Mahakuntha, Juan Feng, Su Lwin Htike, Julaluk Khemacheewakul, Kritsadaporn Porninta, Yuthana Phimolsiripol, Wen Wang, Xinshu Zhuang, Wei Qi, Kittisak Jantanasakulwong, Rojarej Nunta, Noppol Leksawasdi   +14 more
doaj   +1 more source

AkrinorTM, a Cafedrine/ Theodrenaline Mixture (20:1), Increases Force of Contraction of Human Atrial Myocardium But Does Not Constrict Internal Mammary Artery In Vitro

Frontiers in Pharmacology, 2017
Background: Intraoperative hypotension is a common problem and direct or indirect sympathomimetic drugs are frequently needed to stabilize blood pressure.
Benjamin Kloth, Benjamin Kloth, Simon Pecha, Simon Pecha, Eileen Moritz, Yvonne Schneeberger, Yvonne Schneeberger, Klaus-Dieter Söhren, Edzard Schwedhelm, Hermann Reichenspurner, Thomas Eschenhagen, Rainer H. Böger, Torsten Christ, Sebastian N. Stehr   +13 more
doaj   +1 more source

Evaluation of the effect of various drying techniques on the composition of the psychoactive phenylpropylamino alkaloids of khat (Catha edulis Forsk) chewing leaves

Bulletin of the Chemical Society of Ethiopia, 2013
The study demonstrated that by freezing or drying under different conditions, cathinone could be detected in the khat (Catha edulis Forsk) samples that have been harvested for more than four months.
S. Chigome, N. Torto, M. Redi-Abshiro, B.S. Chandravanshi, M. Atlabachew, B.O. Pule   +5 more
doaj   +1 more source

Khat chewing and associated factors among public secondary school students in Harar town, Eastern Ethiopia: a multicenter cross-sectional study

Frontiers in Psychiatry, 2023
BackgroundKhat is a huge, evergreen tree that grows at high altitudes throughout the Arabian Peninsula and in the region stretching from eastern to southern Africa.
Kabtamu Nigussie, Abraham Negash, Addisu Sertsu, Abiy Mulugeta, Aklilu Tamire, Obsan Kassa, Tilahun Abdeta, Jerman Dereje   +7 more
doaj   +1 more source

(5R,6S)-4-Isopropyl-5-methyl-6-phenyl-3-propanoyl-2H-1,3,4-oxadiazinan-2-one

Acta Crystallographica Section E, 2009
The title compound, C16H22N2O3, was synthesized during the course of a study on (1R,2S)-norephedrine-derived 1,3,4-oxadiazinan-2-ones. The conformation adopted by the isopropyl group is pseudo-axial relative to the oxadiazinan core.
Dishant Tailor, Kate L. Edler, David M. Casper, Shawn R. Hitchcock, Gregory M. Ferrence   +4 more
doaj   +1 more source