Results 61 to 70 of about 1,089 (139)

Chiral amide from (1S,2R)-(+)-norephedrine alkaloid in the enantioselective addition of diethylzinc to aryl and heteroaryl aldehydes

, 2009
Chiral amide synthesized from (1S,2R)-(+)-norephedrine and furoic acid was found to catalyze the enantioselective ethylation of aromatic and heteroaromatic aldehydes to secondary alcohols with 99.8% enantioselectivity at 0 °C without the addition of a ...
Ananthi, Nallamuthu, Velmathi, S., Vinu, Ajayan, Ariga, Katsuhiko, Vinu, A., Ananthi, N., Ariga, K., Balakrishnan, Umesh, Velmathi, Sivan, Balakrishnan, U.   +9 more
core   +1 more source

Recent Progress in the Synthesis of α‐Hydroxy Carbonyl Compounds with ThDP‐dependent Carboligases

ChemCatChem, Volume 16, Issue 15, August 12, 2024.
Building carbon connections: ThDP‐dependent carboligases are biocatalysts for the (asymmetric) synthesis of α‐hydroxy‐carbonyl compounds. In this review article we summarize recent progress on structural characterization and application of carboligases for single‐ and multi‐step reactions.
Hana Dobiašová, Valentina Jurkaš, Peter Both, Margit Winkler   +3 more
wiley   +1 more source

A General and Expeditious One-Pot Synthesis of Sulfoxides in High Optical Purity from Norephedrine-Derived Sulfamidites

, 2016
A general and simple procedure for preparing any kind of enantiomerically enriched sulfoxide starting from norephedrine-derived N-benzyloxycarbonylsulfamidite 3a is reported.
María M. Zarzuelo (3039414), M. Teresa Aranda (105982), Carlos Alemparte (291057), José L. García Ruano (2526475)   +3 more
core   +1 more source

Population kinetic/pharmacodynamic modelling of the haemodynamic effects of cafedrine/theodrenaline (Akrinor) under general anaesthesia

British Journal of Clinical Pharmacology, Volume 90, Issue 8, Page 1964-1974, August 2024.
Abstract Aims The 20:1 combination of cafedrine and theodrenaline (C/T) is widely used in Germany for the treatment of arterial hypotension. Since there is little knowledge about the impact of covariates on the effect, the aim was to develop a kinetic/pharmacodynamic covariate model describing mean arterial pressure (MAP), systolic (SBP) and diastolic ...
Christiane Dings, Thorsten Lehr, Benjamin Vojnar, Christine Gaik, Tilo Koch, Leopold H. J. Eberhart, Susanne Huljic‐Lankinen, Melanie Murst, Sascha Kreuer   +8 more
wiley   +1 more source

Baker's yeast reduction of (E)-1-phenyl-1,2-propanedione 2-(O-methyloxime). A key step for a (-)-norephedrine synthesis

, 2015
The enantioselective Baker's yeast reduction of (E)-1-phenyl-1,2 propanedione 2-(O-methyloxime) 1 afforded (-)-(R)-1-hydroxy-1-phenyl-2-propanone 2-(O-methyloxime) 2 with 97% of enantiomeric excess (ee) which was diastereoselectively reduced by LiAlH4 to
Rodrigues, JAR, Kreutz, OC, Moran, PJS
core   +1 more source

A Powerful P−N Connection: Preparative Approaches, Reactivity, and Applications of P‐Stereogenic Aminophosphines

Chemistry – A European Journal, Volume 30, Issue 18, March 25, 2024.
New catalytic possibilities in the synthesis of P‐stereogenic aminophosphine chalcogenides and boranes serve as an expansion in addition to established methods based on chiral auxiliaries. Stereoselective transformations into valuable building blocks facilitate catalyst design for use in organocatalytic and transition metal‐based applications. Here, we
Tanja Huber, Jonathan O. Bauer
wiley   +1 more source

Asymmetric Hydrogenation of Ketones Catalyzed by Ruthenium Hydride Complexes of a Beta-aminophosphine Ligand Derived from Norephedrine

, 2016
A series ruthenium complexes with the chiral P−N ligand (1R,2R)-PPh2CHPhCHMeNH2 derived from (1S,2R)-norephedrine are synthesized starting from the complexes RuHCl(PPh3)3 or RuHCl(P−P)(PPh3) (P−P= (R)-binap or (S)-binap).
Rongwei Guo (2320807), Robert H. Morris (1306158), Alan J. Lough (1306146), Datong Song (1795441)   +3 more
core   +1 more source

ASYMMETRIC-SYNTHESIS OF 3,4-CIS-SUBSTITUTED BETA-LACTAMS VIA CHIRAL NOREPHEDRINE-DERIVED OXAZOLIDINES

, 1989
A diastereo- and enantioselective approach to functionalized 3,4-cis-β-lactams 9 and 16 was developed based on the use of chiral norephedrine-derived oxazolidines.
R. VILLA, S. CARDANI, C. SCOLASTICO, C. Gennari, C.M.A. GENNARI   +4 more
core   +1 more source

ASYMMETRIC-SYNTHESIS OF FUNCTIONALIZED ALPHA-AMINO-BETA-HYDROXY ACIDS VIA CHIRAL NOREPHEDRINE-DERIVED OXAZOLIDINES

, 1988
Both anti and syn enantiomerically pure functionalized α -amino-β-hydroxy acids and derivatives were synthesized starting from norephedrine-derived oxazolidine (1).
Anna Bernardi, Lino Colombo, S. CARDANI, Silvia Cardani, I. VENTURINI, C. SCOLASTICO, Carlo Scolastico, A. BERNARDI, Cesare Gennari, Isabella Venturini, L. COLOMBO, C.M.A. GENNARI   +11 more
core   +1 more source

Enantioselective Addition of Diethylzinc to Aromatic Aldehydes Using Novel Thiophene-Based Chiral Ligands

, 2020
: Chiral norephedrine-derived β-amino alcohols with a thiophene moiety were synthesized from thiophene carbaldehydes (methyl- or ethyl-substituted) and chiral amino alcohols, such as both enantiomers of norephedrine and 2-aminopropanol.
AYDIN, ALİME EBRU
core   +1 more source