Results 51 to 60 of about 2,134 (194)
Therapeutic and toxic blood concentrations of nearly 1,000 drugs and other xenobiotics [PDF]
, 2012 Introduction: In order to assess the significance of drug levels measured in intensive care medicine, clinical and forensic toxicology, as well as for therapeutic drug monitoring, it is essential that a comprehensive collection of data is readily ...
Andresen, Hilke +3 more
core +1 more source
Chemistry – A European Journal, Volume 31, Issue 32, June 6, 2025.Fused nitrogen‐bridgehead N,O‐acetals receive specific emphasis as pivotal scaffolds due to their significant role in the bioactivity of medicinally relevant molecules. Significant approaches have been reported on their role as key synthetic building blocks/motifs in the construction of complex organic molecules and their utility as chiral auxiliaries ...
Alexis D. Kouvelas +2 more
wiley +1 more source
Tautomeric Equilibria Studies by Mass Spectrometry [PDF]
, 2008 Tautomerism in organic chemistry has been extensively studied in condensed phase by spectrometric methods, mainly by IR and NMR techniques. Mass spectrometry studies start 40 years ago but just recently it has been recognized the importance of the mass ...
Eduardo A. Castro +3 more
core +1 more source
Pharmacokinetics of cathinone, cathine and norephedrine after the chewing of khat leaves [PDF]
British Journal of Clinical Pharmacology, 2003 Aim The stimulating herbal drug khat is habitually used in East Africa and the Arabian peninsula but is also imported into other countries. The aim was to study the pharmacokinetics of its alkaloids cathinone, cathine and norephedrine.Methods Four volunteers chewed khat leaves in an amount equivalent to one‐quarter of that used in a typical khat ...
Stefan W, Toennes +4 more
openaire +2 more sources
Engineering in Life Sciences, Volume 25, Issue 2, February 2025.ABSTRACT The synthesis of enantiopure α‐hydroxy ketones, particularly R‐ and S‐phenylacetylcarbinol (PAC), represents an important process in the pharmaceutical industry, serving as a pivotal step in the production of drugs. Recently, two novel enzymes, ephedrine dehydrogenase (EDH) and pseudoephedrine dehydrogenase (PseDH), have been described.
Reynaldo Jr. Carubio +2 more
wiley +1 more source
New insight on the structural features of the cytotoxic auristatins MMAE and MMAF revealed by combined NMR spectroscopy and quantum chemical modelling [PDF]
, 2017 Antibody-drug conjugates (ADCs) are emerging as a promising class of selective drug delivery systems in the battle against cancer and other diseases.
Ekholm, Filip S. +2 more
core +2 more sources
Two‐Step Biocatalytic Synthesis of (1S)‐Nor(pseudo)ephedrine Catalyzed by Immobilized Enzymes
ChemCatChem, Volume 16, Issue 19, October 7, 2024.A biocatalytic cascade was designed for the synthesis of (1S,2S)‐norpseudoephedrine [(1S,2S)‐NPE] and (1S,2R)‐norephedrine [(1S,2R)‐NE], involving a benzoin‐type condensation catalyzed by (S)‐selective acetoin:dichlorophenolindophenol oxidoreductase (Ao : DCPIP OR), followed by a transamination mediated by (S)‐ or (R)‐selective amine transaminase (ATA).
Stefania Patti +7 more
wiley +1 more source
Golden Guardians: Advanced pH Sensors with Built‐in Antimicrobial Defense
Advanced Optical Materials, Volume 12, Issue 30, October 24, 2024.Ultrasmall norephedrine‐capped gold nanoclusters (Au@Nore) exhibit high photoluminescence (ΦPL of up to 33%) reversible ratiometric pH sensing and pH‐dependent antimicrobial activity. They enabled us to evaluate the pH sensing and their biological effect on bacteria and yeast. Abstract Gold nanoclusters (Au NCs) capped with a small biomolecule, namely (
Miguel Justo‐Tirado +6 more
wiley +1 more source
Substrate specificity of amine oxidase [PDF]
, 1943 The tyramine oxidase activity of liver extracts found by Hare (1), the aliphatic amine oxidase activity of brain, kidney, and liver extracts observed by Pugh and Quastel (2), and the adrenalin oxidase activity of similar extracts noted by Blaschko ...
Alles, Gordon A., Heegaard, Erik V.
core
Scope of partial least-squares regression applied to the enantiomeric composition determination of ketoprofen from strongly overlapped chromatographic profiles [PDF]
, 2015 Valuable quantitative information could be obtained from strongly overlapped chromatographic profiles of two enantiomers by using proper chemometric methods.
Agranat +34 more
core +2 more sources