Results 31 to 40 of about 2,270 (113)

The natural evolution of untreated deep endometriosis and the effect of hormonal suppression: A systematic literature review and meta‐analysis

open access: yesActa Obstetricia et Gynecologica Scandinavica, Volume 103, Issue 9, Page 1722-1735, September 2024.
The overall estimate of the percentage of deep endometriotic lesion progression over time in untreated individuals was 21.4%, whereas it was 12.4% during various hormonal treatments. The potential serious complications of uncontrolled lesion progression, such as bowel occlusion and ureteral stenosis with kidney failure should be taken into account ...
Veronica Bandini   +5 more
wiley   +1 more source

Current understanding on pharmacokinetics, clinical efficacy and safety of progestins for treating pain associated to endometriosis [PDF]

open access: yes, 2018
Introduction: Endometriosis is a chronic estrogen and progestogen responsive inflammatory disease associated with pain symptoms and infertility. The medical therapy of endometriosis aims to induce decidualization within the hormonally dependent ectopic ...
Barra, Fabio   +2 more
core   +1 more source

Clinical pharmacology considerations and drug–drug interactions with long‐acting cabotegravir and rilpivirine relevant to sub‐Saharan Africa

open access: yesBritish Journal of Clinical Pharmacology, Volume 90, Issue 9, Page 2079-2091, September 2024.
Long‐acting injectable (LAI) cabotegravir and rilpivirine for HIV treatment and LAI cabotegravir for pre‐exposure HIV prophylaxis are being rolled out in a multitude of countries worldwide. Due to the prolonged exposure, it can be challenging to undertake ‘traditional’ pharmacokinetic studies and current guidance is derived from their oral equivalents ...
Adrian Steulet   +5 more
wiley   +1 more source

Potential of Typha angustifolia L. in removing norethindrone from water [PDF]

open access: yes, 2018
Uncontrollable demand of pharmaceutical especially contraception drugs and poor performance of conventional wastewater treatment plants has resulted in the increasing concentration of pharmaceutical residues in natural environment.
Kartini Saibeh   +2 more
core  

Treatment of relapsed/refractory severe aplastic anemia in children: Evidence‐based recommendations

open access: yesPediatric Blood &Cancer, Volume 71, Issue 8, August 2024.
Abstract Severe aplastic anemia (SAA) is a rare potentially fatal hematologic disorder. Although overall outcomes with treatment are excellent, there are variations in management approach, including differences in treatment between adult and pediatric patients. Certain aspects of treatment are under active investigation in clinical trials.
Kristin A. Shimano   +18 more
wiley   +1 more source

The influence of oral contraceptives on the exercise pressor reflex in the upper and lower body

open access: yesPhysiological Reports, Volume 12, Issue 13, July 2024.
Abstract Previous research has demonstrated that oral contraceptive (OC) users have enhanced cardiorespiratory responses to arm metaboreflex activation (i.e., postexercise circulatory occlusion, PECO) and attenuated pressor responses to leg passive movement (PM) compared to non‐OC users (NOC).
T. J. Pereira, H. Edgell
wiley   +1 more source

The effect of endothelin a receptor inhibition and biological sex on cutaneous microvascular function in non‐Hispanic Black and White young adults

open access: yesPhysiological Reports, Volume 12, Issue 14, July 2024.
Abstract The purpose of this study was to investigate whether endothelin‐A receptor (ETAR) inhibition in non‐Hispanic Black (NHB) and White (NHW) young adults depends on biological sex. We recruited females during low hormone (n = 22) and high hormone (n = 22) phases, and males (n = 22).
Casey G. Turner   +4 more
wiley   +1 more source

Hydrothermal Endometrial Ablation Can Reduce the Need for Hysterectomy and Transfusion [PDF]

open access: yes, 2010
The authors report that hydrothermal ablation can obviate the necessity for transfusion in cases of persistent uterine bleeding secondary to large submucosal and intrauterine myomas that are resistant to medical ...
Goldfarb, Herbert A.   +2 more
core   +2 more sources

Bioequivalence of Elagolix/Estradiol/Norethindrone Acetate Fixed‐Dose Combination Product: Phase 1 Results in Healthy Pre‐ and Postmenopausal Women

open access: yesClinical Pharmacology in Drug Development, Volume 13, Issue 6, Page 601-610, June 2024.
Abstract Fixed‐dose combination (FDC) therapies can enhance patient convenience and adherence to prescribed treatment regimens. Elagolix is a novel oral gonadotropin‐releasing hormone receptor antagonist approved for management of moderate to severe pain associated with endometriosis and heavy menstrual bleeding associated with uterine fibroids ...
Mong‐Jen Chen   +5 more
wiley   +1 more source

Effect of vitamin D supplementation on blood pressure:a systematic review and meta-analysis incorporating individual patient data [PDF]

open access: yes, 2015
D-PRESSURE Collaboration: et al.[Importance]: Low levels of vitamin D are associated with elevated blood pressure (BP) and future cardiovascular events.
Alvarez, Jessica   +21 more
core   +3 more sources

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