Results 41 to 50 of about 5,761 (235)

The Progestin Revolution: progestins are arising as the dominant players in the tight interlink between contraceptives and bleeding control

Contraception and Reproductive Medicine, 2021
Since the introduction of the first modern contraceptive methods, the interlink between bleeding control and contraceptive development has been a dominant and critical factor.
Donna Shoupe
doaj   +1 more source

Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences [PDF]

, 2015
Herbal medicines are currently in high demand, and their popularity is steadily increasing. Because of their perceived effectiveness, fewer side effects and relatively low cost, they are being used for the management of numerous medical conditions ...
Horie, Toshiharu, Oga, Enoche Florence, Sekine, Shuichi, Shitara, Yoshihisa   +3 more
core   +1 more source

Developments with hormonal contraceptives for elephants

Pachyderm, 1996
Only a summary of the presentation was published. Outlines the ongoing research into the use of hormonal contraceptive initiated to develop as an alternative to culling.
Aarde, van
doaj   +1 more source

Pharmacokinetic and Drug–Drug Interaction Profiles of the Combination of Tezacaftor/Ivacaftor

Clinical and Translational Science, 2019
Drug–drug interaction (DDI) studies are described for tezacaftor/ivacaftor, a new cystic fibrosis transmembrane conductance regulator modulator therapy for the treatment of cystic fibrosis.
Varun Garg, Jinshan Shen, Chonghua Li, Sagar Agarwal, Asfiha Gebre, Sarah Robertson, Jiayin Huang, Linda Han, Licong Jiang, Kristin Stephan, Linda T. Wang, Julie Lekstrom‐Himes   +11 more
doaj   +1 more source

Effect of letrozole on masculinization of Siamese fighting fish (Betta splendens) [PDF]

, 2015
The aim of this study was to evaluate the effect of letrozole (a non-steroidal aromatase inhibitor) on masculinization of Siamese fighting fish (Betta splendens).
Archana, Chirom, Basavaraja, N., Joshi, Harshavardhan D., Katare, Milind B.   +3 more
core   +2 more sources

Integrating transcriptomics and network analysis-based multiplexed drug repurposing to screen drug candidates for M2 macrophage-associated castration-resistant prostate cancer bone metastases

Frontiers in Immunology, 2022
Metastatic castration-resistant prostate cancer (CRPC) has long been considered to be associated with patient mortality. Among metastatic organs, bone is the most common metastatic site, with more than 90% of advanced patients developing bone metastases (
Jinyuan Chang, Zhenglong Jiang, Tianyu Ma, Jie Li, Jiayang Chen, Peizhi Ye, Li Feng   +6 more
doaj   +1 more source

Effect of Elagolix Exposure on Clinical Efficacy End Points in Phase III Trials in Women With Endometriosis‐Associated Pain: An Application of Markov Model

CPT: Pharmacometrics & Systems Pharmacology, 2020
Elagolix is an oral gonadotropin‐releasing hormone antagonist approved by the US Food and Drug Administration (FDA) for the management of moderate‐to‐severe pain associated with endometriosis and in combination with estradiol/norethindrone acetate ...
Insa Winzenborg, Akshanth R. Polepally, Ahmed Nader, Nael M. Mostafa, Peter Noertersheuser, Juki Ng   +5 more
doaj   +1 more source

Effect of Zhuyun I Recipe Capsule Enema on the Immune Microenvironment of the Endometrium during Implantation Window in Rats

Emergency Medicine International, 2022
Background. Preterm birth is the leading cause of neonatal death, and there are no effective clinical means for the prevention and treatment of spontaneous preterm birth, mainly because the mechanism for labor initiation has not been fully elucidated ...
Hang Zhou, Pei Guo, Pengfei Zeng, Zhixing Yin, Li Yan, Jinzhu Huang, Yi Wang, Juan Li, Wanting Xia, Yang Wang, Chang Liu, Qian Zeng   +11 more
doaj   +1 more source

Occurrence and seasonal distribution of steroid hormones and bisphenol A in surface waters and suspended sediments of Quebec, Canada

Environmental Advances, 2022
Limited information is available regarding the seasonal and spatial distribution of endocrine disrupting compounds (EDCs) in Canadian surface waters. Using improved analytical methods, we set out to evaluate the occurrence and risks of 15 EPA-priority ...
Ken Goeury, Gabriel Munoz, Sung Vo Duy, Michèle Prévost, Sébastien Sauvé   +4 more
doaj   +1 more source

A Scoping Systematic Review of Cannabis Use in Endometriosis

Australian and New Zealand Journal of Obstetrics and Gynaecology, EarlyView.
ABSTRACT Background Endometriosis, affecting 6%–10% of reproductive‐age women, causes chronic pelvic pain, dysmenorrhea, and infertility. Current treatments have limitations and consequently there is rising interest in effects of cannabis on pain and inflammation associated with endometriosis.
Kindha McLaren, Simon Erridge, Mikael H. Sodergren   +2 more
wiley   +1 more source