Results 71 to 80 of about 2,270 (113)
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Study of Norethindrone in Contraception
JAMA, 1962Norethindrone was given to 210 women as a contraceptive, at a dose of 10 mg. per day for 20 days of each menstrual cycle, in order to determine what maximal effectiveness could be achieved in a carefully designed field trial. In a total of 6,232 cycles there were no pregnancies and no rejections of the treatment due to side effects.
Joseph W. Goldzieher +2 more
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Pharmacokinetics of norethindrone acetate in women
American Journal of Obstetrics and Gynecology, 1979The plasma half-life, MCR and plasma metabolite levels at various time intervals have been studied in six women after an intravenous injection of 3H-norethindrone acetate. The disappearance curve due to norethindrone acetate showed an initial rapid disappearance of 3H with an average half-life of 7.5 minutes and a subsequent slow disapperance with a ...
K. Murugesan +6 more
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Plasma levels of norethindrone after I.M. injection of 200 mg norethindrone enanthate
Contraception, 1975Abstract The plasma levels of norethindrone were measured with a radioimmunoassay after an intramuscular injection of 200 mg of norethindrone enanthate in five healthy women. After an initial peak of norethindrone between 8–14.5 ng/ml, a gradual decline followed. The concentration of 1 ng/ml was reached after approximately 45 days. The plasma pattern
Erik Weiner, Elof D. B. Johansson
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Clinical Endocrinology, 1979
SUMMARYSingle oral doses of 0.3 mg, 0.5 mg and 5 mg Norethindrone (NET) and 0.5 mg and 5 mg Lynestrenol (lyn) were given to five women. Lynestrenol is probably metabolized through NET and exerts its main biological activity as NET. Plasma concentrations of NET were determined by a radioimmunoassay at different intervals after administration of the ...
V. Odlind +3 more
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SUMMARYSingle oral doses of 0.3 mg, 0.5 mg and 5 mg Norethindrone (NET) and 0.5 mg and 5 mg Lynestrenol (lyn) were given to five women. Lynestrenol is probably metabolized through NET and exerts its main biological activity as NET. Plasma concentrations of NET were determined by a radioimmunoassay at different intervals after administration of the ...
V. Odlind +3 more
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Pharmacokinetics of norethindrone in Indian women
Contraception, 1979Pharmacokinetics of norethindrone (NET) was evaluated in eleven women belonging to a low socio-economic group and in five womem belonging to the high socio-economic group after the administration of an oral dose of 0.35 mg NET minipill on an empty stomach. Blood samples were collected at different intervals of time over a period of 24 hours. Plasma NET
B. Sivakumar +3 more
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Bioavailability of norethindrone in human subjects
European Journal of Clinical Pharmacology, 1978A competitive protein binding assay for norethindrone was developed to measure plasma levels in human subjects. The plasma levels were considerably higher in women than in men, especially at low dose levels. The plasma levels were directly related to the dose in men; but greater variations in the plasma levels were observed in women.
Thomas C. Smith +4 more
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Norethindrone in Serum After use of an oral Contraceptive Containing Norethindrone Acetate
Acta Obstetricia et Gynecologica Scandinavica, 1983Abstract. The availability of norethindrone (NET) in serum was studied in 8 women after daily administration of a combination oral contraceptive pill (MinovlarR) containing 1 mg norethindrone acetate (NETA) and 50 μg ethinyl estradiol (EE2) from day 5 to day 25 of the menstrual cycle. The pill was taken daily at 9.30 a.m.
Vimla Laumas +4 more
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Contraception, 1991
Subdermal silastic implants releasing norethindrone acetate were inserted in five rhesus monkeys for a period of seven months. The serum norethindrone (NET) levels were estimated from blood samples collected fortnightly. There was an initial high level of NET followed by fluctuating levels of NET in 4 out of five monkeys.
A. Farooq, P. Jha, K. Murugesan
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Subdermal silastic implants releasing norethindrone acetate were inserted in five rhesus monkeys for a period of seven months. The serum norethindrone (NET) levels were estimated from blood samples collected fortnightly. There was an initial high level of NET followed by fluctuating levels of NET in 4 out of five monkeys.
A. Farooq, P. Jha, K. Murugesan
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Structure of the Isonicotinyl Hydrazone of Norethindrone
Journal of Pharmaceutical Sciences, 1983The contraceptive steroid norethindrone reacts with isoniazid both in vivo and in vitro to give the corresponding hydrazone, which exists as syn and anti (with respect to C-4) isomers. These isomers rapidly interconvert, with the anti form predominating in solution.
Allan Menzies +2 more
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Influence of aspirin on the pharma of norethindrone
Contraception, 1987Abstract The influence of a single dose of aspirin on the pharmacokinetics of the synthetic progestogen norethindrone was studied in rabbits. It was found that neither the 24-hr plasma levels nor the pharmacokinetic parameters of norethindrone following intravenous dosing were significantly altered by aspirin.
Mohamed H. Makarm, Adel A. Gomaa
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