Results 11 to 20 of about 961 (135)

Analysis of Adherence to Fluoxetine Treatment through its Plasma Concentration

Brazilian Journal of Pharmaceutical Sciences, 2023
Depression plays an important role in non-adherence to medical recommendations. Fluoxetine is a first line of depression treatment. This study aimed to evaluate adherence to drug therapy in fluoxetine users by different methods. A cross-section study was
Juliana Raquel Raasch, Tainara Gomes Vargas, Andressa Schmidt dos Santos, Roberta Ziles Hahn, Anne Caroline Cezimbra da Silva, Marina Venzon Antunes, Rafael Linden, Andresa Heemann Betti, Magda Susana Perassolo   +8 more
doaj   +1 more source

Assessing the Mechanism of Fluoxetine-Mediated CYP2D6 Inhibition

Pharmaceutics, 2021
Fluoxetine is still one of the most widely used antidepressants in the world. The drug is extensively metabolized by several cytochrome P450 (CYP450) enzymes and subjected to a myriad of CYP450-mediated drug interactions.
Malavika Deodhar, Sweilem B. Al Rihani, Lucy Darakjian, Jacques Turgeon, Veronique Michaud   +4 more
doaj   +1 more source

Factors associated with fluoxetine and norfluoxetine plasma concentrations and clinical response in Mexican patients with mental disorders

Pharmacology Research & Perspectives, 2021
Over the last few years, fluoxetine has been one of the most prescribed medications for the treatment of diverse psychiatric conditions in Mexico.
Julia Sagahón‐Azúa, Susanna Edith Medellín‐Garibay, Cinthya Eloisa Chávez‐Castillo, César Guillermo González‐Salinas, Rosa del Carmen Milán‐Segovia, Silvia Romano‐Moreno   +5 more
doaj   +1 more source

Fluoxetine and its metabolite norfluoxetine induce microglial apoptosis [PDF]

Journal of Neurochemistry, 2019
AbstractInflammatory insult to the central nervous system (CNS) can lead to development of depression, and subsequently depression is the most frequent psychiatric comorbidity following ischemic stroke, often limiting recovery and rehabilitation in patients. The initiators of inflammatory pathways in the CNS are microglia activated in response to acute
Kamaldeep S. Dhami, Matthew A. Churchward, Glen B. Baker, Kathryn G. Todd   +3 more
openaire   +2 more sources

Behavioral Therapy and Fluoxetine Treatment in Aggressive Dogs: A Case Study

Animals, 2020
Canine aggression is a major concern, affecting millions of people worldwide, and treatment can be challenging even for skilled veterinarians. Empiric use of fluoxetine is sometimes attempted, although few data regarding long-term effects in aggressive ...
Rosangela Odore, Diego Rendini, Paola Badino, Giulia Gardini, Giulia Cagnotti, Valentina Meucci, Luigi Intorre, Claudio Bellino, Antonio D’Angelo   +8 more
doaj   +1 more source

Unraveling the Molecular Reason of Opposing Effects of α-Mangostin and Norfluoxetine on TREK-2 at the Same Binding Site. [PDF]

ChemMedChem
TWIK‐related K+ channel (TREK)‐2 has been considered as a promising target for the development of new analgesics, and it was demonstrated that α‐mangostin, a potent activator of TREK‐2, shares a binding site with the well‐known inhibitor of TREK‐2, norfluoxetine.
Kim G, Van NTH, Nam JH, Lee W.
europepmc   +2 more sources

Multiple Effects of Echinochrome A on Selected Ion Channels Implicated in Skin Physiology

Marine Drugs, 2023
Echinochrome A (Ech A), a naphthoquinoid pigment from sea urchins, is known to have anti-inflammatory and analgesic effects that have been suggested to be mediated by antioxidant activity and intracellular signaling modulation.
Sung Eun Kim, Elina Da Sol Chung, Elena A. Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Hyoung Kyu Kim, Joo Hyun Nam, Sung Joon Kim   +8 more
doaj   +1 more source

Distribution and excretion of fluoxetine and norfluoxetine in human milk [PDF]

British Journal of Clinical Pharmacology, 1999
Aims To characterize milk/plasma (M/P) ratio and infant dose, for fluoxetine and norfluoxetine, in breast‐feeding women taking fluoxetine for the treatment of depression, and to determine the plasma concentration of these drugs in their infants.
J H, Kristensen, K F, Ilett, L P, Hackett, P, Yapp, M, Paech, E J, Begg   +5 more
openaire   +2 more sources

High risk of drug toxicity in social isolation stress due to liver dysfunction: Role of oxidative stress and inflammation

Brain and Behavior, 2021
Background: Previous studies have shown that social isolation stress (SIS) could associate with several systemic diseases; however, the role of SIS on liver dysfunction has yet to be established. This study aimed to investigate the effect of SIS on liver
Maziar Zahir, Siavash Shariatzadeh, Ayda Khosravi, Fatima Ahmed Alshaikh, Parichehr Moradi, Milad Ghaderi, Parsa Farsinejad, Parisa Afraz Louyeh, Saba Ilkhani, Pooria Nakhaei, Amin Taheri, Avid Farhang Fagheh, Reza Akhavan‐Sigari   +12 more
doaj   +1 more source

Different Classes of Antidepressants Inhibit the Rat α7 Nicotinic Acetylcholine Receptor by Interacting within the Ion Channel: A Functional and Structural Study

Molecules, 2021
Several antidepressants inhibit nicotinic acetylcholine receptors (nAChRs) in a non-competitive and voltage-dependent fashion. Here, we asked whether antidepressants with a different structure and pharmacological profile modulate the rat α7 nAChR through
Yorley Duarte, Maximiliano Rojas, Jonathan Canan, Edwin G. Pérez, Fernando González-Nilo, Jesús García-Colunga   +5 more
doaj   +1 more source