Results 21 to 30 of about 961 (135)
Oxidative and apoptotic effects of fluoxetine and its metabolite norfluoxetine in Daphnia magna
Arhiv za Higijenu Rada i Toksikologiju, 2020 The aim of this study was to investigate the oxidative and apoptotic potential of fluoxetine, a widely used antidepressant in Turkey and the world, and of its metabolite norfluoxetine on a model non-target organism, Daphnia magna to see how exposure to ...
Över Sevgi Başalan +3 more
doaj +1 more source
In vitro modulation of estrogen receptor activity by norfluoxetine [PDF]
Medicine and Pharmacy Reports, 2015 Background & Aims: Selective serotonin reuptake inhibitors (SSRIs) are antidepressants increasingly prescribed for pregnancy and postpartum depression. However, these compounds can cross the placenta and also pass into breast milk, thus reaching the fetus and infant during critical developmental stages, potentially causing adverse effects ...
LUPU, DIANA +4 more
openaire +2 more sources
Quantitative cross-species extrapolation between humans and fish: the case of the anti-depressant fluoxetine. [PDF]
PLoS ONE, 2014 Fish are an important model for the pharmacological and toxicological characterization of human pharmaceuticals in drug discovery, drug safety assessment and environmental toxicology. However, do fish respond to pharmaceuticals as humans do?
Luigi Margiotta-Casaluci +7 more
doaj +1 more source
Pharmaceutics, 2023 Fluoxetine is the recommended first-line antidepressant in many therapeutic guidelines for children and adolescents. However, little is known about the relationships between drug dose and serum level as well as the therapeutic serum reference range in ...
Michael Frey +32 more
doaj +1 more source
Block of TREK and TRESK K2P channels by lamotrigine and two derivatives sipatrigine and CEN-092
Biochemistry and Biophysics Reports, 2021 TREK and TRESK K2P channels are widely expressed in the nervous system, particularly in sensory neurons, where they regulate neuronal excitability. In this study, using whole-cell patch-clamp electrophysiology, we characterise the inhibitory effect of ...
Yvonne Walsh +3 more
doaj +1 more source
Physiological Reports, Volume 11, Issue 23, December 2023., 2023 Abstract At the end of gestation, fetal skeleton rapidly accumulates calcium, and bone development continues in offspring postnatally. To accommodate, maternal skeletal physiology is modulated in a serotonin‐dependent manner. Selective serotonin reuptake inhibitors (SSRIs) are generally considered safe for treatment of major depressive disorder ...
Hannah P. Fricke +6 more
wiley +1 more source
Rules of Thumb for Estimating Drug Levels in Breast Milk: How Well Do They Work? [PDF]
Clin Pharmacol TherThe American Academy of Pediatrics and the World Health Organization recommend exclusive breastfeeding for the first 6 months of life due to extensive benefits for the maternal–infant dyad. While over 90% of mothers initiate breastfeeding, continuation drops to 35% by 6 months, often due to concerns about medication safety.
Gasparyan J +3 more
europepmc +2 more sources
The Concise Guide to PHARMACOLOGY 2023/24: Ion channels
British Journal of Pharmacology, Volume 180, Issue S2, Page S145-S222, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander +72 more
wiley +1 more source
Drug-facilitated crime: A review of findings between 2019 and 2023. [PDF]
J Forensic SciAbstract Drug‐facilitated crime (DFC) is a criminal act (e.g., assault, robbery, or sexual assault) in which the perpetrator uses drugs to impair the victim's ability to resist, remember, or recognize the crime being committed. Ethanol is commonly implicated in DFC casework, but limited data are published on other substances currently implicated in ...
Hessler MR, Kacinko SL, Logan BK.
europepmc +2 more sources
Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids [PDF]
Proceedings of the National Academy of Sciences, 2004 Mice housed in social isolation exhibit a decreased response to γ-aminobutyric acid-mimetic drugs [i.e., pentobarbital (PTB)] associated with a down-regulation of telencephalic allopregnanolone (Allo) levels. In these mice, the PTB-induced loss of righting reflex is greatly reduced.
Graziano, Pinna +2 more
openaire +2 more sources