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Photophysics of norharmane in micellar environments: a fluorometric study
Biophysical Chemistry, 2004Steady state photophysics of norharmane (NHM) has been studied in different aqueous micellar environments. In aqueous solution at pH 7, excitation of the neutral species promotes a rapid transfer of proton giving rise to the corresponding cationic emission. Aqueous micelles differing in their surface charge characteristics interact with the fluorophore
Arabinda, Mallick, Nitin, Chattopadhyay
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In vitro and in vivo formation of aminophenylnorharman from norharman and aniline
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2002Norharman is not mutagenic to Salmonella strains, but becomes so to S. typhimurium TA98 and YG1024 with S9 mix in the presence of the non-mutagenic aromatic amine, aniline. The mutagenicity from norharman and aniline in the presence of S9 mix is reported to be due to formation of a mutagenic compound, 9-(4'-aminophenyl)-9H-pyrido[3,4-b]indole ...
Yukari, Totsuka +4 more
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Norharman and ellipticine: A comparison of their abilities to interact with DNA in vitro
Cancer Letters, 1980The anti-tumor agent ellipticine has been compared in vitro with the bacterial co-mutagen norharman, a compound which it resembles superfically in chemical structure. Ellipticine was shown to stabilize the structure of double stranded calf-thymus DNA, to induce mutations in strain TA153 of Salmonella tryhimurium and to cause BHK cells to transform ...
J, Ashby, B M, Elliott, J A, Styles
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Norharmane as a potential chemical entity for development of anticancer drugs
European Journal of Medicinal Chemistry, 2019Cancer is a leading cause of death generally, and to overcome this problem the introduction of a new drug developing is a continuous endeavour. An alkaloid, norharmane and its derivatives, which have anticancer activities, widely distributed in several living and synthetic chemical sources.
Chita Ranjan Sahoo +2 more
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Factors Influencing the Norharman and Harman Contents in Espresso Coffee
Journal of Agricultural and Food Chemistry, 2007Espresso coffee (EC) brews were analyzed for beta-carboline [norharman (NH) and harman (H)] contents, by RP-HPLC with fluorescence detection. The influence of the coffee species (arabica or robusta), the roast degree, and the brew length was studied.
Rita C, Alves +2 more
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Norharman inhibition of [3H]-diazepam binding in mouse brain
Life Sciences, 1981Abstract Norharman competitively inhibits specific binding of [ 3 H]-diazepam in mouse brain homogenates. In vivo this β-carboline produces a striking rigid catatonic-like appearance which is abolished by diazepam. It also causes a rapid tremor but has little anticonvulsant effect.
A M, Morin, I A, Tanaka, C G, Wasterlain
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Cyclodextrins modify the proton transfer photoreactions of norharmane
Journal of Photochemistry and Photobiology A: Chemistry, 2005Abstract Excited state proton transfer reactions of norharmane have been investigated in the presence of cyclodextrins (CDs): β-CD and modified β-CDs at pH values of 4.0, 7.8, 10.0 and 13.0. The spectral shape and the species present in the equilibria depend on the CDs and the pH of the media.
José L. Prados +4 more
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β-carbolines norharman and harman in vegetable oils in China
Food Additives & Contaminants: Part B, 2020The beta-carbolines norharman and harman, two heterocyclic aromatic amines with potential mutagenicity, have been determined in vegetable oils. Identification and analysis were carried out by ultra-performance liquid chromatography-triple quadrupole tandem mass spectrometry (UPLC-MS/MS).
Chen-Xia Zhang +4 more
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Antimicrobial and autophototoxic effects of norharmane in termites
2004The fluorescent alkaloid norharmane has been isolated from Reticulitermes termites and characterized by microcoil 1H NMR, UV/Vis, mass spectrometry and GC/MS. This is the first report of norharmane in insects, which is the major component in termite fluorescence under ultraviolet light.
Siderhurst, Matthew Samuel +4 more
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Photophysical behavior of norharmane related to proximity effect
Journal of Luminescence, 1990Abstract Solvent and temperature effects of fluorescence and its polarization characteristics for norharmane were studied. From the results obtained it is concluded that the fluorescent state changes from the φφ ∗ -type in a polar solvent (EPA) to nφ ∗ -type in a nonpolar solvent (MC), and also that lowest singlet excited states (φφ ∗ -type and nφ ∗
A. Olba, F. Tomas, I. Zabala
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