Results 131 to 140 of about 792 (188)

The Acidity of Weak NH Acids: Expanding the p<i>K</i> <sub>a</sub> Scale in Acetonitrile. [PDF]

open access: yesACS Org Inorg Au
Lõkov M   +7 more
europepmc   +1 more source

Exposure to β-carbolines norharman and harman

open access: yesJournal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2004
The aromatic beta-carbolines norharman and harman have been implicated in a number of human diseases including Parkinson's disease, tremor, addiction and cancer. It has been shown that these compounds are normal body constituents formed endogenously but external sources have been identified. Here, we summarise literature data on levels of norharman and
Kerstin Skog
exaly   +5 more sources

The impact of smoking and drinking on plasma levels of norharman

open access: yesEuropean Neuropsychopharmacology, 2002
The hypothesized role of the beta-carboline norharman in processes of drug dependence forms the basis for several studies on plasma levels of norharman among substance-using populations, particularly among alcoholics and smokers. However, it is not clear whether norharman is implicated in processes of dependence to both substances, or only to tobacco ...
Renske Spijkerman   +2 more
exaly   +7 more sources
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Pharmacokinetics of the β-carboline norharman in man

Life Sciences, 2001
In healthy subjects, pharmacokinetics were characterised using single oral and sublingual administrations of the beta-carboline norharman. For this purpose, norharman levels in blood plasma were measured up to 90-105 min after both routes of administration. Dose proportionality of three different single oral doses of norharman (7, 65 and 110 microg/kg)
D Fekkes   +2 more
exaly   +4 more sources

Tryptophan: a precursor for the endogenous synthesis of norharman in man

Neuroscience Letters, 2001
We investigated whether in healthy subjects L-tryptophan may serve as a precursor for the endogenous synthesis of the beta-carboline norharman. For this purpose subjects, smokers as well as non-smokers, received 0 or 1.2 g of an oral dose of tryptophan. Smokers started the experiment 2 h after cessation of smoking.
D Fekkes   +2 more
exaly   +4 more sources

The role of norharman in alcohol dependence and smoking: The potential inhibitory role of norharman on the urge for alcohol and nicotine use

open access: yesJournal of Substance Use, 2005
The aim of this study was to investigate the role of the endogenous substance norharman in processes of alcohol and nicotine or tobacco dependence in both humans and animals. For this purpose heavy smokers and excessive alcohol drinkers were recruited, and rats were made dependent on alcohol and nicotine.
Fekkes, Durk   +3 more
openaire   +2 more sources

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