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The impact of smoking and drinking on plasma levels of norharman
European Neuropsychopharmacology, 2002 The hypothesized role of the beta-carboline norharman in processes of drug dependence forms the basis for several studies on plasma levels of norharman among substance-using populations, particularly among alcoholics and smokers. However, it is not clear whether norharman is implicated in processes of dependence to both substances, or only to tobacco ...
Dike van de Mheen
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Pharmacokinetics of the β-carboline norharman in man
Life Sciences, 2001In healthy subjects, pharmacokinetics were characterised using single oral and sublingual administrations of the beta-carboline norharman. For this purpose, norharman levels in blood plasma were measured up to 90-105 min after both routes of administration. Dose proportionality of three different single oral doses of norharman (7, 65 and 110 microg/kg)
Durk Fekkes +2 more
exaly +4 more sources
Tryptophan: a precursor for the endogenous synthesis of norharman in man
Neuroscience Letters, 2001We investigated whether in healthy subjects L-tryptophan may serve as a precursor for the endogenous synthesis of the beta-carboline norharman. For this purpose subjects, smokers as well as non-smokers, received 0 or 1.2 g of an oral dose of tryptophan. Smokers started the experiment 2 h after cessation of smoking.
Durk Fekkes +2 more
exaly +4 more sources
Effect of norharman on the mutagenicity of toluidine metabolites
Toxicology Letters, 1989Among the different metabolites of o-toluidine only the nitroso and hydroxylamino derivatives were found to be very potent frameshift mutagens in the presence of the co-mutagen norharman and S9. In the absence of norharman and S9 they are only base pair mutagens.
T R Juneja, R L Gupta, R L Gupta
exaly +3 more sources
Journal of Substance Use, 2005 The aim of this study was to investigate the role of the endogenous substance norharman in processes of alcohol and nicotine or tobacco dependence in both humans and animals. For this purpose heavy smokers and excessive alcohol drinkers were recruited, and rats were made dependent on alcohol and nicotine.
Fekkes, Durk +3 more
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Norharman and anxiety disorders
Acta Neuropsychiatrica, 1996SummaryNorharman is a ß-carboline, possibly of endogenous origin, although cigarette smoking and food are sources too. In brain specific binding sites have been demonstrated. In higher doses norharman binds to benzodiazepine receptors and has MAO-B inhibitory activity.
L, Pepplinkhuizen +2 more
openaire +2 more sources
Photochemistry of norharmane in aqueous solution
Photochemical & Photobiological Sciences, 2009The photochemistry of norharmane (9H-pyrido[3,4-b]indole) in acidic (pH 5.0+/-0.1) and alkaline (pH 10.0+/-0.1) aqueous solutions was studied. The photochemical reactions were monitored by TLC, UV/VIS absorption spectroscopy, high-performance liquid chromatography (HPLC), electronic ionization-mass spectrometry (EI-MS), UV-laser desorption/ionization ...
M Micaela, Gonzalez +4 more
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Comutagenic effect of norharman with aminopyridine derivatives
Mutation Research Letters, 1982The mutagenicities of 3 monoaminopyridines, 4 methyl-substituted monoaminopyridines and 3 diaminopyridines were tested with or without norharman in the Salmonella assay system. None of the compounds was mutagenic without norharman. However, 3-aminopyridine and 2-amino-3-methylpyridine were mutagenic in the presence of norharman and S9 mix; 3 ...
K, Wakabayashi +3 more
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Photochemical and sonochemical reactions of norharmane
Journal of Photochemistry and Photobiology A: Chemistry, 1996In this work, a study on the photochemical and sonochemical behaviour of norharmane in halomethane media (dichloromethane, chloroform, carbon tetrachloride and dibromomethane) is presented. When solutions of norharmane in these media are irradiated with UV light or sonicated with ultrasound at 20 or 50 kHz, the cationic species of norharmane appears in
D. Reyman +3 more
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Norharman and alcohol-dependency in male Wistar rats
European Neuropsychopharmacology, 2002We examined the effects of ethanol ingestion to rats on levels of the beta-carboline norharman in plasma, brain and liver at the end of ethanol ingestion and 10 h after withdrawal. We also investigated the effect of exogenously administered norharman on the behavioural signs of alcohol withdrawal.
Fekkes, Durk +2 more
openaire +2 more sources