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The Acidity of Weak NH Acids: Expanding the p<i>K</i> <sub>a</sub> Scale in Acetonitrile. [PDF]
Lõkov M +7 more
europepmc +1 more source
The inhibition effect and mechanism of typical hydrocolloids on the formation of heterocyclic amines: A study based on quantum chemical computation analysis. [PDF]
Huang T +6 more
europepmc +1 more source
Novel endophytic actinomycetes species Streptomyces panacea of Panax sokpayensis produce antimicrobial compounds against multidrug resistant Staphylococcus aureus. [PDF]
Rai S +5 more
europepmc +1 more source
Exposure to β-carbolines norharman and harman
The aromatic beta-carbolines norharman and harman have been implicated in a number of human diseases including Parkinson's disease, tremor, addiction and cancer. It has been shown that these compounds are normal body constituents formed endogenously but external sources have been identified. Here, we summarise literature data on levels of norharman and
Kerstin Skog
exaly +5 more sources
The impact of smoking and drinking on plasma levels of norharman
The hypothesized role of the beta-carboline norharman in processes of drug dependence forms the basis for several studies on plasma levels of norharman among substance-using populations, particularly among alcoholics and smokers. However, it is not clear whether norharman is implicated in processes of dependence to both substances, or only to tobacco ...
Renske Spijkerman +2 more
exaly +7 more sources
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Pharmacokinetics of the β-carboline norharman in man
Life Sciences, 2001In healthy subjects, pharmacokinetics were characterised using single oral and sublingual administrations of the beta-carboline norharman. For this purpose, norharman levels in blood plasma were measured up to 90-105 min after both routes of administration. Dose proportionality of three different single oral doses of norharman (7, 65 and 110 microg/kg)
D Fekkes +2 more
exaly +4 more sources
Tryptophan: a precursor for the endogenous synthesis of norharman in man
Neuroscience Letters, 2001We investigated whether in healthy subjects L-tryptophan may serve as a precursor for the endogenous synthesis of the beta-carboline norharman. For this purpose subjects, smokers as well as non-smokers, received 0 or 1.2 g of an oral dose of tryptophan. Smokers started the experiment 2 h after cessation of smoking.
D Fekkes +2 more
exaly +4 more sources
The aim of this study was to investigate the role of the endogenous substance norharman in processes of alcohol and nicotine or tobacco dependence in both humans and animals. For this purpose heavy smokers and excessive alcohol drinkers were recruited, and rats were made dependent on alcohol and nicotine.
Fekkes, Durk +3 more
openaire +2 more sources

