Results 141 to 150 of about 911 (180)

Mutagenicities of mono-nitrobenzene derivatives in the presence of norharman

Mutation Research Letters, 1983
The mutagenicities of 22 mono-nitrobenzene derivatives, i.e., nitrobenzene [98-95-3] and the ortho, meta and para isomers of nitrotoluene [88-72-2, 99-08-1, 99-99-0], nitrophenol [88-75-5, 554-84-7, 100-02-7], nitroanisole [91-23-6, 555-03-3, 100-17-4], nitrochlorobenzene [88-73-3, 121-73-3, 100-00-5], nitrobenzoic acid [552-16-9, 121-92-6, 62-23-7 ...
J, Suzuki, T, Koyama, S, Suzuki
openaire   +2 more sources

Chronic effects of norharman in rats treated with aniline

Toxicology Letters, 1980
The carcinogenic effects of aniline and norharman given alone or in combination were examined in rats. Neoplastic changes including hyperplastic changes of the urinary bladder were not found in all groups. Papillomas of forestomach were observed in 5 rats out of 110 rats. However, this was not significantly different among the groups. Pyelonephritis or
A, Hagiwara, M, Arai, M, Hirose, J I, Nakanowatari, H, Tsuda, N, Ito   +5 more
openaire   +2 more sources

Photophysics of norharmane in micellar environments: a fluorometric study

Biophysical Chemistry, 2004
Steady state photophysics of norharmane (NHM) has been studied in different aqueous micellar environments. In aqueous solution at pH 7, excitation of the neutral species promotes a rapid transfer of proton giving rise to the corresponding cationic emission. Aqueous micelles differing in their surface charge characteristics interact with the fluorophore
Arabinda, Mallick, Nitin, Chattopadhyay
openaire   +2 more sources

Effects of the co-mutagen norharman in rats

Toxicology Letters, 1979
Abstract Studies were made on the acute and subacute toxic effects of the co-mutagen norharman when given orally to male Fischer strain rats. Animals were given diets containing 1500 ppm of norharman for 28 days, and 3 or 6 animals were killed for examination on days 0, 1, 3, 7, 14, 21, and 28.
Gen'i Murasaki, Yukitada Miyata, Tomoyuki Shirai, Masayuki Arai, Takashi Kawachi, Nobuyuki Ito   +5 more
openaire   +1 more source

Prototropic behavior of norharmane within ionic liquids

Journal of Photochemistry and Photobiology A: Chemistry, 2021
Abstract Ionic liquids are established as alternate solvents for several traditional organic solvents as well as aqueous-based media in many areas of chemistry. Proton transfer reactions exhibit a high dependency on the nature of the solubilizing media.
null Bhawna, Divya Dhingra, Ashish Pandey, Siddharth Pandey   +3 more
openaire   +1 more source

In vitro and in vivo formation of aminophenylnorharman from norharman and aniline

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2002
Norharman is not mutagenic to Salmonella strains, but becomes so to S. typhimurium TA98 and YG1024 with S9 mix in the presence of the non-mutagenic aromatic amine, aniline. The mutagenicity from norharman and aniline in the presence of S9 mix is reported to be due to formation of a mutagenic compound, 9-(4'-aminophenyl)-9H-pyrido[3,4-b]indole ...
Yukari, Totsuka, Hiroyuki, Kataoka, Takeji, Takamura-Enya, Takashi, Sugimura, Keiji, Wakabayashi   +4 more
openaire   +2 more sources

Norharman and ellipticine: A comparison of their abilities to interact with DNA in vitro

Cancer Letters, 1980
The anti-tumor agent ellipticine has been compared in vitro with the bacterial co-mutagen norharman, a compound which it resembles superfically in chemical structure. Ellipticine was shown to stabilize the structure of double stranded calf-thymus DNA, to induce mutations in strain TA153 of Salmonella tryhimurium and to cause BHK cells to transform ...
J, Ashby, B M, Elliott, J A, Styles
openaire   +2 more sources

Norharmane as a potential chemical entity for development of anticancer drugs

European Journal of Medicinal Chemistry, 2019
Cancer is a leading cause of death generally, and to overcome this problem the introduction of a new drug developing is a continuous endeavour. An alkaloid, norharmane and its derivatives, which have anticancer activities, widely distributed in several living and synthetic chemical sources.
Chita Ranjan Sahoo, Sudhir Kumar Paidesetty, Rabindra Nath Padhy   +2 more
openaire   +2 more sources

Factors Influencing the Norharman and Harman Contents in Espresso Coffee

Journal of Agricultural and Food Chemistry, 2007
Espresso coffee (EC) brews were analyzed for beta-carboline [norharman (NH) and harman (H)] contents, by RP-HPLC with fluorescence detection. The influence of the coffee species (arabica or robusta), the roast degree, and the brew length was studied.
Rita C, Alves, Susana, Casal, Beatriz P P, Oliveira   +2 more
openaire   +2 more sources

Norharman inhibition of [3H]-diazepam binding in mouse brain

Life Sciences, 1981
Abstract Norharman competitively inhibits specific binding of [ 3 H]-diazepam in mouse brain homogenates. In vivo this β-carboline produces a striking rigid catatonic-like appearance which is abolished by diazepam. It also causes a rapid tremor but has little anticonvulsant effect.
A M, Morin, I A, Tanaka, C G, Wasterlain
openaire   +2 more sources