Results 141 to 150 of about 1,271 (193)

Exposure to β-carbolines norharman and harman

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2004
The aromatic beta-carbolines norharman and harman have been implicated in a number of human diseases including Parkinson's disease, tremor, addiction and cancer. It has been shown that these compounds are normal body constituents formed endogenously but external sources have been identified. Here, we summarise literature data on levels of norharman and
W, Pfau, K, Skog
exaly   +3 more sources

Prototropic behavior of norharmane within ionic liquids

Journal of Photochemistry and Photobiology A: Chemistry, 2021
Abstract Ionic liquids are established as alternate solvents for several traditional organic solvents as well as aqueous-based media in many areas of chemistry. Proton transfer reactions exhibit a high dependency on the nature of the solubilizing media.
null Bhawna, Divya Dhingra, Ashish Pandey, Siddharth Pandey   +3 more
openaire   +1 more source

Norharman and anxiety disorders

Acta Neuropsychiatrica, 1996
SummaryNorharman is a ß-carboline, possibly of endogenous origin, although cigarette smoking and food are sources too. In brain specific binding sites have been demonstrated. In higher doses norharman binds to benzodiazepine receptors and has MAO-B inhibitory activity.
L, Pepplinkhuizen, D, Fekkes, L, Timmerman   +2 more
openaire   +2 more sources

Photochemistry of norharmane in aqueous solution

Photochemical & Photobiological Sciences, 2009
The photochemistry of norharmane (9H-pyrido[3,4-b]indole) in acidic (pH 5.0+/-0.1) and alkaline (pH 10.0+/-0.1) aqueous solutions was studied. The photochemical reactions were monitored by TLC, UV/VIS absorption spectroscopy, high-performance liquid chromatography (HPLC), electronic ionization-mass spectrometry (EI-MS), UV-laser desorption/ionization ...
M Micaela, Gonzalez, M Laura, Salum, Yousef, Gholipour, Franco M, Cabrerizo, Rosa, Erra-Balsells   +4 more
openaire   +2 more sources

Comutagenic effect of norharman with aminopyridine derivatives

Mutation Research Letters, 1982
The mutagenicities of 3 monoaminopyridines, 4 methyl-substituted monoaminopyridines and 3 diaminopyridines were tested with or without norharman in the Salmonella assay system. None of the compounds was mutagenic without norharman. However, 3-aminopyridine and 2-amino-3-methylpyridine were mutagenic in the presence of norharman and S9 mix; 3 ...
K, Wakabayashi, T, Yahagi, M, Nagao, T, Sugimura   +3 more
openaire   +2 more sources

Pharmacokinetics of the β-carboline norharman in man

Life Sciences, 2001
In healthy subjects, pharmacokinetics were characterised using single oral and sublingual administrations of the beta-carboline norharman. For this purpose, norharman levels in blood plasma were measured up to 90-105 min after both routes of administration. Dose proportionality of three different single oral doses of norharman (7, 65 and 110 microg/kg)
Fekkes, Durk, Tuiten, A, Bom, I, Pepplinkhuizen, L (Lolke)   +3 more
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Norharman and alcohol-dependency in male Wistar rats

European Neuropsychopharmacology, 2002
We examined the effects of ethanol ingestion to rats on levels of the beta-carboline norharman in plasma, brain and liver at the end of ethanol ingestion and 10 h after withdrawal. We also investigated the effect of exogenously administered norharman on the behavioural signs of alcohol withdrawal.
Fekkes, Durk, Bernard, HF, Cappendijk, SLT (Susanne)   +2 more
openaire   +2 more sources

Photochemical and sonochemical reactions of norharmane

Journal of Photochemistry and Photobiology A: Chemistry, 1996
In this work, a study on the photochemical and sonochemical behaviour of norharmane in halomethane media (dichloromethane, chloroform, carbon tetrachloride and dibromomethane) is presented. When solutions of norharmane in these media are irradiated with UV light or sonicated with ultrasound at 20 or 50 kHz, the cationic species of norharmane appears in
D. Reyman, A. Pardo, J.M.L. Poyato, J.G. Rodriguez   +3 more
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Chronic effects of norharman in rats treated with aniline

Toxicology Letters, 1980
The carcinogenic effects of aniline and norharman given alone or in combination were examined in rats. Neoplastic changes including hyperplastic changes of the urinary bladder were not found in all groups. Papillomas of forestomach were observed in 5 rats out of 110 rats. However, this was not significantly different among the groups. Pyelonephritis or
A, Hagiwara, M, Arai, M, Hirose, J I, Nakanowatari, H, Tsuda, N, Ito   +5 more
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Photophysical behavior of norharmane related to proximity effect

Journal of Luminescence, 1990
Abstract Solvent and temperature effects of fluorescence and its polarization characteristics for norharmane were studied. From the results obtained it is concluded that the fluorescent state changes from the φφ ∗ -type in a polar solvent (EPA) to nφ ∗ -type in a nonpolar solvent (MC), and also that lowest singlet excited states (φφ ∗ -type and nφ ∗
A. Olba, F. Tomas, I. Zabala
openaire   +1 more source