Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source
The Log-Odd Normal Generalized Family of Distributions with Application
Anais da Academia Brasileira de Ciências: The normal distribution has a central place in distribution theory and statistics. We propose the log-odd normal generalized (LONG) family of distributions based on log-odds and obtain some of its mathematical properties including a useful linear ...
MUHAMMAD ZUBAIR +3 more
doaj +1 more source
On Fixed Accuracy Confidence Interval in Multivariate Normal Distribution with Order 1 Autoregressive Covariance Structure. [PDF]
J Stat Theory Pract, 2023 Sarkar P +2 more
europepmc +1 more source
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
A novel approach to form Normal Distribution of Medical Image Segmentation based on multiple doctors' annotations. [PDF]
Proc SPIE Int Soc Opt Eng, 2022 Zhou Z, Liao G.
europepmc +1 more source
Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value
Molecular Oncology, EarlyView.The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song +13 more
wiley +1 more source
DISTRIBUTION AND EXCRETION OF FOUR TETRACYCLINE ANALOGUES IN NORMAL YOUNG MEN * [PDF]
, 1959 Calvin M. Kunin +2 more
openalex +1 more source
Binary Simulated Normal Distribution Optimizer for feature selection: Theory and application in COVID-19 datasets. [PDF]
Expert Syst Appl, 2022 Ahmed S +3 more
europepmc +1 more source
Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi +26 more
wiley +1 more source
Heteroscedastic partially linear model under skew-normal distribution with application in ragweed pollen concentration. [PDF]
J Appl Stat, 2023 Ferreira CS +2 more
europepmc +1 more source