Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
The Normal Mixture Decomposition [PDF]
This talk will present the program for univariate normal mixture maximum likelihood estimation developed by the author. It will demonstrate the use of -ml lf- estimation method, as well as a number of programming tricks, including global macros ...
Stanislav Kolenikov
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Measuring Inefficiency in Public Utilities: Does the Distribution Matter? [PDF]
In this paper we describe two of the most used distributions for the inefficiency term in a stochastic frontier: the Half Normal and the Exponential distributions.
Rossi, Martín, Canay, Iván
core
Statistical Inference of Truncated Normal Distribution Based on the Generalized Progressive Hybrid Censoring. [PDF]
Entropy (Basel), 2021 Zeng X, Gui W.
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Robust Estimation of Multiple Regression Model with Non-normal Error: Symmetric Distribution [PDF]
In this paper, we develop the modified maximum likelihood (MML) estimators for the multiple regression coefficients in linear model with the underlying distribution assumed to be symmetric, one of Student's t family.
Wing-Keung Wong, Guorui Bian
core
Using the half normal distribution to quantify covariate balance in cluster-randomized pragmatic trials. [PDF]
Trials, 2021 Huang J, Roth DL.
europepmc +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Stochastic Volatility Model with Leverage and Asymmetrically Heavy-tailed Error Using GH Skew Student's t-distribution [PDF]
Bayesian analysis of a stochastic volatility model with a generalized hyperbolic (GH) skew Student's t-error distribution is described where we first consider an asymmetric heavy-tailness as well as leverage effects. An efficient Markov chain Monte Carlo
Jouchi Nakajima, Yasuhiro Omori
core