Results 151 to 160 of about 1,588,486 (313)

Shearing tests with continuously increasing normal stress

open access: yes, 2006
In the conventional shearing tests the normal force or the normal stiffness are kept constant during the experiment. Sliding under constant normal load occurs in slopes if the environment is not changing during the process.
Ván, Péter, Vásárhelyi, Balázs
core  

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

open access: yesMolecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini   +1 more
wiley   +1 more source

Corrigendum: C2H2 Zinc Finger Proteins: Master Regulators of Abiotic Stress Responses in Plants

open access: yesFrontiers in Plant Science, 2020
Guoliang Han   +6 more
doaj   +1 more source

Structural and stress analysis /

open access: yes, 2005
Structural analysis is the corner stone of civil engineering and all students must obtain a thorough understanding of the techniques available to analyse and predict stress in any structure.
Megson, T. H. G.(Thomas Henry Gordon)
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Physiological and psychological measurements during cognitive stress : comparing the effectiveness of two stress intervention techniques.

open access: yes, 2013
Includes abstract.Includes bibliographical references.BACKGROUND: A high level of stress can be detrimental to work performance and general health; in particular cardiovascular health. Work related stress has an effect on the autonomic nervous system and
Scribani, Stefano Lewis
core  

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

open access: yesMolecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard   +8 more
wiley   +1 more source

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