Results 161 to 170 of about 3,820,734 (347)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Corrigendum: C2H2 Zinc Finger Proteins: Master Regulators of Abiotic Stress Responses in Plants

Frontiers in Plant Science, 2020
Guoliang Han, Chaoxia Lu, Jianrong Guo, Ziqi Qiao, Na Sui, Nianwei Qiu, Baoshan Wang   +6 more
doaj   +1 more source

A GIS-based 3D slope stability analysis method based on the assumed normal stress on the slip surface. [PDF]

Sci Rep, 2020
Yu G, Xie M, Liang J, Farooq A, Williams EJ.   +4 more
europepmc   +1 more source

Is there a Relationship between the Elongational Viscosity and the First Normal Stress Difference in Polymer Solutions?

, 2009
We investigate a variety of different polymer solutions in shear and elongational flow. The shear flow is created in the cone-plate-geometry of a commercial rheometer.
Gier, S., Rafaï, S., Wagner, C., Zell, A.   +3 more
core   +1 more source

Psychological and Emotional Stress among the Students Living in Dormitory: A Comparison between Normal and Depressive Students

, 2015
Seoyoun Kim Hyojae Kim
openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Oxidative stress and DNA damage in peripheral blood mononuclear cells from normal, obese, prediabetic and diabetic persons exposed to adrenaline in vitro

, 2019
Ninoslav Djelić, Milena Radaković, Sunčica Borozan, Vesna Dimirijević-Srećković, Nevena Pajović, Branislav Vejnović, Nevena Borozan, Ezgi Eyluel Bankoglu, Helga Stopper, Zoran Stanimirović   +9 more
openalex   +2 more sources

Is there a relation between the relaxation time measured in CaBER experiments and the first normal stress coefficient? [PDF]

, 2010
Andreas Zell, S. Gier, Salima Rafaı̈, Christian Wagner   +3 more
openalex   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Hospital Staff Report It Is Not Burnout, but a Normal Stress Reaction to an Uncongenial Work Environment: Findings from a Qualitative Study. [PDF]

Int J Environ Res Public Health, 2020
Kendrick M, Kendrick K, Morton P, Taylor NF, Leggat SG.   +4 more
europepmc   +1 more source