Results 21 to 30 of about 2,877,363 (151)

Computer-assisted ex vivo, normothermic small bowel perfusion [PDF]

, 2000
Background: In the present study, a technique for computer-assisted, normothermic, oxygenated, ex vivo, recirculating small bowel perfusion was established as a tool to investigate organ pretreatment protocols and ischemia/reperfusion phenomena.
Theodorou, D., Hammer, C., Schildberg, Friedrich Wilhelm, Eder, M., Land, W., Stangl, M. J., Krapp, J.   +6 more
core   +1 more source

Dilemmas concerning heart procurement in controlled donation after circulatory death

Frontiers in Cardiovascular Medicine, 2023
With an expanding population at risk for heart failure and the resulting increase in patients admitted to the waiting list for heart transplantation, the demand of viable organs exceeds the supply of suitable donor hearts. Use of hearts after circulatory
S. E. Kaffka genaamd Dengler, M. T. Vervoorn, M. Brouwer, J. de Jonge, N. P. van der Kaaij   +4 more
doaj   +1 more source

Flavin Mononucleotide as a Biomarker of Organ Quality—A Pilot Study

Transplantation Direct, 2020
Background. Flavin mononucleotide (FMN), released from damaged mitochondrial complex I during hypothermic liver perfusion, has been shown to be predictive of 90-day graft loss. Normothermic machine perfusion (NMP) and normothermic regional perfusion (NRP)
Lu Wang, MRCS, Emily Thompson, MRCS, Lucy Bates, BSc, Thomas L. Pither, BSc, Sarah A. Hosgood, PhD, Michael L. Nicholson, DSc, Christopher J.E. Watson, MD, Colin Wilson, PhD, Andrew J. Fisher, PhD, Simi Ali, PhD, John H. Dark, FRCS   +10 more
doaj   +1 more source

Liver transplantation with uncontrolled versus controlled DCD donors using normothermic regional perfusion and ex-situ machine perfusion

, 2023
In Italy, 20 minutes of continuous, flat-line electrocardiogram are required for death declaration, which significantly increases the risks of donation after circulatory death (DCD) LT.
Zanierato M., De Carlis L., De Simone P., Di Salvo M., Lauterio A., Ghinolfi D., Torri F., Farnesi F., Patrono D., Buscemi V., Melandro F., Cerchione R., De Carlis R., Morganti R., Romagnoli R.   +14 more
core   +2 more sources

Paving the Road for the Adoption of Normothermic Regional Perfusion in Canada

Critical Care Explorations, 2021
Donation after circulatory determination of death has increased the number of organs available but can result in worse recipient outcomes than organs recovered from donors after neurologic death.
John Basmaji, MD, Charles Weijer, MD, PhD, Anton Skaro, MD, PhD, Andrew Healey, MD, Sam D. Shemie, MD, Marat Slessarev, MD, PhD   +5 more
doaj   +1 more source

Hypothermic, oxygenated perfusion (HOPE) provides cardioprotection via succinate oxidation prior to normothermic perfusion in a rat model of donation after circulatory death (DCD) [PDF]

, 2021
In donation after circulatory death (DCD), cardiac grafts are subjected to warm ischemia in situ, prior to a brief period of cold, static storage (CSS) at procurement, and ex situ, normothermic, machine perfusion (NMP) for transport and graft evaluation.
Arnold, Maria, Wyss, Rahel K., Segiser, Adrian, Carrel, Thierry P, Carrel, Thierry P., Mueller, Matteo, Longnus, Sarah L; https://orcid.org/, Dutkowski, Philipp, Wyss, Rahel K, Longnus, Sarah L., Méndez Carmona, Natalia   +10 more
core   +1 more source

Direct procurement of donor heart with normothermic regional perfusion of abdominal organs. [PDF]

, 2019
PURPOSE: To evaluate if direct procurement of heart is possible in combination with normothermic regional perfusion of abdominal organs in donors after circulatory death.

core   +2 more sources

Reference values and physiological characterization of a specific isolated pig kidney perfusion model [PDF]

, 2007
Background: Models of isolated and perfused kidneys are used to study the effects of drugs, hazardous or toxic substances on renal functions. Since physiological and morphological parameters of small laboratory animal kidneys are difficult to compare to ...
Unger Volker, David A Groneberg, Fischer, Axel, Unger, Volker, Groneberg, Jan David Alexander, Groneberg David A, Volker Unger, Grosse-Siestrup Christian, Fehrenberg Claudia, Meissler, Michael, Axel Fischer, Christian Grosse-Siestrup, Fischer Axel, Meissler Michael, Michael Meissler, Grosse-Siestrup, Christian, Fehrenberg, Claudia, Claudia Fehrenberg   +17 more
core   +1 more source

Alternative Preservation Strategies of Donation After Circulatory Death Hearts: Effect of Cold Ischemia Time Before Normothermic Machine Perfusion

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Donation after circulatory death (DCD) offers a promising strategy to expand the donor pool by 20% to 30%. However, DCD heart grafts experience warm ischemia injury, making effective graft viability assessment before transplantation prudent ...
Manuela Lopera Higuita, Emmanuella O. Ajenu, Maya Bolger‐Chen, George Olverson, Soheila Ali Akbari Ghavimi, Si Young Lee, Taku Kasai, William Michaud, Chukwudi Chijioke, Bhuban Ruidas, Allison Pitti, Nathan Minie, Joseph Catricala, Doug Vincent, Selena Li, David D'Alessandro, Elena Aikawa, Sasha A. Singh, Marie Billaud, Asishana A. Osho, Shannon N. Tessier, S. Alireza Rabi   +21 more
doaj   +1 more source

In-situ normothermic regional perfusion versus ex-situ normothermic machine perfusion in liver transplantation from donation after circulatory death. [PDF]

, 2022
BACKGROUND In-situ normothermic regional perfusion (NRP) and ex-situ normothermic machine perfusion (NMP) aim to improve outcomes of liver transplantation (LT) using controlled donation after circulatory death (cDCD).
Laing, Richard W., Nasralla, David, García-Valdecasas, Juan Carlos, Perera, M. Thamara P.R., Friend, Peter J., Mirza, Darius F, Bucur, Petru, Perera, M Thamara Pr, Paul, Andreas, Robin, Fabien, Sulpice, Laurent, Pittau, Gabriella, Laing, Richard W, Ploeg, Rutger, J, Laing, Richard, W, Rossignol, Guillaume, Mirza, Darius F., García‐Valdecasas, Juan Carlos, Mirza, Darius, F, Cauchy, François, Perera, M. Thamara P. R., Friend, Peter, J, Mohkam, Kayvan, Imber, Charles, Mabrut, Jean-Yves, Savier, Eric, Scatton, Olivier, Jassem, Wayel, Allard, Marc‐Antoine, Mergental, Hynek, Allard, Marc-Antoine, Mabrut, Jean‐Yves, Ploeg, Rutger J, Friend, Peter J, Dondero, Federica, Lesurtel, Mickaël, Muller, Xavier, Butler, Andrew, Salamé, Ephrem, Pradat, Pierre, Monbaliu, Diethard, Ploeg, Rutger J.   +41 more
core   +3 more sources