Results 1 to 10 of about 16,047 (285)

Patterns and Temporal Dynamics of Natural Recombination in Noroviruses [PDF]

Viruses, 2023
Noroviruses infect a wide range of mammals and are the major cause of gastroenteritis in humans. Recombination at the junction of ORF1 encoding nonstructural proteins and ORF2 encoding major capsid protein VP1 is a well-known feature of noroviruses ...
Yulia A. Vakulenko, Artem V. Orlov, Alexander N. Lukashev   +2 more
doaj   +3 more sources

Recombinant Noroviruses Circulating in Spain from 2016 to 2020 and Proposal of Two Novel Genotypes within Genogroup I

Microbiology Spectrum, 2022
Noroviruses are the leading cause of sporadic cases and outbreaks of viral gastroenteritis. For more than 20 years, most norovirus infections have been caused by the pandemic genotype GII.4, yet recent studies have reported the emergence of recombinant ...
Noemi Navarro-Lleó, Cristina Santiso-Bellón, Susana Vila-Vicent, Noelia Carmona-Vicente, Roberto Gozalbo-Rovira, Roberto Cárcamo-Calvo, Jesús Rodríguez-Díaz, Javier Buesa   +7 more
doaj   +2 more sources

Manipulation of immunodominant variable epitopes of norovirus capsid protein elicited cross-blocking antibodies to different GII.4 variants despite the low potency of the polyclonal sera [PDF]

Journal of Virology
Norovirus is a major cause of viral acute gastroenteritis. The predominant genotype, GII.4, presents a continuous emergence of new variants that could escape immunity developed in previous infections.
Kentaro Tohma, Lauren A. Ford-Siltz, Joseph A. Kendra, Gabriel I. Parra   +3 more
doaj   +2 more sources

Antigenic structural analysis of bat and human norovirus protruding (P) domains [PDF]

Journal of Virology
Dayna L. Holroyd, Akhil Kumar, Eduardo Vasquez, Veronika Masic, Mark von Itzstein, John B. Bruning, Grant S. Hansman   +6 more
doaj   +2 more sources

Human Norovirus Triggers Primary B Cell Immune Activation In Vitro

mBio, 2022
Human norovirus (HNoV) is a global health and socioeconomic burden, estimated to infect every individual at least five times during their lifetime. The underlying mechanism for the potential lack of long-term immune protection from HNoV infections is not
Carmen Mirabelli, Melissa K. Jones, Vivienne L. Young, Abimbola O. Kolawole, Irene Owusu, Mengrou Shan, Basel Abuaita, Holly Turula, Jose G. Trevino, Irina Grigorova, Steven K. Lundy, Costas A. Lyssiotis, Vernon K. Ward, Stephanie M. Karst, Christiane E. Wobus   +14 more
doaj   +1 more source

Detection of Porcine Norovirus GII.18 Strains in Pigs Using Broadly Reactive RT-qPCR Assay for Genogroup II Noroviruses. [PDF]

Food Environ Virol
Gupta AK, Heinonen M, König E, Mikkonen V, Maunula L.   +4 more
europepmc   +3 more sources

Lewis b antigen is a common ligand for genogroup I norovirus strains

FEBS Open Bio, 2022
Noroviruses are major causative agents of nonbacterial acute gastroenteritis in humans. Ten genogroups of noroviruses have been identified to date, among which genogroup I (GI) and genogroup II (GII) noroviruses are major pathogens for humans. GI and GII
Yuichi Someya
doaj   +1 more source

Understanding the relationship between norovirus diversity and immunity

Gut Microbes, 2021
Human noroviruses are the most common viral cause of acute gastroenteritis worldwide. Currently, there are no approved vaccines or specific therapeutics to treat the disease.
Lauren A. Ford-Siltz, Kentaro Tohma, Gabriel I. Parra   +2 more
doaj   +1 more source

Identification of compelling inhibitors of human norovirus 3CL protease to combat gastroenteritis: A structure-based virtual screening and molecular dynamics study

Frontiers in Chemistry, 2022
Human noroviruses (NV) are the most prevalent cause of sporadic and pandemic acute gastroenteritis. NV infections cause substantial morbidity and death globally, especially amongst the aged, immunocompromised individuals, and children.
Shan He, Shan He, Shan He, Alaa F. Nahhas, Alaa Hamed Habib, Mohammed Ali Alshehri, Saleh Alshamrani, Saeed A. Asiri, Mashael M. Alnamshan, Nawal Helmi, Nawal Helmi, Ibtesam Al-Dhuayan, Jawaher Almulhim, Ahmed M. Alharbi, Dongxiao Su, Ankita Kumari, Abdul Rahaman   +16 more
doaj   +1 more source

NOROVIRUSES - A HIDDEN THREAT

Problems of Infectious and Parasitic Diseases, 2022
Acute nonbacterial gastroenteritis is ubiquitous, and noroviruses are considered to be among the most common etiological agents. Noroviruses affect people of all ages.
Asya Stoyanova
doaj   +1 more source