Results 101 to 110 of about 94,967 (299)
Mild Focal Cooling Decouples Dendrites to Reconfigure Cortical Output
Advanced Science, EarlyView.Mild cooling of the cortical surface selectively modulates apical dendritic excitability, plasticity, and somato‐dendritic coupling, while uncoupling these effects from basal dendrites, and reshapes apical‐driven responses in barrel cortex during whisker touch.
Meisam Habibi Matin +2 more
wiley +1 more source
Nanomedicines as cancer therapeutics: Current status [PDF]
, 2013 As of 21st century, cancer is arguably the most complex and challenging disease known to mankind and an inevitable public health concern of this millennium.
Ahmad, F.J. +8 more
core +4 more sources
Advanced Science, EarlyView.An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu +11 more
wiley +1 more source
Role of magnetic nanoparticles in targeted drug delivery for central nervous system [PDF]
, 2016 Introduction: The treatment of neurological disease, such as brain cancer or neurodegenerative diseases, is one of the most difficult challenges in medicine.
Gharib, Alireza. +3 more
core
Advanced Science, EarlyView.We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong +8 more
wiley +1 more source
Cubosomes: evolving platform for intranasal drug delivery of neurotherapeutics
Future Journal of Pharmaceutical SciencesBackground As per World Health Organization (WHO) database, neurological and psychiatric disorders constitute a significant and escalating source of morbidity, impacting over one billion lives with a staggering 9 million fatalities.
Priyanka Gawarkar-Patil +3 more
doaj +1 more source
Insertos intranasales para dirigir moléculas activas al sistema nervioso central [PDF]
, 2019 Con motivo del auge actual acerca de los avances producidos en el tratamiento de las enfermedades neurodegenerativas, se están abarcando otras estrategias alternativas focalizadas hacia la consecución de una mayor efectividad de los tratamientos.
Martos Carrasco, Laura
core
Inhalable antitubercular therapy mediated by locust bean gum microparticles [PDF]
, 2016 Tuberculosis remains a major global health problem and alternative therapeutic approaches are needed. Considering the high prevalence of lung tuberculosis (80% of cases), the pulmonary delivery of antitubercular drugs in a carrier system capable of ...
Alves, Ana +5 more
core +2 more sources
Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES
Advanced Science, EarlyView.In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu +5 more
wiley +1 more source
Journal of Pharmacy & Pharmaceutical Sciences, 2013 PURPOSE: The aim of the study was to target clonazepam, a CNS active drug, to the brain through the non-invasive intranasal (in) route using of nanocarriers with proven safety METHOD: in clonazepam nanocarriers were prepared by mixing isopropyl ...
Hend Mohamed Abdel-Bar +3 more
doaj +1 more source