Results 71 to 80 of about 94,967 (299)

Perceived Impacts and Predictors of Cannabis Products used by Rheumatology Patients in Alberta: A Multivariable Analysis of Cross‐sectional Survey Data

Arthritis Care &Research, Accepted Article.
Objective This study aimed to characterize cannabis product choices (cannabinoid content and formulation) among rheumatology patients, and their associations with patient factors, patient reported perceived side effects and positive impacts. Methods An online survey (delivered from March to November 2022) was distributed by Alberta Health Services to ...
Susan Zhang, Samuel A.J. Lowe, Frank Sun, Allyson Jones, Tarek Turk, Joanne Olson, Pauline Paul, Shelby Yamamoto, Linda Kolewaski, Elaine Yacyshyn, Cheryl A. Sadowski   +10 more
wiley   +1 more source

Nose-to-Brain Translocation and Cerebral Biodegradation of Thin Graphene Oxide Nanosheets

Cell Reports Physical Science, 2020
Summary: Understanding the interactions of graphene oxide (GO)-based materials with biological systems is critical due to the potential applications of these materials.
Leon Newman, Artur Filipe Rodrigues, Dhifaf A. Jasim, Isabella Anna Vacchi, Cécilia Ménard-Moyon, Alberto Bianco, Cyrill Bussy, Kostas Kostarelos   +7 more
doaj   +1 more source

Olfactory ensheathing glia are required for embryonic olfactory axon targeting and the migration of gonadotropin-releasing hormone neurons. [PDF]

, 2013
Kallmann's syndrome is caused by the failure of olfactory axons and gonadotropin-releasing hormone (GnRH) neurons to enter the embryonic forebrain, resulting in anosmia and sterility.
Baker, Clare VH, Barraud, Perrine, St John, James A, Stolt, C Claus, Wegner, Michael   +4 more
core   +4 more sources

Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix

Advanced Functional Materials, EarlyView.
Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt, Jens Timmer, Elisabetta Ada Cavalcanti‐Adam   +2 more
wiley   +1 more source

Synthesis and Characterization of PCL-Idebenone Nanoparticles for Potential Nose-to-Brain Delivery

Biomedicines, 2023
The present work is focused on the preparation of an optimal model of poly-ε-caprolactone nanoparticles as potential carriers for nasal administration of idebenone. A solvent/evaporation technique was used for nanoparticle preparation.
Radka Boyuklieva, Asya Hristozova, Bissera Pilicheva   +2 more
doaj   +1 more source

Quantification of rutin in rats brain by UHPLC/ESI-Q-TOF-MS/MS after intranasal administration of rutin loaded chitosan nanoparticles [PDF]

, 2016
Rutin (RT), an antioxidant drug, has been utilized to treat cerebral ischemia hence a sensitive quantification method for estimation of RT in brain homogenate is necessary to develop. This study aims to prepare RT loaded Chitosan Nanoparticles (RT-CS-NPs)
Ahmad, Farhan Jalees, Ahmad, Niyaz, Ahmad, Rizwan, Alam, Md Aftab, Iqbal, Zeenat, Naqvi, Atta Abbas, Samim, Mohd   +6 more
core   +1 more source

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

A Single Chain Fragment Variant Binding Misfolded Alpha-Synuclein Exhibits Neuroprotective and Antigen-Specific Anti-Inflammatory Properties

Cells, 2022
Introduction. Alpha synuclein (αSyn) misfolding plays a requisite role in the pathogenesis of synucleinopathies. Direct toxicity to neurons, triggering neuroinflammation as well as the spreading and seeding of αSyn pathology are essential pathogenetic ...
Michael Fassler, Clara Benaim, Jacob George   +2 more
doaj   +1 more source

Formulation Strategies for Nose-to-Brain Drug Delivery

Journal of Pharmaceutical Technology, Research and Management, 2022
Background: Neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, Multiple Sclerosis, Dementia, and others are becoming more common globally due to people’s changing lifestyles. Furthermore, the presence of the Blood-Brain barrier and other limitations of oral and other routes of administration makes drug delivery to the brain ...
Manisha Vohra, Mohammad Amir, Amit Sharma, Sheetu Wadhwa   +3 more
openaire   +1 more source

Subject-variability effects on micron particle deposition in human nasal cavities [PDF]

, 2018
Validated computer simulations of the airflow and particle dynamics in human nasal cavities are important for local, segmental and total deposition predictions of both inhaled toxic and therapeutic particles.
Calmet, Hadrien, Houzeaux, Guillaume, Kleinstreuer, Clement, Kolanjiyil, Arun Varghese, Lehmkuhl Barba, Oriol, Olivares, Edgar, Vázquez, Mariano   +6 more
core   +2 more sources