Results 51 to 60 of about 94,967 (299)
Opportunities and challenges for the nasal administration of nanoemulsions [PDF]
, 2015 © 2015 Bentham Science Publishers. Nasal delivery has become a growing area of interest for drug administration as a consequence of several practical advantages, such as ease of administration and non-invasiveness.
Comfort, C +3 more
core +1 more source
Health Sciences Review, 2022 Central nervous system-related disorders are very difficult to manage with conventional therapeutics because of the selective and herculean nature of the blood-brain barrier which does not allow easy penetration of drug molecules into the brain.
Mayank Handa +4 more
doaj +1 more source
Efficacy of intranasal administration of artesunate in experimental cerebral malaria [PDF]
, 2014 BACKGROUND: Improving management of patients suffering from cerebral malaria is needed to reduce the devastating mortality and morbidity of the disease in endemic areas.
Adeline Lavoignat +7 more
core +2 more sources
PPARγ agonist-loaded PLGA -PEG nanocarriers as a potential treatment for Alzheimer’s disease: in vitro and in vivo studies [PDF]
, 2018 Objective: The first aim of this study was to develop a nanocarrier that could transport the peroxisome proliferator-activated receptor agonist, pioglitazone (PGZ) across brain endothelium and examine the mechanism of nanoparticle transcytosis.
Benito, Pol Andres +9 more
core +3 more sources
NOSE TO BRAIN DRUG DELIVERY SYSTEM
, 2022 Nose-to-Brain Drug Delivery System is an approach to deliver a drug directly in brain through the nose. Intranasal Drug delivery is very beneficial as it avoids first pass mechanism and can achieve greater concentration of drugs in Central Nervous System (CNS) at very low dose.
openaire +1 more source
Current Update on Transcellular Brain Drug Delivery
Pharmaceutics, 2022 It is well known that the presence of a blood–brain barrier (BBB) makes drug delivery to the brain more challenging. There are various mechanistic routes through which therapeutic molecules travel and deliver the drug across the BBB. Among all the routes,
Bhakti Pawar +6 more
doaj +1 more source
Intranasal Treatment of Central Nervous System Dysfunction in Humans [PDF]
, 2012 One of the most challenging problems facing modern medicine is how to deliver a given drug to a specific target at the exclusion of other regions. For example, a variety of compounds have beneficial effects within the central nervous system (CNS), but ...
Christian Benedict +6 more
core +1 more source
Formulation strategies for nose-to-brain drug delivery in Alzheimer's disease
Health Sciences Review, 2023 Alzheimer's disease (AD) is a neurodegenerative brain disorder that affects memory, thinking, concentration, and judgment, ultimately hindering a person's ability to perform routine daily activities.
Manisha Vohra +3 more
doaj +1 more source
Nose-to-Brain Targeting via Nanoemulsion: Significance and Evidence
Colloids and Interfaces, 2023 Background: Non-invasive and patient-friendly nose-to-brain pathway is the best-suited route for brain delivery of therapeutics as it bypasses the blood–brain barrier.
Shashi Kiran Misra, Kamla Pathak
doaj +1 more source
Inhalation of growth factors and apo-transferrin to protect and repair the hypoxic-ischemic brain [PDF]
, 2016 Hypoxic-ischemic brain damage is a major contributor to chronic neurological dysfunction and acute mortality in infants as well as in adults. In this review, we summarize recent publications demonstrating that the intranasal administration (INA) of apo ...
Guardia Clausi, Mariano +3 more
core +1 more source