Results 31 to 40 of about 94,967 (299)
Nose-To-Brain Delivery of PLGA-Diazepam Nanoparticles [PDF]
AAPS PharmSciTech, 2015 The objective of the present investigation was to optimize diazepam (Dzp)-loaded poly(lactic-co-glycolic acid) nanoparticles (NP) to achieve delivery in the brain through intranasal administration. Dzp nanoparticles (DNP) were formulated by nanoprecipitation and optimized using Box-Behnken design. The influence of various independent process variables (
Deepak, Sharma +6 more
openaire +2 more sources
Evaluation of Recent Intranasal Drug Delivery Systems to the Central Nervous System
Pharmaceutics, 2022 Neurological diseases continue to increase in prevalence worldwide. Combined with the lack of modifiable risk factors or strongly efficacious therapies, these disorders pose a significant and growing burden on healthcare systems and societies.
Tyler P. Crowe, Walter H. Hsu
doaj +1 more source
Nose-to-brain delivery of tacrine
Journal of Pharmacy and Pharmacology, 2007 Abstract In the treatment of Alzheimer's disease tacrine, a cholinesterase inhibitor, is not the drug of choice due to its low oral bioavailability, extensive hepatic first-pass effect, rapid clearance from the systemic circulation, pronounced hepatotoxicity, and the availability of drugs better than tacrine in the same pharmacological ...
Viral V, Jogani +4 more
openaire +2 more sources
Neem oil nanoemulsions: characterisation and antioxidant activity [PDF]
, 2017 The aim of the present work is to develop nanoemulsions (NEs), nanosized emulsions, manufactured for improving the delivery of active pharmaceutical ingredients. In particular, nanoemulsions composed of Neem seed oil, contain rich bioactive components,
Carafa, Maria +10 more
core +1 more source
Gels, 2023 The present study aimed to prepare, characterize, and evaluate a thermo-responsive sol–gel for intranasal delivery of lamotrigine (LTG), which was designed for sustained drug delivery to treat epilepsy.
Maria Riaz +8 more
doaj +1 more source
The nasal delivery of nanoencapsulated statins – An approach for brain delivery [PDF]
, 2016 © 2016 Clementino et al. Purpose: Along with their cholesterol-lowering effect, statins have shown a wide range of pleiotropic effects potentially beneficial to neurodegenerative diseases.
Barboza, T +11 more
core +2 more sources
Acta Pharmaceutica Sinica B, 2021 The management of the central nervous system (CNS) disorders is challenging, due to the need of drugs to cross the blood‒brain barrier (BBB) and reach the brain. Among the various strategies that have been studied to circumvent this challenge, the use of
Cláudia Pina Costa +3 more
doaj +1 more source
Decoration of nanovesicles with pH (low) insertion peptide (pHLIP) for targeted delivery [PDF]
, 2018 Acidity at surface of cancer cells is a hallmark of tumor microenvironments, which does not depend on tumor perfusion, thus it may serve as a general biomarker for targeting tumor cells.
Andreev O. A. +9 more
core +1 more source
Carbohydrate Polymer Technologies and Applications, 2023 Crossing the Blood Brain Barrier constitutes a challenge in drug administration to the brain. In this context, nose-to-brain delivery is explored as an alternative route in the treatment of central nervous system disorders, and nanotechnology constitutes
Giulia Nerli +6 more
doaj +1 more source
Non-invasive aerosol delivery and transport of gold nanoparticles to the brain [PDF]
, 2017 Targeted delivery of nanoscale carriers containing packaged payloads to the central nervous system has potential use in many diagnostic and therapeutic applications. Moreover, understanding of the bio-interactions of the engineered nanoparticles used for
Biswas, Pratim +4 more
core +2 more sources