Results 41 to 50 of about 94,967 (299)

Pharmacokinetics, absolute bioavailability and tolerability of ketamine after intranasal administration to dexmedetomidine sedated dogs [PDF]

, 2020
Intranasal ketamine has recently gained interest in human medicine, not only for its sedative, anaesthetic or analgesic properties, but also in the management of treatment resistant depression, where it has been shown to be an effective, fast acting ...
Croubels, Siska, Devreese, Mathias, Dockx, Robrecht, Duchateau, Luc, Peremans, Kathelijne, Polis, Ingeborgh, Vlerick, Lise   +6 more
core   +1 more source

Nose-to-Brain (N2B) Delivery: An Alternative Route for the Delivery of Biologics in the Management and Treatment of Central Nervous System Disorders

Pharmaceutics, 2023
In recent years, there have been a growing number of small and large molecules that could be used to treat diseases of the central nervous system (CNS). Nose-to-brain delivery can be a potential option for the direct transport of molecules from the nasal
Elizabeth J. Patharapankal, Adejumoke Lara Ajiboye, Claudia Mattern, Vivek Trivedi   +3 more
doaj   +1 more source

Catecholamine-Based Treatment in AD Patients: Expectations and Delusions. [PDF]

, 2015
In Alzheimer disease, the gap between excellence of diagnostics and efficacy of therapy is wide. Despite sophisticated imaging and biochemical markers, the efficacy of available therapeutic options is limited.
Alessandro eStefani, Alessandro eStefani, Atticus H Hainsworth, Claudio eLiguori, Enrica eOlivola, Giacoma eAngileri, Mariangela ePierantozzi, Salvatore eGalati, Valentina eSaviozzi, Vincenza eD’Angelo   +9 more
core   +3 more sources

Dual antibiotherapy of tuberculosis mediated by inhalable locust bean gum microparticles [PDF]

, 2017
Despite the existence of effective oral therapy, tuberculosis remains a deadly pathology, namely because of bacterial resistance and incompliance with treatments.
Alves, Ana D., Buttini, Francesca, Cavaco, Joana S., Grenha, Ana, Guerreiro, Filipa, Pontes, Jorge Filipe, Rodrigues, Susana, Rosa Da Costa, Ana   +7 more
core   +1 more source

Nose-to-brain delivery of self-assembled curcumin-lactoferrin nanoparticles: Characterization, neuroprotective effect and in vivo pharmacokinetic study

Frontiers in Bioengineering and Biotechnology, 2023
Curcumin (CUR) is a natural polyphenol extract with significant antioxidant and anti-inflammatory effects, which indicates its great potential for neuroprotection. Lactoferrin (LF), a commonly used oral carrier and targeting ligand, has not been reported
Linghui Li, Liwei Tan, Qian Zhang, Yushan Cheng, Yayuan Liu, Rui Li, Shuguang Hou   +6 more
doaj   +1 more source

Drug delivery in overcoming the blood-brain barrier: role of nasal mucosal grafting [PDF]

, 2017
The blood–brain barrier (BBB) plays a fundamental role in protecting and maintaining the homeostasis of the brain. For this reason, drug delivery to the brain is much more difficult than that to other compartments of the body. In order to bypass or cross
Carafa, Maria, Di Marzio, Luisa, Hanieh, PATRIZIA NADIA, Marianecci, Carlotta, Paolino, Donatella, Rinaldi, Federica   +5 more
core   +1 more source

Cachexia: Pathophysiology and Ghrelin Liposomes for Nose-to-Brain Delivery [PDF]

International Journal of Molecular Sciences, 2020
Cachexia, a severe multifactorial condition that is underestimated and unrecognized in patients, is characterized by continuous muscle mass loss that leads to progressive functional impairment, while nutritional support cannot completely reverse this clinical condition.
Cecilia T. de Barros, Alessandra C. Rios, Thaís F. R. Alves, Fernando Batain, Kessi M. M. Crescencio, Laura J. Lopes, Aleksandra Zielińska, Patricia Severino, Priscila G. Mazzola, Eliana B. Souto, Marco V. Chaud   +10 more
openaire   +3 more sources

Chitosan-g-oligo(epsilon-caprolactone) polymeric micelles: microwave-assisted synthesis and physicochemical and cytocompatibility characterization [PDF]

, 2015
With the aim to produce mucoadhesive polymeric micelles for drug administration by mucosal routes, chitosan-g-oligo(epsilon-caprolactone) copolymers were synthesized by the microwave-assisted ring-opening polymerization of epsilon-caprolactone using ...
Calderon, Marcelo, Glisoni, Romina Julieta, Moglioni, Albertina Gladys, Molina, María, Quintana Lazópulos, Silvina Soledad, Sosnik, Alejandro Dario   +5 more
core   +1 more source

Pharmacokinetics and Pharmacodynamics of Intranasal Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Nose-to-Brain Delivery

Pharmaceutics, 2022
Nose-to-brain drug delivery has been of great interest for the treatment of many central nervous system (CNS) diseases and psychiatric disorders over past decades.
Thi-Thao-Linh Nguyen, Han-Joo Maeng
doaj   +1 more source

Global Ethics and Nanotechnology: A Comparison of the Nanoethics Environments of the EU and China [PDF]

, 2012
The following article offers a brief overview of current nanotechnology policy, regulation and ethics in Europe and The People’s Republic of China with the intent of noting (dis)similarities in approach, before focusing on the involvement of the public ...
A Anderson, A Mnyusiwalla, AA Shvedova, AG Spagnolo, B McKibben, B Trouiller, C Buzea, D Bennett-Woods, D Evans, E Oberdorster, F Zhao, G Gaskell, G Kirsten, H Widdows, HB Friedman, J Schummer, J-H Hsaio, K Choi, K Finkler, K Pandza, L Jia, L Tang, M Oud, R Andorno, R Doubleday, RP Suttmeier, RW Berne, S Jasanoff, S Wood, Sally Dalton-Brown, SH Li, W Adams, W Hu   +32 more
core   +1 more source